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A Case of Pseudohypoparathyroidism Type Ib Caused by Aberrant Methylation in the GNAS Complex Locus

Jo SJ, Han E, Jang W, Chae H, Kim Y, Lee GD, Cho WK, Suh BK, Kim M

  • Lab Med Online.
  • 2017 Apr;7(2):83-87.
  • doi: 10.3343/lmo.2017.7.2.83
Pseudohypoparathyroidism (PHP) is a rare disorder caused by genetic and epigenetic aberrations in the GNAS complex locus resulting in impaired expression of stimulatory G protein (Gsα). PHP type Ib (PHP-Ib)...
Two Clinical Cases of Anti-Di(b) with Di(a+b-) Phenotypes: Practical Need for Rare Blood Donor Registry Program in Korea

Lee MY, Park TS, Oh SH, Kim S, Kim HO

  • Lab Med Online.
  • 2017 Apr;7(2):79-82.
  • doi: 10.3343/lmo.2017.7.2.79
Here, we report two cases of identified anti-Di(b) antibodies with rare Di(a+b−) blood types from two different hospitals in Korea. Di(b) mismatched transfusion could cause a hemolytic transfusion reaction. However,...
Comparison and Evaluation of Diagnostic Assays for Clostridium difficile Infection

Kim KB, Kim DH, Lee W, Ha JS, Ryoo NH, Jeon DS, Kim JR

  • Lab Med Online.
  • 2017 Apr;7(2):73-78.
  • doi: 10.3343/lmo.2017.7.2.73
BACKGROUND: Clostridium difficile is a leading causative microorganism of pseudomembranous colitis (PMC) and antibiotic-associated diarrhea. In patients who have a history of antibiotic use and diarrhea, the presence of the...
Proposal of Modified HIL-indices for Determining Hemolysis, Icterus and Lipemia Interference on the Beckman Coulter AU5800 Automated Platform

Lim YK, Cha YJ

  • Lab Med Online.
  • 2017 Apr;7(2):66-72.
  • doi: 10.3343/lmo.2017.7.2.66
BACKGROUND: The amount of interference due to hemolysis, bilirubin, and lipemia can be measured on the AU5800 autoanalyzer (Beckman Coulter, USA) by spectrophotometry. This is reported as semi-quantitative indices, specifically...
Analytical Performance of Bio-Rad D-100 on a Hemoglobin A1c Assay

Liu C, Choi E, Bae IC, Lee SG, Kim JH

  • Lab Med Online.
  • 2017 Apr;7(2):59-65.
  • doi: 10.3343/lmo.2017.7.2.59
BACKGROUND: Hemoglobin A1c (HbA1c) is considered a marker useful for the follow-up and diagnosis of diabetes and implies the importance of reliable assay methods that are traceable to a reference...
Origins and History of Laboratory Medicine

Lee HJ, Oh SH, Chang CL

  • Lab Med Online.
  • 2017 Apr;7(2):53-58.
  • doi: 10.3343/lmo.2017.7.2.53
Medical diagnostics plays a significant role in clinical decisions. The first medical laboratory test to be developed was urine analysis, in which urine properties were analyzed for diagnosis. Urine analysis...

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