- The Influence of Bcl-3 Expression on Cell Migration and Chemosensitivity of Gastric Cancer Cells via Regulating Hypoxia-Induced Protective Autophagy
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Hu L, Bai Z, Ma X, Bai N, Zhang Z
- KMID: 2471929
- J Gastric Cancer.
- 2020 Mar;20(1):95-105.
- doi: 10.5230/jgc.2020.20.e9
PURPOSE: Gastric cancer is a highly metastatic malignant tumor, often characterized by chemoresistance and high mortality. In the present study, we aimed to investigate the role of B-cell lymphoma 3... -
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- Upregulated Long Noncoding RNA LINC01234 Predicts Unfavorable Prognosis for Colorectal Cancer and Negatively Correlates With KLF6 Expression
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Jiang X, Zhu Q, Wu P, Zhou F, Chen J
- KMID: 2460913
- Ann Lab Med.
- 2020 Mar;40(2):155-163.
- doi: 10.3343/alm.2020.40.2.155
BACKGROUND: LINC01234, a long noncoding RNA (lncRNA), is overexpressed in several cancers, including colorectal cancer (CRC). We investigated the role of LINC01234 in CRC development and confirmed its correlation with... -
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- Antitumor effect of TW-37, a BH3 mimetic in human oral cancer
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Ahn CH, Lee WW, Jung YC, Shin JA, Hong KO, Choi S, Swarup N, Kim J, Ahn MH, Jung M, Cho SD, Jin B
- KMID: 2470017
- Lab Anim Res.
- 2019 Dec;35(4):194-201.
- doi: 10.1186/s42826-019-0028-7
TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not... -
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- LINC00703 Acts as a Tumor Suppressor via Regulating miR-181a/KLF6 Axis in Gastric Cancer
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Yang H, Peng M, Li Y, Zhu R, Li X, Qian Z
- KMID: 2466034
- J Gastric Cancer.
- 2019 Dec;19(4):460-472.
- doi: 10.5230/jgc.2019.19.e43
PURPOSE: Long noncoding RNA 00703 (LINC00703) was found originating from a region downstream of Kruppel-like factor 6 (KLF6) gene, having 2 binding sites for miR-181a. Since KLF6 has been reported... -
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- The Use of Foxa2-Overexpressing Adipose Tissue-Derived Stem Cells in a Scaffold System Attenuates Acute Liver Injury
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Chae YJ, Jun DW, Lee JS, Saeed WK, Kang HT, Jang K, Lee JH
- KMID: 2458529
- Gut Liver.
- 2019 Jul;13(4):450-460.
- doi: 10.5009/gnl18235
BACKGROUND/AIMS: For the clinical application of stem cell therapy, functional enhancement is needed to increase the survival rate and the engraftment rate. The purpose of this study was to investigate... -
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- KIF11 Functions as an Oncogene and Is Associated with Poor Outcomes from Breast Cancer
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Zhou J, Chen WR, Yang LC, Wang J, Sun JY, Zhang WW, He ZY, Wu SG
- KMID: 2454312
- Cancer Res Treat.
- 2019 Jul;51(3):1207-1221.
- doi: 10.4143/crt.2018.460
PURPOSE: The study aimed to search and identify genes that were differentially expressed in breast cancer, and their roles in cancer growth and progression. MATERIALS AND METHODS: The Gene Expression Omnibus... -
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- Development of a Novel Imaging Agent for Determining Albumin Uptake in Solid Tumors
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Daum S, Magnusson , Pes L, Garcia Fernandez J, Chercheja , Medda F, Nollmann F, Koester SD, Perez Galan P, Warnecke A, Abu Ajaj K, Kratz F
- KMID: 2450009
- Nucl Med Mol Imaging.
- 2019 Jun;53(3):189-198.
