- Management of hepatocellular carcinoma in China: Seeking common grounds while reserving differences
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Yang T, Wang MD, Xu XF, Li C, Wu H, Shen F
- KMID: 2541412
- Clin Mol Hepatol.
- 2023 Apr;29(2):342-344.
- doi: 10.3350/cmh.2023.0106
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- New targeted therapies for non-small cell lung cancer
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Lee EH, Kwak SH, Kim CY, Gwon HR, Kim EY, Chang YS
- KMID: 2541446
- J Korean Med Assoc.
- 2023 Mar;66(3):180-190.
- doi: 10.5124/jkma.2023.66.3.180
Background: Lung cancer is representative of a high frequency and high mortality disease and ranks at the top in incidence and mortality in Korea, when excluding thyroid cancer. In this... -
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- Management of the adverse effects of targeted therapy for cancer
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Ryu H
- KMID: 2539905
- J Korean Med Assoc.
- 2023 Feb;66(2):105-111.
- doi: 10.5124/jkma.2023.66.2.105
Background: Advances in genomics and molecular biology over the past 20 years have resulted in numerous approved molecular targeted cancer therapies. The two main approaches for targeted cancer therapy are... -
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- New Targeted Therapy for Non-Small Cell Lung Cancer
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Chung EK, Yong SH, Lee EH, Kim EY, Chang YS, Lee SH
- KMID: 2537198
- Tuberc Respir Dis.
- 2023 Jan;86(1):1-13.
- doi: 10.4046/trd.2022.0066
Lung cancer ranks first in cancer mortality in Korea and cancer incidence in Korean men. More than half of Korean lung cancer patients undergo chemotherapy, including adjuvant therapy. Cytotoxic agents,... -
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- Inhibition of MicroRNA-92a Improved Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats via Suppressing Oxidative Stress and Endothelial Dysfunction
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Tang Z, Song J, Yu Z, Cui K, Ruan Y, Liu Y, Wang T, Wang S, Liu J, Yang J
- KMID: 2537126
- World J Mens Health.
- 2023 Jan;41(1):142-154.
- doi: 10.5534/wjmh.210177
Purpose: To determine whether microRNA could be a therapy target of erectile dysfunction (ED) and the underlying mechanisms. Materials and Methods: Eight-week-old fasting male SD rats were intraperitoneally injected with streptozotocin... -
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- Molecular Pathology of Gastric Cancer
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Kim M, Seo AN
- KMID: 2535110
- J Gastric Cancer.
- 2022 Oct;22(4):273-305.
- doi: 10.5230/jgc.2022.22.e35
Gastric cancer (GC) is one of the most common lethal malignant neoplasms worldwide, with limited treatment options for both locally advanced and/or metastatic conditions, resulting in a dismal prognosis. Although... -
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- Biomarker-guided targeted therapy in platinum-resistant ovarian cancer (AMBITION; KGOG 3045): a multicentre, open-label, five-arm, uncontrolled, umbrella trial
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Lee JY, Kim BG, Kim JW, Lee JB, Park E, Joung JG, Kim S, Choi CH, Kim HS, on behalf of Korean Gynecologic Oncology Group (KGOG) investigators
- KMID: 2537892
- J Gynecol Oncol.
- 2022 Jul;33(4):e45.
- doi: 10.3802/jgo.2022.33.e45
Objective Management of heavily pre-treated platinum-resistant ovarian cancer remains a therapeutic challenge. Outcomes are poor with non-platinum, single-agent chemotherapy (CT); however, molecularly targeted anticancer therapies provide new options. Methods This open-label, investigator-initiated, phase... -
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- Major clinical research advances in gynecologic cancer in 2021
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Park JY, Lee JY, Lee YY, Shim SH, Suh DH, Kim JW
- KMID: 2536891
- J Gynecol Oncol.
- 2022 Mar;33(2):e43.
- doi: 10.3802/jgo.2022.33.e43
In the 2021 series, we not only summarized the major clinical research advances in gynecologic oncology but also added discussions to every part, based on communications at the conference. A... -
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- Targeted Immunotherapy for Autoimmune Disease
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Jung SM, Kim WU
- KMID: 2536240
- Immune Netw.
- 2022 Feb;22(1):e9.
- doi: 10.4110/in.2022.22.e9
In the past few decades, biological drugs and small molecule inhibitors targeting inflammatory cytokines, immune cells, and intracellular kinases have become the standard-of-care to treat autoimmune diseases. Inhibition of TNF,... -
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- Risks and management of hypertension in cancer patients undergoing targeted therapy: a review
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Zhu X, Wu S
- KMID: 2529745
- Clin Hypertens.
- 2022;28(1):14.
- doi: 10.1186/s40885-022-00197-3
Background: Rapid progress over the last decade has added numerous agents targeting specific cellular signaling pathways to the treatment armamentarium for advanced cancer. However, many of these agents can cause... -
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- Cancer of Unknown Primary: Diagnosis and Treatment
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Kim YS, Lee SI
- KMID: 2522014
- Korean J Med.
