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Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases

Oshima T, Miwa H

  • KMID: 2517542
  • J Neurogastroenterol Motil.
  • 2021 Jul;27(3):443.
  • doi: 10.5056/jnm18029A
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When Will My Esophagus Be Fixed?

Li ZL, Miwa H

  • KMID: 2325784
  • J Neurogastroenterol Motil.
  • 2013 Apr;19(2):124-125.
No abstract available.
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Is a Patient With Asymptomatic Esophagitis Really Hyposensitive to Acid and Distention?

Yamasaki T, Watari J, Oshima T, Tomita T, Miwa H

  • KMID: 2325824
  • J Neurogastroenterol Motil.
  • 2011 Jul;17(3):318-319.
No abstract available.
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Do Histamine-2 Receptor Antagonists and Proton Pump Inhibitors Really Have No Effect on the Gastric Emptying Rate?

Tomita T, Miwa H

  • KMID: 2325851
  • J Neurogastroenterol Motil.
  • 2011 Oct;17(4):434-434.
No abstract available.
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Preventing Metachronous Gastric Cancer after the Endoscopic Resection of Gastric Epithelial Neoplasia: Roles of Helicobacter pylori Eradication and Aspirin

Watari J, Tomita T, Tozawa K, Oshima T, Fukui H, Miwa H

Whether Helicobacter pylori eradication actually reduces the risk of metachronous gastric cancer (MGC) development remains a controversial question. In this review, we addressed this topic by reviewing the results of...
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Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders

Fukui H, Xu X, Miwa H

  • KMID: 2417381
  • J Neurogastroenterol Motil.
  • 2018 Jul;24(3):367-386.
  • doi: 10.5056/jnm18071
Gut microbiota exert a pivotal influence on various functions including gastrointestinal (GI) motility, metabolism, nutrition, immunity, and the neuroendocrine system in the host. These effects are mediated by not only...
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Laparoscopic Resection of a Jejunal Inflammatory Fibroid Polyp that Caused Occult Gastrointestinal Bleeding, Diagnosed via Capsule Endoscopy and Double-Balloon Enteroscopy: A Case Report

Kameda C, Miwa H, Kawabata R, Marukawa D, Murakami M, Noura S, Shimizu J, Hasegawa J

An inflammatory fibroid polyp (IFP) is a mesenchymal tumor of the gastrointestinal tract. IFPs in the small intestine are the most frequently detected with symptoms, such as abdominal pain and...
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Esophageal Sensation and Esophageal Hypersensitivity: Overview From Bench to Bedside

Miwa H, Kondo T, Oshima T, Fukui H, Tomita T, Watari J

  • KMID: 2204231
  • J Neurogastroenterol Motil.
  • 2010 Oct;16(4):353-362.
Noxious stimuli in the esophagus activate nociceptive receptors on esophageal mucosa, such as transient receptor potential, acid-sensing ion channel and the P2X family, a family of ligand-gated ion channels responsive...
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Analysis of the Gastrointestinal Symptoms of Uninvestigated Dyspepsia and Irritable Bowel Syndrome

Hori K, Matsumoto , Miwa H

  • KMID: 2284062
  • Gut Liver.
  • 2009 Sep;3(3):192-196.
BACKGROUND/AIMS: Epidemiological studies suggest that there is a considerable overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS). The aim of this study was to examine concurrent gastrointestinal symptoms...
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Epidemiology of Functional Gastrointestinal Disorders in Japan and in the World

Oshima T, Miwa H

  • KMID: 2433471
  • J Neurogastroenterol Motil.
  • 2015 Jul;21(3):320-329.
  • doi: 10.5056/jnm14165
Functional gastrointestinal disorders (FGIDs), represented by functional dyspepsia (FD) and irritable bowel syndrome (IBS), are a group of disorders that include variable combinations of chronic or recurrent gastrointestinal symptoms not...
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Prevalence and Self-recognition of Chronic Constipation: Results of an Internet Survey

Tamura A, Tomita T, Oshima T, Toyoshima , Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Ikehara H, Ohda Y, Fukui H, Watari J, Miwa H

  • KMID: 2433461
  • J Neurogastroenterol Motil.
  • 2016 Oct;22(4):677-685.
  • doi: 10.5056/jnm15187
BACKGROUND/AIMS: Although chronic constipation is a common symptom, to date no international consensus has been reached regarding its definition. The aims of this study were (1) to investigate defecation habits...
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Yokukansan Suppresses Gastric Hypersensitivity and Eosinophil-associated Microinflammation in Rats With Functional Dyspepsia

Duan S, Imamura N, Kondo T, Kanda H, Kogure Y, Okugawa T, Fukushima M, Tomita T, Oshima T, Fukui H, Noguchi K, Dai Y, Miwa H

  • KMID: 2528040
  • J Neurogastroenterol Motil.
  • 2022 Apr;28(2):255-264.
  • doi: 10.5056/jnm21204
Background/Aims Herbal medicine is an important complementary therapy for functional dyspepsia (FD). However, its effect against gastric hypersensitivity in patients with FD has rarely been evaluated. Yokukansan (YKS), a traditional Japanese...
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Esophagography in Patients With Esophageal Achalasia Diagnosed With High-resolution Esophageal Manometry