- doi: 10.1007/s13139-019-00587-w
PURPOSE: The purpose of this study was to investigate the albumin-binding compound 111In-C4-DTPA as an imaging agent for the detection of endogenous albumin accumulation in tumors. METHODS: 111In-C4-DTPA was injected in... -
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- Preclinical Efficacy of [Vâ´Qâµ]dDAVP, a Second Generation Vasopressin Analog, on Metastatic Spread and Tumor-Associated Angiogenesis in Colorectal Cancer
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Garona J, Sobol NT, Pifano M, Segatori V, Gomez DE, Ripoll GV, Alonso DF
- KMID: 2464391
- Cancer Res Treat.
- 2019 Apr;51(2):438-450.
- doi: 10.4143/crt.2018.040
PURPOSE: Control of metastatic spread of colorectal cancer (CRC) remains as a major therapeutic challenge. [V4 Q5 ]dDAVP is a vasopressin peptide analog with previously reported anticancer activity against carcinoma... -
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- Effects of cisplatin on photosensitizer-mediated photodynamic therapy in breast tumor-bearing nude mice
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Ahn TG, Jung JM, Lee EJ, Choi JH
- KMID: 2471683
- Obstet Gynecol Sci.
- 2019 Mar;62(2):112-119.
- doi: 10.5468/ogs.2019.62.2.112
OBJECTIVE: This study aimed to evaluate the potential effects of cisplatin on photodynamic therapy (PDT) in breast cancer using a breast tumor-bearing mouse model. METHODS: In this study, breast tumor (experimental... -
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- Olaparib induced senescence under P16 or P53 dependent manner in ovarian cancer
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Wang Z, Gao J, Zhou J, Liu H, Xu C
- KMID: 2457138
- J Gynecol Oncol.
- 2019 Mar;30(2):e26.
- doi: 10.3802/jgo.2019.30.e26
OBJECTIVE: Poly (ADP-ribose) polymerase (PARP) is an important molecule in the early stress response of DNA damage, which is involved in DNA damage repair and cellular senescence. Olaparib, as PARP... -
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- Adipose-Derived Stem Cell Coculturing Stimulates Integrin-Mediated Extracellular Matrix Adhesion of Melanocytes by Upregulating Growth Factors
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Kim H, Yi N, Do BR, Lee AY
- KMID: 2442010
- Biomol Ther.
- 2019 Feb;27(2):185-192.
- doi: 10.4062/biomolther.2018.203
Coculture with adipose-derived stem cells (ADSCs) can stimulate proliferation and migration of melanocytes. To enhance outcomes of skin disorders caused by melanocyte loss or death, mixed transplantation with ADSCs has... -
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- Effect of bFGF and fibroblasts combined with hyaluronic acid-based hydrogels on soft tissue augmentation: an experimental study in rats
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Lee SY, Park Y, Hwang SJ
- KMID: 2468994
- Maxillofac Plast Reconstr Surg.
- 2019 ;41(1):47.
- doi: 10.1186/s40902-019-0234-0
BACKGROUND: Hyaluronic acid (HA) has been applied as a primary biomaterial for temporary soft tissue augmentation and as a carrier for cells and the delivery of growth factors to promote... -
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- [¹â¸F]FET PET is a useful tool for treatment evaluation and prognosis prediction of anti-angiogenic drug in an orthotopic glioblastoma mouse model
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Kim OS, Park JW, Lee ES, Yoo RJ, Kim WI, Lee KC, Shim JH, Chung HK
- KMID: 2459302
- Lab Anim Res.
- 2018 Dec;34(4):248-256.
- doi: 10.5625/lar.2018.34.4.248
O-2-¹â¸F-fluoroethyl-l-tyrosine ([¹â¸F]FET) has been widely used for glioblastomas (GBM) in clinical practice, although evaluation of its applicability in non-clinical research is still lacking. The objective of this study was to... -
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- Tumorsphere formation and cancer stem cell characterization of REM134 canine mammary carcinoma cells
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Byeon JS, Lee J, Jeong DU, Gu NY, Cho IS, Cha SH
- KMID: 2437695
- Korean J Vet Res.
- 2018 Dec;58(4):201-209.
