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Impairment of AMPK-α2 augments detrusor contractions in bladder ischemia

Yang JH, Niu W, Li Y, Azadzoi KM

Purpose: Ischemia disrupts cellular energy homeostasis. Adenosine monophosphate-activated protein kinase alpha-2 (AMPK-α2) is a subunit of AMPK that senses cellular energy deprivation and signals metabolic stress. Our goal was to...
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Adipose-Derived Stem Cell Exosomes Promoted Hair Regeneration

Wu J, Yang Q, Wu S, Yuan R, Zhao X, Li Y, Wu W, Zhu N

BACKGROUND: Some scholars have found that dermal papilla spheroid–derived exosomes could promote the development of hair follicles. However, whether adipose-derived stem cell exosomes (ADSC-Exos) have a similar effect on hair...
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A Five-step Systematic Therapy for Treating Plugged Ducts and Mastitis in Breastfeeding Women: A Case-Control Study

Yao Y, Long T, Pan Y, Li Y, Wu L, Fu B, Ma H

Purpose This study aimed to describe the clinical response to five-step systematic therapy (FSST) in the management of plugged ducts and mastitis. FSST was a comprehensive milk stasis dredging treatment, which...
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Transthyretin Cardiac Amyloidosis: A Case Report

Chin ZY, Chew D, Khor LY, Liew C

We report a case of a 63-year-old Chinese female with multi-systemic amyloidosis associated with transthyretin mutation. She presented with gastrointestinal symptoms, sensorimotor polyneuropathy, and loss of weight. Her initial CT...
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Effect of Physical Activity on the Association Between Dietary Fiber and Constipation: Evidence From the National Health and Nutrition Examination Survey 2005-2010

Li Y, Tong WD, Qian Y

  • KMID: 2517540
  • J Neurogastroenterol Motil.
  • 2021 Jul;27(3):440.
  • doi: 10.5056/jnm20051E
No abstract available
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Discontinuation Rate of Newly Prescribed Donepezil in Alzheimer’s Disease Patients in Asia

Park KH, Yang Y, Chen C, Shim YS, Dominguez JC, Lee CN, Kang K, Kim HJ, Jeong SK, Jeong JH, Hong Z, Yoon SJ, Zhang ZX, Kim EJ, Jang JW, Li Y, Xu Y, Lin YT, Qu Q, Hu CJ, Chou CH, Fan D, Kandiah N, Yang YH, Lau Ci, Chu LW, Wang H, Jung S, Choi SH, Kim S

Background and Purpose The rate of donepezil discontinuation and the underlying reasons for discontinuation in Asian patients with Alzheimer’s disease (AD) are currently unknown. We aimed to determine the treatment...
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Whole body hypoxic preconditioning-mediated multiorgan protection in db/db mice via nitric oxide-BDNF-GSK-3β-Nrf2 signaling pathway

Li Y, Huang Y, Cheng X, He Y, Hu X

The beneficial effects of hypoxic preconditioning are abolished in the diabetes. The present study was designed to investigate the protective effects and mechanisms of repeated episodes of whole body hypoxic...
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Development of a simple nomogram to estimate risk for intraoperative complications before partial nephrectomy based on the Mayo Adhesive Probability score combined with the RENAL nephrometry score

Tan X, Jin D, Hu J, Zhang W, Zhou Y, Li Y, Zhang Y, Wu J

Purpose: This study aimed to develop a simple nomogram based on the Mayo Adhesive Probability (MAP) score combined with the RENAL nephrometry score (RNS) to predict intraoperative complications before partial...
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Molecular detection and genetic diversity of bovine papillomavirus in dairy cows in Xinjiang, China

Meng Q, Ning C, Wang L, Ren Y, Li J, Xiao C, Li Y, Li Z, He Z, Cai X, Qiao J

Background: Bovine papillomatosis is a type of proliferative tumor disease of skin and mucosae caused by bovine papillomavirus (BPV). As a transboundary and emerging disease in cattle, it poses a...
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Identification of a mimotope of an infectious bronchitis virus S1 protein

