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Atypical Wegener's Granulomatosis Accompanied with Rheumatoid Arthritis: A Case Report

Song SD, Kim TY

Wegener's granulomatosis (WG) is highly correlated with cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCA). Patients with rheumatoid arthritis (RA) rarely contract WG. Although several concurrent cases have been reported overseas, there are...
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A Case of Acute Myeloid Leukemia Developing after Treatment for Brucellosis with Pancytopenia

Kim SH, Kim KP, Han S, Kim YR, Kang SH

Human brucellosis is an important zoonotic disease and has a wide clinical spectrum. Nonspecific hematologic abnormalities related to brucellosis are frequently found, but pancytopenia is uncommon. Malignant diseases have been...
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Hepcidin Level and Iron Parameters in Patients with Chronic Kidney Disease

Seo JY, Song YH, Park MJ, Kim MJ, Seo YH, Ahn JY, Kim KH, Jeong JH, Chung W, Park PW

BACKGROUND: Hepcidin, a key regulator of iron homeostasis, is associated with iron metabolism imbalance in patients with chronic kidney disease (CKD). However, serum hepcidin level in anemic patients with CKD...
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Diagnostic Utility of Serum Cytokeratin Fragment 21-1 in Patients with Lung Cancer

Song S, Yoo EH, Cho HJ

BACKGROUND: Lung cancer is the most lethal malignant neoplasm in the world. Serum cytokeratin fragment 21-1 (Cyfra 21-1) is a valuable tumor marker for detection of lung cancer, and it...
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Platelet Activation Markers (beta-thromboglobulin and platelet factor 4) and Clopidogrel Drug Response in Patients with Myocardiac Infarction

Park Y, Kim J, Jung J, Kwon K, Koo S

BACKGROUND: Dual antiplatelet therapy (aspirin and clopidogrel) is used to prevent adverse cardiac events in patients undergoing percutaneous coronary intervention (PCI). Some patients do not respond adequately to clopidogrel. Beta-thromboglobulin...
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Evaluation of Platelet count by the CELL-DYN Sapphire CD61 Immunoplatelet Method in Patients with Hematologic Diseases Receiving Chemotherapy

Kim BR, Choi JL, Kim JE, Woo KS, Kim KH, Kim JM, Kim SH, Han JY

BACKGROUND: The automated hematologic analyzer has increased the precision and accuracy for platelet counting. However, spurious elevations of automated platelet counts occur occasionally in patients receiving chemotherapy or radiotherapy for...
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Evaluation of the Effectiveness of the Heavy-Light Chain Quantitative Test

Kim JH, Choi WJ, Lee M, Shin HW, Cheong JW, Kim JW

BACKGROUND: The heavy-light chain (HLC) quantitative test can identify and quantify the heavy and light chains of each immunoglobulin class. The purpose of this study was to evaluate the effectiveness...
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Novel Non-contiguous Duplications in the DMD Gene in Five Patients with Duchenne Muscular Dystrophy

Rim JH, Cho SM, Yu N, Lee KA

BACKGROUND: Muscular dystrophy is an X-linked recessive disorder caused by mutations in the DMD gene. Muscular dystrophy is classified into 2 types; Duchenne muscular dystrophy (DMD), which has severe clinical...
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Legal and Ethical Use of Biospecimens in Research Following Major Revision of the Bioethics and Safety Act

Chang YJ, Kong SY

The recent revision of the Bioethics and Safety Act has created some confusion as to the appropriate use of biospecimens in research. Here, to avoid misunderstandings, we outline the changes...
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