- 2021 Oct;96(5):408-414.
- doi: 10.3904/kjm.2021.96.5.408
Cancer of unknown primary (CUP) is a heterogenous group of cancers for which the anatomical site of origin is unidentifiable on the basis of standard evaluation and imaging. CUPs account... -
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- Major clinical research advances in gynecologic cancer in 2020
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Lee YY, Choi MC, Park JY, Suh DH, Kim JW
- KMID: 2526123
- J Gynecol Oncol.
- 2021 Jul;32(4):e53.
- doi: 10.3802/jgo.2021.32.e53
In 2020 series, we summarized the major clinical research advances in gynecologic oncology with providing representative figures of the most influential study for 1 of each 3 gynecologic cancers: cervix,... -
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- An Updated Review of Chronic Lymphocytic Leukemia
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Cho HJ, Sohn SK
- KMID: 2516471
- Korean J Med.
- 2021 Jun;96(3):195-208.
- doi: 10.3904/kjm.2021.96.3.195
Chronic lymphocytic leukemia (CLL), characterized by monoclonal B-cell accumulation and highly variable clinical manifestations that range from an indolent to an aggressive course, is rare in Korea. Asymptomatic patients with... -
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- Pulmonary toxicities of molecular targeted antineoplastic agents: a single-center 10-year experience
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Lee MY, Yoon SY, Kim KH, Lee N, Kim HY, Hwang JH, Won JH
- KMID: 2515699
- Korean J Intern Med.
- 2021 May;36(3):689-698.
- doi: 10.3904/kjim.2020.295
Background/Aims: A better understanding of cancer cell biology has led to the discovery and development of several new targeted agents for cancer. These drugs are widely used in cancer treatment... -
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- Optimizing the management of intermediate-stage hepatocellular carcinoma: Current trends and prospects
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Torimura T, Iwamoto H
- KMID: 2514763
- Clin Mol Hepatol.
- 2021 Apr;27(2):236-245.
- doi: 10.3350/cmh.2020.0204
Hepatocellular carcinoma (HCC) is usually accompanied by chronic liver damage, which sometimes influences the selection of HCC treatment. The Barcelona Clinic Liver Cancer (BCLC) staging system, which was first introduced... -
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- Structure of SARS-CoV-2 Spike Glycoprotein for Therapeutic and Preventive Target
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Hong J, Jhun H, Choi YO, Taitt AS, Bae S, Lee Y, Song Cs, Yeom SC, Kim S
- KMID: 2513574
- Immune Netw.
- 2021 Feb;21(1):e8.
- doi: 10.4110/in.2021.21.e8
The global crisis caused by the coronavirus disease 2019 (COVID-19) led to the most significant economic loss and human deaths after World War II. The pathogen causing this disease is... -
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- New Molecular Targeted Therapy of Metastatic Colorectal Cancer
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Jo J
- KMID: 2512406
- Ewha Med J.
- 2021 Jan;44(1):11-18.
- doi: 10.12771/emj.2021.44.1.11
Over the past decade, substantial advances have been made in the individualization of therapeutic strategies for metastatic colorectal cancer (mCRC). Treatment strategies have been developed and classified according to their... -
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- TM4SF4 and LRRK2 Are Potential Therapeutic Targets in Lung and Breast Cancers through Outlier Analysis
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Jung K, Choi JS, Koo BM, Kim YJ, Song JY, Sung M, Chang ES, Noh KW, An S, Lee MS, Song K, Lee H, Kim RN, Shin YK, Oh DY, Choi YL
- KMID: 2510643
- Cancer Res Treat.
- 2021 Jan;53(1):9-24.
- doi: 10.4143/crt.2020.434
Purpose To find biomarkers for disease, there have been constant attempts to investigate the genes that differ from those in the disease groups. However, the values that lie outside the overall... -
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- Roles of the complement system in alcohol-induced liver disease
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Zhou Y, Yuan G, Zhong F, He S
- KMID: 2507989
- Clin Mol Hepatol.
- 2020 Oct;26(4):677-685.
- doi: 10.3350/cmh.2020.0094
Alcohol-induced liver disease (ALD) is a complex disorder, with a disease spectrum ranging from steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Although the pathogenesis of ALD is incompletely understood and... -
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- Targeted Therapy for Non-Small Cell Lung Cancer
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Kim JS, Kang EJ
- KMID: 2501900
- Korean J Med.
- 2020 Apr;95(2):78-88.
- doi: 10.3904/kjm.2020.95.2.78
Treatment of progressive non-small cell lung cancer (NSCLC) has advanced remarkably, due in part to the development of targeted therapies. Several gene alterations, including EGFR, ALK, ROS1, and BRAF, play... -
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