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Minimal Phototoxic Dose for Vitiliginous Skin Lesions

Kim H, Park JK, Seo YJ, Lee JH

  • KMID: 2302852
  • Korean J Dermatol.
  • 2004 Aug;42(8):983-987.
BACKGROUND: Photochemotherapy (PUVA) is the effective treatment for vitiligo. It is necessary to measure the minimal phototoxic dose (MPD) in order to ascertain a safe, effective UVA dose needed for...
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Therapeutic Effects of PUVA Therapy with Percentage Increments for Psoriasis, Evaluated by the Changes of Mpd Values

Lee CW, Kim YH, Lee BG, Song KH, Kim KH

  • KMID: 2303088
  • Korean J Dermatol.
  • 2002 Sep;40(9):1083-1088.
BACKGROUND: The PUVA therapy of psoriasis is a very effective therapeutic modality that combines the action of light and drugs. Generally the conventional PUVA therapy based on patient's skin type...
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Effect of PUVA on Nerve Growth Factor Expression in Cultured Keratinocytes

Lee MH, Kim HJ, Lee JW, Kim YI

  • KMID: 2285263
  • Korean J Physiol Pharmacol.
  • 2002 Oct;6(5):275-279.
Nerve growth factor (NGF) is an important autocrine growth factor and also a survival factor for keratinocytes. NGF may act in the hyperproliferative condition, psoriasis. Clinically, the combination of psoralen...
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Bath-8-MOP-UVA Therapy for Psoriasis

Jeong CW, Park SH, Kim MM, Bok HS, Yeo UC, Lee ES

  • KMID: 1568201
  • Korean J Dermatol.
  • 2000 Jun;38(6):756-761.
BACKGROUND: An alternative approach to oral PUVA therapy for psoriasis, psoralen bath plus UVA therapy(bath PUVA therapy) that avoids the adverse effects associated with oral PUVA therapy has increasingly been...
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Comparison of Local Bath-PUVA with Steroid Treatment in Palmoplantar Pustular Psoriasis and Dyshidrotic Eczema

Kim J, Choi YW, Choi HY, Myung KB

  • KMID: 1568197
  • Korean J Dermatol.
  • 2000 Jun;38(6):742-749.
BACKGROUND: Local bath-PUVA(LB-PUVA) therapy has been recently tried for the treatment of palmoplantar pustular psoriasis and chronic eczema with successful results. However it has not been reported that the effectiveness...
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Study on the Development of a Rapid Detection Method for Pathogenic Yersinia enterocolitica and Yersinia pseudotuberculosis by Nested Polymerase Chain Reaction

Oh HJ, Min HK, Sohn YW, Hong SH

  • KMID: 1943432
  • J Korean Soc Microbiol.
  • 1999 Apr;34(2):175-187.
A nested polymerase chain reaction (PCR) was applied to detect and identify pathogenic Yersinia enterocolitica and Y. pseudotuberculosis. We used photochemical postamplification procedure with 8-methoxypsoralen to control carryover contamination. Using...
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Comparison of the Concentrations of 8-MOP in both Plasma and Suction Blister Fluid after Oral Ingestion

Yeo UC, Kim SH, Kim MM, Jung WH, Choi KE, Jung SY, Min HG

BACKGROUND: The value of plasma concentration of 8-Methoxypsoralen(8-MOP) in the supervision of photochemotherapy has been recognized. However, plasma levels of 8-MOP were not proportionate to the degree of PUVA induced...
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Photoallergic Dermatitis due to 8-Methoxypsoralen

Choi HJ, Hann SK, Park YK, Chin SH

One adverse effect of PUVA therapy is the development of severe dermatitis. Only a few cases of photoallergy to psoralens during PUVA therapy have been reported. We describe herein a...
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Minimal Phototoxic Dose for a Vitiliginous Skin Lesion

Park JK, Kim YS, Rho YW, Yoon SY, Kim TW, Lee WJ, Suhr KB, Lee JH

  • KMID: 2230567
  • Korean J Dermatol.
  • 1998 Apr;36(2):241-245.
BACKGROUND: It is mandatory to measure the minimal phototoxic dose(MPD) in order to determine adequate irradiation of UV-A in photochemotherapy. However, the measurement of MPD is not easy in some...
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Study of the Minimal Erythema Dose and Minimal Melanogenic Dose of UVA - 1 and Minimal Phototoxic Dose of UVA - 1 and UVA - 2 in Young Adult Koreans

