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The Correlation between Tear Matrix Metalloproteinase-9 Concentration and Clinical Findings in Dry Eye Disease

Kim HR, Lee HK

PURPOSE: To investigate the correlation between the matrix metalloproteinase-9 (MMP-9) concentration, and subjective symptoms and objective signs in dry eye patients. METHODS: We retrospectively reviewed the medical records of 134 eyes...
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Porphyromonas gingivalis lipopolysaccharide stimulates vascular smooth muscle cell migration through signal transducer and activator of transcription 3-mediated matrix metalloproteinase-9 expression

Kim Y, Park JY, Park HJ, Kim MK, Kim YI, Bae SK, Kim HJ, Bae MK

Periodontal diseases have been associated with the development of cardiovascular diseases. Accumulating evidences have indicated that Porphyromonas gingivalis, a major periodontopathic pathogen, plays a critical role in the pathogenesis of...
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The Effect of Progesterone on Tumor Necrosis Factor-α Induced Matrix Metalloproteinase-9 in Human Choriodecidual Membranes

Choi SJ, Sohn JH, Han KH, Park EY, Kang J, Chung IB

OBJECTIVE: Progesterone is used to prevent recurrent preterm delivery, however the molecular mechanisms of its effect are incompletely understood. The objective of this study was to determine the effect of...
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S100ß, Matrix Metalloproteinase-9, D-dimer, and Heat Shock Protein 70 Are Serologic Biomarkers of Acute Cerebral Infarction in a Mouse Model of Transient MCA Occlusion

Choi JI, Ha SK, Lim DJ, Kim SD, Kim SH

OBJECTIVE: Diagnosing acute cerebral infarction is crucial in determining prognosis of stroke patients. Although many serologic tests for prompt diagnosis are available, the clinical application of serologic tests is currently...
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Chronic Cerebral Hypoperfusion Induces Alterations of Matrix Metalloproteinase-9 and Angiopoietin-2 Levels in the Rat Hippocampus

Kim MS, Choi BR, Lee YW, Kim DH, Han YS, Jeon WK, Han JS

Angiogenic factors contribute to cerebral angiogenesis following cerebral hypoperfusion, and understanding these temporal changes is essential to developing effective treatments. The present study examined temporal alterations in angiogenesis-related matrix metalloproteinase-9...
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Troglitazone Inhibits Matrix Metalloproteinase-9 Expression and Invasion of Breast Cancer Cell through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism

Hong OY, Youn HJ, Jang HY, Jung SH, Noh EM, Chae HS, Jeong YJ, Kim W, Kim CH, Kim JS

PURPOSE: Peroxisome proliferator-activated receptor γ (PPARγ) is involved in the pathology of numerous diseases including atherosclerosis, diabetes, obesity, and cancer. Matrix metalloproteinases (MMPs) play a significant role in tissue remodeling...
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Crotonis Fructus Extract Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Expression of Matrix Metalloproteinase-9 via the Activator Protein-1 Pathway in MCF-7 Cells

Song HK, Lee GS, Park SH, Noh EM, Kim JM, Ryu DG, Jung SH, Youn HJ, Lee YR, Kwon KB

PURPOSE: Metastatic cancers spread from the primary site of origin to other parts of the body. Matrix metalloproteinase-9 (MMP-9) is essential in metastatic cancers owing to its major role in...
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Plasma Levels of Matrix Metalloproteinase-9 in Children With Chronic Spontaneous Urticaria

Dilek F, Ozceker D, Ozkaya E, Tamay Z, Yazici M, Kesgin S, Kocyigit A, Guler N

PURPOSE: Chronic spontaneous urticaria (CSU) is a disease that is primarily seen in adults and is comparatively rare in children. Consequently, only a few studies have focused on the pathogenesis...
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Umbilical Cord Blood Matrix Metalloproteinase-9 Levels are associated with Funisitis

Shim SS, Kang HS, Maeng YH, Kim YD

PURPOSE: Intrauterine inflammation (IUI) is a leading cause of preterm delivery. Although matrix metalloproteinase-8 (MMP-8) and intercellular adhesion molecule-1 (ICAM-1) are known to be related with IUI, it has not...
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Dexamethasone Inhibits Interleukin-1beta-Induced Matrix Metalloproteinase-9 Expression in Cochlear Cells

Nam SI, Kwon TK

OBJECTIVES: To investigate the effect of interleukin (IL)-1beta on matrix metalloproteinase (MMP)-9 expression in cochlea and regulation of IL-1beta-mediated MMP-9 expression by dexamethasone and the molecular and signaling mechanisms involved. METHODS:...
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Role of NFkappaB in toll-like receptor 9-mediated matrix metalloproteinase-9 expression