- doi: 10.14405/kjvr.2018.58.4.201
Canine mammary tumors are among the most frequently observed cutaneous tumors in female dogs. Cancer stem cells (CSCs), referred to as tumor-initiating cells, are thought to have properties similar to... -
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- RPS15a Silencing Suppresses Cell Proliferation and Migration of Gastric Cancer
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Shi D, Liu J
- KMID: 2426330
- Yonsei Med J.
- 2018 Dec;59(10):1166-1173.
- doi: 10.3349/ymj.2018.59.10.1166
PURPOSE: Information on the possible role of the ribosomal protein S15a (RPS15a) in gastric cancer is scarce. The aim of this study was to evaluate the impact of RPS15a gene... -
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- Local Subcutaneous Injection of Erythropoietin Might Improve Fat Graft Survival, Whereas Continuous Infusion Using an Osmotic Pump Device Was Harmful by Provoking an Overwhelming Foreign Body Reaction in a Nude Mouse Model
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Kim EK, Lee Y, Lee HJ, Hong JP
- KMID: 2437074
- Arch Aesthetic Plast Surg.
- 2018 Oct;24(3):128-133.
- doi: 10.14730/aaps.2018.24.3.128
BACKGROUND: Since the survival of grafted fat requires successful revascularization, we hypothesized that local delivery of erythropoietin (EPO), a hemangiogenic and antiapoptotic factor, might enhance the survival of fat grafts... -
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- Preclinical Study of Novel Curcumin Analogue SSC-5 Using Orthotopic Tumor Xenograft Model for Esophageal Squamous Cell Carcinoma
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Tung LN, Song S, Chan KT, Choi MY, Lam HY, Chan CM, Chen Z, Wang HK, Leung HT, Law S, Huang Y, Song H, Lee NP
- KMID: 2424808
- Cancer Res Treat.
- 2018 Oct;50(4):1362-1377.
- doi: 10.4143/crt.2017.353
PURPOSE: Tumor xenograft model is an indispensable animal cancer model. In esophageal squamous cell carcinoma (ESCC) research, orthotopic tumor xenograft model establishes tumor xenograft in the animal esophagus, which allows... -
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- Effect of Poly(Lactide-Co-Glycolide) Nanoparticles on Local Retention of Fluorescent Material: An Experimental Study in Mice
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Kang Y, Lee E, Lee JW, Kim SR, Kang MJ, Choi YW, Ahn JM, Kang Y, Kang HS
- KMID: 2418559
- Korean J Radiol.
- 2018 Oct;19(5):950-956.
- doi: 10.3348/kjr.2018.19.5.950
OBJECTIVE: Poly(lactide-co-glycolide) (PLGA) nanoparticles are promising materials for the development of new drug-releasing systems. The purpose of this study was to evaluate the in vivo retention time of materials loaded... -
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- Hsa-miRNA-143-3p Reverses Multidrug Resistance of Triple-Negative Breast Cancer by Inhibiting the Expression of Its Target Protein Cytokine-Induced Apoptosis Inhibitor 1 In Vivo
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Deng YW, Hao WJ, Li YW, Li YX, Zhao BC, Lu D
- KMID: 2421365
- J Breast Cancer.
- 2018 Sep;21(3):251-258.
- doi: 10.4048/jbc.2018.21.e40
PURPOSE: Multidrug resistance (MDR) remains a major obstacle in the treatment of triple-negative breast cancer (TNBC) with conventional chemotherapeutic agents. A previous study demonstrated that hsa-miRNA-143-3p plays a vital role... -
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- In Vitro and In Vivo Osteogenesis of Human Orbicularis Oculi Muscle-Derived Stem Cells
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Liu G, Liao C, Chen X, Wu Y
- KMID: 2418101
- Tissue Eng Regen Med.
- 2018 Aug;15(4):445-452.
- doi: 10.1007/s13770-018-0122-1
BACKGROUND: Cell-based therapies for treating bone defects require a source of stem cells with osteogenic potential. There is evidence from pathologic ossification within muscles that human skeletal muscles contain osteogenic... -
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