Kim YK, Chae YS, Suh KS, Kim ST

  • KMID: 2230711
  • Korean J Dermatol.
  • 1996 Feb;34(1):71-77.
BACKGROUND: Minimal erythema dose(MED), minimal melanogenic dose (MMD) and minimal phototoxic dose(MPD) of UVA-1 in Koreans has not been determined, although MED and MMD of UVB and MPD of UVA-2...
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The Effects of PUVA on the Morphologic Changes , Proliferation of Cultured Human Keratinocytes , and on the Proliferation , Melanization and Dendricity of Cultured Human Melanocytes

Jun IS, Park JK, Haw CR, Lee MH

  • KMID: 2230792
  • Korean J Dermatol.
  • 1995 Oct;33(5):886-894.
BACKGROUND: The combination of psoralen and UVA (PUVA) as a model of photochemotherap, has been used in a wicle variety of cutaneous disorders such as psoriasis, vitiligo, mycosis fungoides and...
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Effects of 8 - Methoxypsoralen ( 8 - MOP ) on the Proliferation and Melanization of Cultured Normal Human Melanocytes without UVA

Lee MH, Yoo HD, Park JK, Haw CR

  • KMID: 1930762
  • Korean J Dermatol.
  • 1994 Oct;32(5):832-837.
BACKGROUND: Psoralen has been used in the treatment of certain hypojigmentary disorders with UVA or solar irradiation. However trecent report proposed the actions of psiralens are direct and do not...
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The effect of PUVA on muose epidermal DNA synthesis studied by 5-Bromo-2-Deoxyurdine immunohistochemistry

Moon SE, Youn JI

  • KMID: 1693780
  • Korean J Dermatol.
  • 1993 Oct;31(5):738-745.
BACKGROUND: The action of ultraviolet rays on DNA causes the main photobiologic response of cells to ultraviolet rays. To study this effect, tritiated thymidine autoradiography was used. Recently 5-bromo-2deoxyuridine(BrdU), an...
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The effects of PUVA on epidermal melanocytes in C57BL mice

Ree JH, Youn JI

  • KMID: 2303598
  • Korean J Dermatol.
  • 1992 Aug;30(4):484-491.
The object of this study is to evaluate the effects of repeat,ed PUVA applications on epidermal melanocytes. The changes in the number of melanocyes is compared to the frequency of...
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Allergic contact dermatitis due to 8-methoxypsoralen(8-MOP)

Lee IJ, Park YK, Im S, Hann SK

  • KMID: 2128364
  • Korean J Dermatol.
  • 1992 Dec;30(6):897-900.
Allergic contact dermatitis due to 8-MOP is a rarely known si(ie effect of this widely used drug. Other known adverse reactions due to 8-MOP such as the oallergic dermatitis as...
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Inflammatory skin response to photochemotherapy: ear swelling response in C57BL mouse model

Ree JH, Youn JI

  • KMID: 2230898
  • Korean J Dermatol.
  • 1992 Oct;30(5):608-615.
We have observed the dark effect of 8-methoxypsoralen(8-M(P) on the viability and DNA synthesis in human lymphocyte cultures after stimulaticn with phytohemagglutinin (PHA) in the absence of ultraviolet A radiation....
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Effect of 8-methoxypsoralen on PHA-induced DNA synthesis of human lymphocyte in the absence of UVA

Chung JH, Kim KH, Youn JI, Ree JH

  • KMID: 2230897
  • Korean J Dermatol.
  • 1992 Oct;30(5):601-607.
We have observed the dark effect of 8-methoxypsoralen (8-MOP) on the viability and DNA synthesis in human lymphocyte cultures after stimulation with phytohemagglutinin (PHA) in the absence of ultraviolet A...
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Study of the skin concentrations after administration of the various phototoxic drugs

Park YK, Hann SK, Cho MY, Kim HJ, Shim SC, Choi SJ, Yun MH

The skin concentrations of 8-methoxypsoralen (8-MOP), 5-methoxypsoralen (5-MOP), and 4, 5', 8-trimethylpsoralen (TMP) were studied in the guinea pig following oral administration and bathing. The skin concentration of phototoxic drugs...
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Studies on the Effects of Various Topical Phototoxic Drugs and UVA on Melanocytes of C57 BL Mice

Park YK, Kim YC, Hann SK, Cho MY, Koo SW

One hundred sixteen C57 BL mice were painted with either 8-MOP, 5-MOP or TMP solution in concentrations of 0.02%, 0.1%, and 0.5% each and UVA irradiated. Skin biopsies were performed...
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Quantitative and Morphologic Changes of Epidermal Langerhans Cell after Photochemotherapy in Guinea Pigs

Kim SC, Park YK

We studied the number and morphologic alterations of ATPase-positive Langerhans cells (LCs) in guinea pig epidermal sheets and also performed electron microscopic observations on them following long-term systemic psoralen photochemotherapy...
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