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Historical Review of Leptospirosis in the Korea (1945 – 2015)

Kim MJ

Leptospirosis is a widespread worldwide zoonosis. Human leptospirosis was first identified in the Korea in 1984 as the cause of “epidemic pulmonary hemorrhagic fever of unknown etiology” that occurred sporadically...
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A Study on the Febrile Illness in Autumn among Farmers in Gyeongju-si: Scrub typhus, Leptospirosis, HFRS

Kim DS, Acharya D, Yoo SJ, Park JH, Lee K

OBJECTIVES: This study aimed to assess the status of Scrub typhus, Leptospirosis and HFRS(hemorrhagic fever with renal syndrome) among farmers with febrile illness. METHODS: We involved a total of 841 farmers...
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Leptospirosis as Unusual Trigger of Systemic Lupus Erythematosus

Lee J, Kim YR, Yoon CH

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder of an unknown origin. The role of leptospirosis as a triggering factor for SLE is unknown. This paper reports an uncommon...
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Survey and Phylogenetic Analysis of Rodents and Important Rodent-Borne Zoonotic Pathogens in Gedu, Bhutan

Phuentshok Y, Dorji K, Zangpo T, Davidson S, Takhampunya R, Tenzinla T, Dorjee C, Morris RS, Jolly PD, Dorjee S, McKenzie J

Rodents are well-known reservoirs and vectors of many emerging and re-emerging infectious diseases, but little is known about their role in zoonotic disease transmission in Bhutan. In this study, a...
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Pharmacokinetics of enrofloxacin HCl-2Hâ‚‚O (Enro-C) in dogs and pharmacokinetic/pharmacodynamic Monte Carlo simulations against Leptospira spp.

Sumano H, Ocampo L, Tapia G, Mendoza CD, Gutierrez

Pharmacokinetic/pharmacodynamic (PK/PD) ratios of reference enrofloxacin (Enro-R) and enrofloxacin as HCl-2H₂O (Enro-C), as well as Monte Carlo simulations based on composite MIC₅₀ and MIC₉₀ (MIC, minimum inhibitory concentration) vs. Leptospira...
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Evaluation of a Commercial Immuno-Chromatographic Assay Kit for Rapid Detection of IgM Antibodies against Leptospira Antigen in Human Serum

Amran F, Liow YL, Halim NA

Leptospirosis is a febrile zoonotic disease. Routine diagnosis of leptospirosis is based on the detection of specific antibodies with serological tests. The aim of our study was to determine the...
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Evaluation of safety and immunogenicity of a new octavalent inactivated vaccine containing porcine parvovirus, erysipelas, and leptospira

Kim K, Choi JY, Park SJ, Hahn TW

Porcine parvovirus, Erysipelothrix (E.) rhusiopathiae, and Leptospira (L.) interrogans are considered major etiologic agents of reproductive failure in pigs, causing economic loss in the swine industry. In this study, the...
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Clinical Evaluation of Rapid Diagnostic Test Kit Using the Polysaccharide as a Genus-Specific Diagnostic Antigen for Leptospirosis in Korea, Bulgaria, and Argentina

Lee JW, Park S, Kim SH, Christova , Jacob P, Vanasco NB, Kang YM, Woo YJ, Kim MS, Kim YJ, Cho MK, Kim YW

Leptospirosis, a zoonotic disease that is caused by many serovars which are more than 200 in the world, is an emerging worldwide disease. Accurate and rapid diagnostic tests for leptospirosis...
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An epidemiological comparative study on diagnosis of rodent leptospirosis in Mazandaran Province, northern Iran

Esfandiari B, Pourshafie MR, Gouya MM, Khaki P, Mostafavi , Darvish J, Bidhendi S, Hanifi H, Nahrevanian H

OBJECTIVES: Leptospirosis is a zoonosis caused by leptospires, in which transmission occurs through contact with contaminated biological fluids from infected animals. Rodents can act as a source of infection for...
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Four Cases of Severe Fever with Thrombocytopenia Syndrome Occurring in Jeju

