- Synergistic Effect of Flavonoids from Artocarpus heterophyllus Heartwoods on Anticancer Activity of Cisplatin Against H460 and MCF-7 Cell Lines
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Daud NN, Septama AW, Simbak N, Bakar NH, Rahmi EP
- KMID: 2468064
- Nat Prod Sci.
- 2019 Dec;25(4):311-316.
- doi: 10.20307/nps.2019.25.4.311
Artocarpus heterophyllus has been used as traditional medicine. This plant is one of the sources of flavonoid. Flavonoid compounds possessed a wide range of biological properties including anticancer. This study... -
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- p90RSK Activation Promotes Epithelial-Mesenchymal Transition in Cisplatin-Treated Triple-Negative Breast Cancer Cells
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Jin Y, Heo KS
- KMID: 2468028
- J Bacteriol Virol.
- 2019 Dec;49(4):221-229.
- doi: 10.4167/jbv.2019.49.4.221
p90 ribosomal S6 kinase (p90RSK), one of the downstream effectors in ERK1/2 pathways, shows high expression in human breast cancer tissues. However, its role in breast cancer development and drug... -
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- In Vitro and In Vivo Study on the Effect of Lysosome-associated Protein Transmembrane 4 Beta on the Progression of Breast Cancer
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Tao D, Liang J, Pan Y, Zhou Y, Feng Y, Zhang L, Xu J, Wang H, He P, Yao J, Zhao Y, Ning Q, Wang W, Jiang W, Zheng J, Wu X
- KMID: 2458859
- J Breast Cancer.
- 2019 Sep;22(3):375-386.
- doi: 10.4048/jbc.2019.22.e43
PURPOSE: Although the effect of lysosome-associated protein transmembrane 4 beta (LAPTM4B) on the proliferation, migration, and invasion of breast cancer (BC) cells has already been studied, its specific role in... -
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- Cytotoxic Lactones from the Pericarps of Litsea japonica
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Ngo QM, Cao TQ, Woo MH, Min BS
- KMID: 2443099
- Nat Prod Sci.
- 2019 Mar;25(1):23-27.
- doi: 10.20307/nps.2019.25.1.23
From the pericarps of Litsea japonica (Thunb.) Jussieu, eighteen butanolide derivatives (1 – 18) were evaluated for their cytotoxic activity against HeLa, HL-60, and MCF-7 cells. Compounds 1 – 9... -
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- Imidazole Antifungal Drugs Inhibit the Cell Proliferation and Invasion of Human Breast Cancer Cells
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Bae SH, Park JH, Choi HG, Kim H, Kim SH
- KMID: 2421728
- Biomol Ther.
- 2018 Sep;26(5):494-502.
- doi: 10.4062/biomolther.2018.042
Breast cancer is currently the most prevalent cancer in women, and its incidence increases every year. Azole antifungal drugs were recently found to have antitumor efficacy in several cancer types.... -
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- Mechanical Alteration Associated With Chemotherapeutic Resistance of Breast Cancer Cells
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Park S
- KMID: 2417372
- J Cancer Prev.
- 2018 Jun;23(2):87-92.
- doi: 10.15430/JCP.2018.23.2.87
BACKGROUND: The mechanical deformability of cancer cells has attracted particular attention as an emerging biomarker for the prediction of anti-cancer drug sensitivity. Nevertheless, it has not been possible to establish... -
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- Panduratin A Inhibits Cell Proliferation by Inducing G0/G1 Phase Cell Cycle Arrest and Induces Apoptosis in Breast Cancer Cells
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Liu Q, Cao Y, Zhou P, Gui S, Wu X, Xia Y, Tu J
- KMID: 2421743
- Biomol Ther.
- 2018 May;26(3):328-334.