Lee SH, Chin BR, Baek SH

  • KMID: 1814529
  • J Korean Assoc Oral Maxillofac Surg.
  • 2007 Dec;33(6):636-642.
BACKGROUND: CpG DNA plays an important role in immune cell function. This study examined whether the temporal control of toll-like receptor (TLR)9 by CpG DNA can regulate the expression of...
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Effects of (-)-Epigallocatechin-3-gallate on Brain Infarction and the Activity Change of Matrix Metalloproteinase-9 Induced by Middle Cerebral Artery Occlusion in Mice

Qian YR, Kook JH, Hwang S, Kim DK, Kim JK

  • KMID: 2285330
  • Korean J Physiol Pharmacol.
  • 2007 Jun;11(3):85-88.
Matrix metalloproteinases (MMPs) can degrade a wide range of extracellular matrix components. It has been reported that MMP-9 are activated after focal ischemia in experimental animals. (-)-Epigallocatechin-3-gallate (EGCG), a major...
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Effect of Curcumin on Cancer Invasion and Matrix Metalloproteinase-9 Activity in MDA-MB-231 Human Breast Cancer Cell

Bang MH, Kim WK

  • KMID: 2270062
  • Korean J Nutr.
  • 2006 Dec;39(8):756-761.
Curcumin has been known for its anti-proliferative and apoptotic effects on several cancer cells. We examined the inhibitory effects of curcumin on cancer cell adhesion, motility, invasion and matrix metalloproteinase-9...
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Expression of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 after Administration of Endotoxin in Diabetic Rats

Seo KH, Choi JS, Na JO, Uh ST, Kim YH, Park CS

BACKGROUND: An acute lung injury(ALI) is characterized by the recruitment, activation, and apoptosis of inflammatory cells, numerous products released by inflammatory cells such as reactive oxygen species, inflammatory mediators, and...
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The Relationship of Matrix Metalloproteinase-9 and Microbleeds on T2*-Weighted Gradient-Echo MRI in Acute Lacunar Infarction

Park CY, Koo DL, Kim HY, Koh SH, Lee KY, Lee YJ, Kim J, Kim SH

  • KMID: 2343224
  • J Korean Neurol Assoc.
  • 2006 Aug;24(4):311-317.
BACKGROUND: Hypointense cerebral lesions on T2*-weighted gradient-echo MRI (GRE) have been known to be related with microbleeds or advanced microangiopathy with potential for further bleeding. It has also been suggested...
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Analysis of Matrix Metalloproteinase-9 Expression in Renal Cell Carcinoma

Kim JY, Park TC

  • KMID: 2320168
  • Yeungnam Univ J Med.
  • 2006 Jun;23(1):82-89.
BACKGROUND: Matrix metalloproteinases (MMPs) are involved in the degradation of the extracellular matrix, which is an important step in tumor invasion and metastasis. A positive correlation between the expression of...
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The Serum Concentration of Matrix Metalloproteinase-9 in Childhood Migraine

Han MH, Kim DS, Shim JY, Shim JW, Jung HL, Park MS

  • KMID: 2329336
  • J Korean Child Neurol Soc.
  • 2006 May;14(1):24-29.
PURPOSE: Migraine is a common neurological disorder, but the mechanism has not yet been apparently discovered. Recent studies have found that migrainous headache comes from the hemodynamic changes based on...
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The Clinical Significance of the Expression of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Renal Cell Carcinoma

Kim JY, Park TC, Baek SH

PURPOSE: Matrix metalloproteinases (MMPs) are endogenous peptidases that are capable of degrading various components of the basement membranes. To evaluate the clinical significance of the expressions of MMPs in renal...
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Role of Matrix Metalloproteinase-9 in Asthma

  • KMID: 2299631
  • Korean J Asthma Allergy Clin Immunol.
  • 2006 Mar;26(1):1-9.
No Abstract available.
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Role of Matrix Metalloproteinase-9 in Asthma

Lim DH

  • KMID: 1876610
  • Pediatr Allergy Respir Dis.
  • 2006 Mar;16(1):12-22.
Variable airway obstruction, increased bronchial hyperresponsiveness, allergic inflammatory reaction and airway remodeling are main characteristics of asthma. Matrix metalloproteinases (MMPs) and their inhibitors, tissue inhibitors of metalloproteinases(TIMPs) do play important...
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