Yamasaki T, Tomita T, Mori S, Takimoto M, Tamura A, Hara K, Kondo T, Kono T, Tozawa K, Ohda Y, Oshima T, Fukui H, Watari J, Miwa H

  • KMID: 2417384
  • J Neurogastroenterol Motil.
  • 2018 Jul;24(3):403-409.
  • doi: 10.5056/jnm17147
BACKGROUND/AIMS: High-resolution esophageal manometry (HREM) is considered to be the gold standard for the diagnosis of achalasia. However, the Japan Esophageal Society recommends that esophagography is also accurate in either...
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Prevalence of Gastric Motility Disorders in Patients with Functional Dyspepsia

Asano H, Tomita T, Nakamura K, Yamasaki T, Okugawa T, Kondo T, Kono T, Tozawa K, Ohda Y, Oshima T, Fukui H, Fukushima , Hirota S, Watari J, Miwa H

  • KMID: 2387830
  • J Neurogastroenterol Motil.
  • 2017 Jul;23(3):392-399.
  • doi: 10.5056/jnm16173
BACKGROUND/AIMS: Gastric motility abnormalities have been considered to be pathophysiological features of functional dyspepsia (FD) that are closely related to dyspepsia symptoms, especially postprandial distress syndrome (PDS). The aims of...
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Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases

Oshima T, Miwa H

  • KMID: 2417378
  • J Neurogastroenterol Motil.
  • 2018 Jul;24(3):334-344.
  • doi: 10.5056/jnm18029
Conventional proton pump inhibitors (PPIs) are used as a first-line therapy to treat acid-related diseases worldwide. However, they have a number of limitations including slow onset of action, influence by...
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Diarrhea-predominant Irritable Bowel Syndrome-like Symptoms in Patients With Quiescent Crohn’s Disease: Comprehensive Analysis of Clinical Features and Intestinal Environment Including the Gut Microbiome, Organic Acids, and Intestinal Permeability

Tomita T, Fukui H, Morishita D, Maeda A, Makizaki Y, Tanaka Y, Ohno H, Oshima T, Miwa H

  • KMID: 2537945
  • J Neurogastroenterol Motil.
  • 2023 Jan;29(1):102-112.
  • doi: 10.5056/jnm22027
Background/Aims Diarrhea-predominant irritable bowel syndrome (IBS-D)-like symptoms frequently occur in patients with quiescent Crohn’s disease (CD). To investigate the factors underlying IBS-D-like symptoms in patients with quiescent CD, we performed a...
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Cytapheresis in Patients with Severe Ulcerative Colitis after Failure of Intravenous Corticosteroid: A Long-Term Retrospective Cohort Study

Fukunaga K, Nagase K, Kusaka T, Hida N, Ohda Y, Yoshida K, Tozawa K, Kamikozuru K, Iimuro M, Nakamura S, Miwa H, Matsumoto

  • KMID: 1744239
  • Gut Liver.
  • 2009 Mar;3(1):41-47.
BACKGROUND/AIMS: Cytapheresis (CAP) is a novel strategy for ulcerative colitis (UC). However, there is insufficient data on the long-term outcome of UC patients who achieve remission by CAP. This study...
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Adsorptive Granulocyte/Monocyte Apheresis for the Maintenance of Remission in Patients with Ulcerative Colitis: A Prospective Randomized, Double Blind, Sham-Controlled Clinical Trial

Fukunaga K, Yokoyama Y, Kamokozuru K, Nagase K, Nakamura S, Miwa H, Matsumoto

  • KMID: 2167411
  • Gut Liver.
  • 2012 Oct;6(4):427-433.
BACKGROUND/AIMS: Weekly granulocyte/monocyte adsorption (GMA) to deplete elevated and activated leucocytes should serve as a non-pharmacological intervention to induce remission in patients with ulcerative colitis (UC). This trial assessed the...
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Intravenous Corticotropin-releasing Hormone Administration Increases Esophageal Electrical Sensitivity in Healthy Individuals

Yamasaki T, Tomita T, Takimoto M, Kondo T, Tozawa K, Ohda Y, Oshima T, Fukui H, Watari J, Miwa H

  • KMID: 2395420
  • J Neurogastroenterol Motil.
  • 2017 Oct;23(4):526-532.
  • doi: 10.5056/jnm17067
BACKGROUND/AIMS: When a person is experiencing stress, corticotropin-releasing hormone (CRH) can modulate gut physiologies, such as visceral sensation or gastrointestinal motility, and its intravenous administration mimics stress-induced physiological changes. However,...
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A Randomized Double-blind Placebo-controlled Trial on the Effect of Magnesium Oxide in Patients With Chronic Constipation

Mori S, Tomita T, Fujimura K, Asano H, Ogawa T, Yamasaki T, Kondo T, Kono T, Tozawa K, Oshima T, Fukui H, Kimura T, Watari J, Miwa H

  • KMID: 2460486
  • J Neurogastroenterol Motil.
  • 2019 Oct;25(4):563-575.
  • doi: 10.5056/jnm18194
BACKGROUND/AIMS: Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic...
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