- doi: 10.4062/biomolther.2017.042
Because of the unsatisfactory treatment options for breast cancer (BC), there is a need to develop novel therapeutic approaches for this malignancy. One such strategy is chemotherapy using non-toxic dietary... -
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- Troglitazone Inhibits Matrix Metalloproteinase-9 Expression and Invasion of Breast Cancer Cell through a Peroxisome Proliferator-Activated Receptor γ-Dependent Mechanism
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Hong OY, Youn HJ, Jang HY, Jung SH, Noh EM, Chae HS, Jeong YJ, Kim W, Kim CH, Kim JS
- KMID: 2441865
- J Breast Cancer.
- 2018 Mar;21(1):28-36.
- doi: 10.4048/jbc.2018.21.1.28
PURPOSE: Peroxisome proliferator-activated receptor γ (PPARγ) is involved in the pathology of numerous diseases including atherosclerosis, diabetes, obesity, and cancer. Matrix metalloproteinases (MMPs) play a significant role in tissue remodeling... -
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- Crotonis Fructus Extract Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Expression of Matrix Metalloproteinase-9 via the Activator Protein-1 Pathway in MCF-7 Cells
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Song HK, Lee GS, Park SH, Noh EM, Kim JM, Ryu DG, Jung SH, Youn HJ, Lee YR, Kwon KB
- KMID: 2438989
- J Breast Cancer.
- 2017 Sep;20(3):234-239.
- doi: 10.4048/jbc.2017.20.3.234
PURPOSE: Metastatic cancers spread from the primary site of origin to other parts of the body. Matrix metalloproteinase-9 (MMP-9) is essential in metastatic cancers owing to its major role in... -
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- Reserpine treatment activates AMP activated protein kinase (AMPK)
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Park R, Lee KI, Kim H, Jang M, Ha TK, Oh WK, Park J
- KMID: 2393795
- Nat Prod Sci.
- 2017 Sep;23(3):157-161.
- doi: 10.20307/nps.2017.23.3.157
Reserpine is a well-known medicine for the treatment of hypertension, however the role of reserpine in cell signaling is not fully understood. Here, we report that reserpine treatment induces the... -
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- Inhibition of Nicotinamide Phosphoribosyltransferase Induces Apoptosis in Estrogen Receptor-Positive MCF-7 Breast Cancer Cells
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Alaee M, Khaghani S, Behroozfar K, Hesari Z, Ghorbanhosseini SS, Nourbakhsh M
- KMID: 2379395
- J Breast Cancer.
- 2017 Mar;20(1):20-26.
- doi: 10.4048/jbc.2017.20.1.20
PURPOSE: Tumor cells have increased turnover of nicotinamide adenine dinucleotide (NADâº), the main coenzyme in processes including adenosine diphosphate-ribosylation, deacetylation, and calcium mobilization. NAD⺠is predominantly synthesized in human cells... -
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- Diarylbutane-type Lignans from Myristica fragrans (Nutmeg) show the Cytotoxicity against Breast Cancer Cells through Activation of AMP-activated Protein Kinase
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Le TV, Nguyen PH, Choi HS, Yang JL, Kang KW, Ahn SG, Oh WK
- KMID: 2376495
- Nat Prod Sci.
- 2017 Mar;23(1):21-28.
- doi: 10.20307/nps.2017.23.1.21
In our program to search for new AMP-activated protein kinase (AMPK) activators from plants that exert potential anticancer property, we found that an EtOAc extract of Myristica fragrans (nutmeg) activated... -
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- Estrogenic activity of zinc pyrithione: an in vivo and in vitro study
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Yoon KS, Youn N, Gu H, Kwack SJ
- KMID: 2411236
- Environ Health Toxicol.
- 2017 ;32(1):e2017004.
- doi: 10.5620/eht.e2017004
Zinc pyrithione (ZP) is commonly used to prevent dandruff and seborrheic dermatitis. Many consumers are exposed daily to high doses of ZP, causing serious concerns about its toxicity. The reproductive... -
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- Effects of Triterpenoids from Luvunga scandens on Cytotoxic, Cell Cycle Arrest and Gene Expressions in MCF-7 Cells
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Taher M, Al-Zikri P, Susanti D, Ichwan SJ, Rezali MF
- KMID: 2366699
- Nat Prod Sci.