Zhou J, Li J, Li Y, Liu H, Qi Y, Wang A

The S1 protein of the infectious bronchitis virus (IBV) is a major structural protein that induces the production of the virus-neutralization antibodies. The monoclonal antibody against the IBV M41 S1...
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Long Non-Coding RNA NORAD Inhibits Breast Cancer Cell Proliferation and Metastasis by Regulating miR-155-5p/ SOCS1 Axis

Liu W, Zhou X, Li Y, Jiang H, Chen A

Purpose: Non-coding RNA activated by DNA damage (NORAD) has been reported to be a cancer-related long non-coding RNA (lncRNA) implicated in the progression of several cancers; however, its role in...
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Anatomical Study of the Accessory Tendon of the Extensor Hallucis Longus Muscle and Its Clinical Application

Li Y, Zhang JY, Zhao XY, Pan LY, Jin DH, Xu HX, Cui HZ, Liu YQ, Qin XZ, Li Q

Background: The accessory tendon of the extensor hallucis longus (ATEHL) muscle is a common abnormal structure, and its clinical significance remains debatable. In this study, we provide the incidence of...
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Mangiferin ameliorates cardiac fibrosis in D-galactose-induced aging rats by inhibiting TGF-β/p38/MK2 signaling pathway

Cheng J, Ren C, Cheng R, Li Y, Liu P, Wang W, Liu L

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Excessive copper in feed not merely undermines animal health but affects food safety

Ma Z, Li Y, Han Z, Liu Z, Wang H, Meng F, Liu S, Chen D, Liu M

Background: Blackened intestines in slaughtered pigs have been commonly observed in China in recent years. However, no cause has been reported. Objectives: We attempted to determine whether the blackening of the...
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Valproic Acid Enhance Reprogramming of Bactrian Camel Cells through Promoting the Expression of Endogenous Gene c-Myc and the Process of Angiogenesis

Li Z, Ge W, Li Y, Zhang Y, Zhao X, Hu J

Background and Objectives: Induced pluripotent stem cells (iPSCs) are usually generated by reprogramming differentiated cells through the introduction of specific transcription factors, but this is a difficult and inefficient process. Valproic...
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Two New Species in the Family Cunninghamellaceae from China

Zhao H, Zhu J, Zong TK, Liu XL, Ren LY, Lin Q, Qiao M, Nie Y, Zhang ZD, Liu XY

The species within the family Cunninghamellaceae are widely distributed and produce important metabolites. Morphological studies along with a molecular phylogeny based on the internal transcribed spacer (ITS) and large subunit...
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Mangiferin ameliorates cardiac fibrosis in D-galactose-induced aging rats by inhibiting TGF-β/p38/MK2 signaling pathway

Cheng J, Ren C, Cheng R, Li Y, Liu P, Wang W, Liu L

Aging is the process spontaneously occurred in living organisms. Cardiac fibrosis is a pathophysiological process of cardiac aging. Mangiferin is a wellknown C-glucoside xanthone in mango leaves with lots of...
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Paeoniflorin treatment regulates TLR4/NF-κB signaling, reduces cerebral oxidative stress and improves white matter integrity in neonatal hypoxic brain injury

Yang F, Li Y, Sheng X, Liu Y

Neonatal hypoxia/ischemia (H/I), injures white matter, results in neuronal loss, disturbs myelin formation, and neural network development. Neuroinflammation and oxidative stress have been reported in neonatal hypoxic brain injuries. We...
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KAT8/MOF-Mediated Anti-Cancer Mechanism of Gemcitabine in Human Bladder Cancer Cells

Zhu H, Wang Y, Wei T, Zhao X, Li F, Li Y, Wang F, Cai Y, Jin J

Histone acetylation is a well-characterized epigenetic modification controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). Imbalanced histone acetylation has been observed in many primary cancers. Therefore, efforts have been...
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Effects of resveratrol on the inflammatory response and renal injury in hyperuricemic rats

Xiao B, Ma W, Zheng Y, Li Z, Li D, Zhang Y, Li Y, Wang D

BACKGROUND/OBJECTIVES: Hyperuricemic nephropathy is a common cause of acute kidney injury. Resveratrol can ameliorate kidney injury, but the explicit mechanism remains unclear. We investigated the effects of resveratrol on the inflammatory...
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