Heo ST, Cheon M, Kim JW

  • KMID: 2246370
  • Korean J Dermatol.
  • 2014 Mar;52(3):173-177.
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel SFTS bunyavirus (SFTSV), a member of the genus Phlebovirus in the family Bunyaviridae. SFTSV is...
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Leptospirosis in the Republic of Korea: Historical Perspectives, Current Status and Future Challenges

Kim MJ

Leptospirosis is an important public health problem in the Republic of Korea (ROK), occurring sporadically or in outbreaks during the autumn season. Wild rodents, Apodemus agrarius, have been mainly involved...
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Molecular Characterization of sca Genes Found in Orientia tsutsugamushi Genome

Ha NY, Choi MS, Cho NH

Scrub typhus is an acute, febrile illness caused by Orientia tsutsugamushi infection and it is one of the main causes of acute febrile illness in the Asian-Pacific region. The incidence...
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Work-related hazards among farmers

Kwon SC, Lee SJ, Jeong M

  • KMID: 2342144
  • J Korean Med Assoc.
  • 2012 Nov;55(11):1046-1053.
Farmers have suffered from a variety of work-related injuries and diseases. They are exposed to a number of hazards related to farming activity. Farm machines like tractors and small cultivators...
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Evaluation and comparison of native and recombinant LipL21 protein-based ELISAs for diagnosis of bovine leptospirosis

Joseph S, Thomas N, Thangapandian E, Singh VP, Verma R, Srivastava SK

A 21-kDa leptospiral lipoprotein (LipL21) was evaluated for its diagnostic potential to detect bovine leptospirosis by ELISA. Both native LipL21 (nLipL21) and recombinant LipL21 (rLipL21) proteins were tested and compared...
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Emerging Infectious Diseases in the Republic of Korea

Oh MD

Many infectious diseases have emerged or re-emerged during the past 50 years in the Republic of Korea. Some of these are new infectious diseases delivered by new or newly recognized...
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Rhabdomyolysis Induced Acute Kidney Injury in a Patient with Leptospirosis

Choi YJ, Park JM, Jung YH, Nam JH, Chung HH, Kim TW, Cho KH, Do JY, Yun KW, Park JW

  • KMID: 2320087
  • Yeungnam Univ J Med.
  • 2011 Jun;28(1):54-59.
Leptospirosis is a spirochetal infectious disease caused by Leptospira interrogans, and may vary in degree from an asymptomatic infection to a severe and fatal illness. The kidney is one of...
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A Case of Plasmodium vivax Malaria Complicated with Acute Renal Failure, Jaundice and Thrombocytopenia

Kim HJ, Lee SH, Koo TY, Kim KM, Jang SS, Lee SK

  • KMID: 2080121
  • Korean J Nephrol.
  • 2010 Nov;29(6):792-795.
Malaria is caused by four species of the genus Plasmodium. Plasmodium vivax malaria is the most common malarial infection in Korea and usually has benign clinical course. However, serious complications...
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A case report of concurrent leptospirosis and salmonellosis infection

Song EH, Kim MJ, Chon HR, Ko BJ, Seo JY, Jeong ES, Choi SH

  • KMID: 2259107
  • Korean J Med.
  • 2010 Sep;79(3):331-334.
A 37-year-old male patient presented with a fever, chills, and abdominal pain. The patient was diagnosed with Typhoid fever based on blood culture, but did not clinically respond to standard...
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Correlations Between Climate Change-Related Infectious Diseases and Meteorological Factors in Korea

Kim SH, Jang JY

OBJECTIVES: Infectious diseases are known to be affected by climate change. We investigated if the infectious diseases were related to meteorological factors in Korea. METHODS: Scrub typhus, hemorrhagic fever with...
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Clinical features of leptospirosis experienced in a university hospital between 2001 and 2007

Kang SJ, Lee KJ, Park KH, Jung SI

  • KMID: 2258369
  • Korean J Med.
  • 2009 Oct;77(4):453-460.
BACKGROUND/AIMS: Leptospirosis is a zoonotic disease of global importance. In addition, pulmonary involvement of this disease has been increasingly reported in recent decades. The present study was performed to analyze...
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