- 2016 Dec;22(4):293-298.
- doi: 10.20307/nps.2016.22.4.293
Plant-derived triterpenoids commonly possesses biological properties such as anti-inflammatory, anti-microbial, anti-viral and anti-cancer. Luvunga scandens is one of the plant that produced triterpenoids. The aims of the study was to... -
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- LncRNA Taurine-Upregulated Gene 1 Promotes Cell Proliferation by Inhibiting MicroRNA-9 in MCF-7 Cells
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Zhao XB, Ren GS
- KMID: 2362921
- J Breast Cancer.
- 2016 Dec;19(4):349-357.
- doi: 10.4048/jbc.2016.19.4.349
PURPOSE: This study was designed to investigate the role of taurine-upregulated gene 1 (TUG1) in MCF-7 breast cancer cells and the molecular mechanism involved in the regulation of microRNA-9 (miR-9). METHODS:... -
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- Cell-in-Cell Death Is Not Restricted by Caspase-3 Deficiency in MCF-7 Cells
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Wang S, He M, Li L, Liang Z, Zou Z, Tao A
- KMID: 2413947
- J Breast Cancer.
- 2016 Sep;19(3):231-241.
- doi: 10.4048/jbc.2016.19.3.231
PURPOSE: Cell-in-cell structures are created by one living cell entering another homotypic or heterotypic living cell, which usually leads to the death of the internalized cell, specifically through caspase-dependent cell... -
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- Cytotoxic, Anti-Inflammatory and Adipogenic Effects of Inophyllum D, Calanone, Isocordato-oblongic acid, and Morelloflavone on Cell Lines
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Taher M, Aminuddin , Susanti D, Aminudin N, On S, Ahmad F, Hamidon H
- KMID: 2328878
- Nat Prod Sci.
- 2016 Jun;22(2):122-128.
- doi: 10.20307/nps.2016.22.2.122
This paper reports in vitro cytotoxic, anti-inflammatory and adipocyte diffentiation with adipogenic effects of coumarins inophyllum D (1) and calanone (2), and a chromanone carboxylic acid namely isocordato-oblongic acid (3)... -
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- Caveolin-1 Modulates Docetaxel-Induced Cell Death in Breast Cancer Cell Subtypes through Different Mechanisms
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Kang J, Park JH, Lee HJ, Jo U, Park JK, Seo JH, Kim YH, Kim I, Park KH
- KMID: 2454350
- Cancer Res Treat.
- 2016 Apr;48(2):715-726.
- doi: 10.4143/crt.2015.227
PURPOSE: Caveolin-1 (CAV-1) expression is more associated with basal-like cancers than estrogen receptor- or ErbB-2-expressing breast cancers. However, the biological relevance of different levels of CAV-1 expression according to subtype... -
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- Silibinin-Induced Apoptosis and Downregulation of MicroRNA-21 and MicroRNA-155 in MCF-7 Human Breast Cancer Cells
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Zadeh MM, Motamed N, Ranji N, Majidi M, Falahi F
- KMID: 2176320
- J Breast Cancer.
- 2016 Mar;19(1):45-52.
- doi: 10.4048/jbc.2016.19.1.45
PURPOSE: MicroRNAs (miRNAs) have received much attention owing to their aberrant expression in various stages of cancer. In many biological processes, miRNAs negatively regulate gene expression, and may be useful... -
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- Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells
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Lee HM, Moon A
- KMID: 2170542
- Biomol Ther.
- 2016 Jan;24(1):62-66.
- doi: 10.4062/biomolther.2015.172
Amygdalin, D-mandelonitrile-beta-D-glucoside-6-beta-glucoside, belongs to aromatic cyanogenic glycoside group derived from rosaceous plant seed. Mounting evidence has supported the anti-cancer effects of amygdalin. However, whether amygdalin indeed acts as an anti-tumor... -
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