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Urinary neutrophil gelatinase-associated lipocalin: a marker of urinary tract infection among febrile children

Moon JH, Yoo KH, Yim HE

Background: Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a valuable biomarker of urinary tract infection (UTI) in children. Purpose: This study aimed to compare the diagnostic accuracy of urinary NGAL (uNGAL)...
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Influence of Postconceptional Age on the Renal Biomarkers in Very-Low-Birth-Weight Infants

Lee RS, Shin SY, Jung WH, Park JH

Purpose: We investigated whether consecutive levels of new emerging renal biomarkers, including serum cystatin C (CysC) and urinary neutrophil gelatinase-associated lipocalin (NGAL)/creatinine (Cr) ratio, were affected by postconceptional age in...
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Serum lipocalin-2 is a potential biomarker for the clinical diagnosis of nonalcoholic steatohepatitis

Xu G, Wang YM, Ying MM, Chen SD, Li ZR, Ma HL, Zheng MH, Wu J, Ding C

Background/Aims: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) characterized by hepatic steatosis, inflammation, hepatocellular injury, and fibrosis. We aimed to investigate the usefulness of...
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Associations of Plasma Neutrophil Gelatinase-associated Lipocalin, Anemia, and Renal Scarring in Children with Febrile Urinary Tract Infections

Lee JH, Yim HE, Yoo KH

BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL), a bacteriostatic agent, is known to inhibit erythropoiesis leading to anemia. We aimed to investigate the associations of NGAL, anemia, and renal scarring in children...
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Effects of short-term atorvastatin use in patients with calcium stones: A randomized placebo-controlled clinical trial

Taheri F, Taheri M, Basiri A, Khoshdel A, Samadian F, Tavasoli S

PURPOSE: A few experimental and observational studies have reported that atorvastatin prevents calcium oxalate stone formation. Our study is the first to investigate the effect of atorvastatin on 24-hour urinary...
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Atorvastatin pretreatment attenuates kainic acid-induced hippocampal neuronal death via regulation of lipocalin-2-associated neuroinflammation

Jin Z, Jung Y, Yi CO, Lee JY, Jeong EA, Lee JE, Park KJ, Kwon OY, Lim BH, Choi NC, Roh GS

Statins mediate vascular protection and reduce the prevalence of cardiovascular diseases. Recent work indicates that statins have anticonvulsive effects in the brain; however, little is known about the precise mechanism...
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Perspectives in Lipocalin-2: Emerging Biomarker for Medical Diagnosis and Prognosis for Alzheimer's Disease

Song J, Kim OY

Lipocalin-2 (LCN2), a secreted glycoprotein belonging to the lipocalin superfamily was reported to participate in various biological processes including cell migration, cell survival, inflammatory responses, and insulin sensitivity. LCN2 is...
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Serum Concentrations of Insulin, Ghrelin, Adiponectin, Leptin, Leptin Receptor and Lipocalin-2 in Children with Celiac Disease Who Do and Do Not Adhere to a Gluten-Free Diet

Janas RM, Rybak A, Wierzbicka-Rucińska A, Socha P, Śnitko R, Szaflarska-Popławska A, Stolarczyk A, Oralewska , Cytra-Jarocka E, Iwańczak , Grzybowska-Chlebowczyk U, Cichy W, Czaja-Bulsa G, Socha J

BACKGROUND/AIMS: The roles of the many bioactive peptides in the pathogenesis of celiac disease remain unclear. To evaluate the serum concentrations of insulin, ghrelin, adiponectin, leptin, leptin receptor, and lipocalin-2...
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Lipocalin-2 Acts as a Neuroinflammatogen in Lipopolysaccharide-injected Mice

Jin M, Jang E, Suk K

Lipocalin-2 (LCN2) is a key mediator of various cellular processes. Recent studies have indicated that LCN2 also plays an important role in central nervous system (CNS) injuries and neurological diseases,...
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Regulation of Iron and Its Significance in Obesity and Complications

Chan YK, Sung HK, Sweeney G

Iron is an essential micronutrient with important roles in many critical physiological processes, especially as a structural component of hemoglobin responsible for oxygen transport. Iron homeostasis is tightly regulated, yet...
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Adipose Gene Expression Profiles Related to Metabolic Syndrome Using Microarray Analyses in Two Different Models

Yoo HJ, Hwang HJ, Jung TW, Ryu JY, Hong HC, Choi HY, Baik SH, Choi KM

BACKGROUND: Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist has a wide-ranging influence on multiple components of metabolic syndrome. The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is a useful animal model of metabolic...
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Acute Phase Protein Lipocalin-2 Is Associated with Formalin-induced Nociception and Pathological Pain

Jha MK, Jeon S, Jin M, Lee WH, Suk K

Lipocalin-2 (LCN2) is an acute-phase protein induced by injury, infection, or other inflammatory stimuli. LCN2 binds small hydrophobic ligands and interacts with cell surface receptor to regulate diverse cellular processes....
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