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Translation: Companion Biomarkers: Paving the Pathway to Personalized Treatment for Cancer

Duffy MJ, Crown J

  • Lab Med Online.
  • 2015 Jan;5(1):44-54.
  • doi: 10.3343/lmo.2015.5.1.44
BACKGROUND: Companion biomarkers are biomarkers that are used in combination with specific therapies and that prospectively help predict likely response or severe toxicity. In this article we review the role...
A Case of GNAS1 Mutation in Pseudohypoparathyroidism Type Ia

Park G, Kim JH, Rhie SH, Lee ES, Noh SE

  • Lab Med Online.
  • 2015 Jan;5(1):38-43.
  • doi: 10.3343/lmo.2015.5.1.38
Pseudohypoparathyroidism (PHP) is a group of genetic disorders in which the kidneys fail to respond to parathyroid hormone. Genetic defects in the GNAS complex locus lead to reduced Gsalpha (alpha-subunit...
A Case of Plasmodium malariae Infection Imported from Guinea

Kang YJ, Shim MJ, Kim JY, Ji SY, Lee WJ, Yang J

  • Lab Med Online.
  • 2015 Jan;5(1):33-37.
  • doi: 10.3343/lmo.2015.5.1.33
Recently, the number of Korean travelers and workers to malaria-endemic regions has increased, and the number of patients with imported malaria cases has increased as well. In Korea, most cases...
Comparison of the Clinical Performance of Binax NOW RSV Versus Multiplex RT-PCR for Detection of Respiratory Syncytial Virus

Son JA, Kim SH, Shin JH, Jeon GW, Sin JB, Lee JY, Kim HR, Jun KR, Lee JN, Song SA

  • Lab Med Online.
  • 2015 Jan;5(1):27-32.
  • doi: 10.3343/lmo.2015.5.1.27
BACKGROUND: Respiratory syncytial virus (RSV) is one of the most important causes of lower respiratory tract infection. The rapid antigen test is a simple, cheap, and quick method for RSV...
Evaluation of CD3+CD4-CD8- (Double-negative) T Cells in Bronchoalveolar Lavage Fluid: an Effective Tool for Pulmonary Disease Diagnosis

Jang HB, Lee AJ, Kim MJ, Jeon CH, Suh HS, Hyun DS, Kim SG

  • Lab Med Online.
  • 2015 Jan;5(1):20-26.
  • doi: 10.3343/lmo.2015.5.1.20
BACKGROUND: Cellular analysis of bronchoalveolar lavage fluid (BALF) is a useful diagnostic tool for interstitial lung diseases (ILDs). The lymphocytes in BALF consist of CD3+CD4+ T cells (T4), CD3+CD8+ T...
Optimum Conditions for the Preparation of Red Blood Cell Suspensions for ABO Antibody Titration

Kang SJ, Cho SR, Lim YA

  • Lab Med Online.
  • 2015 Jan;5(1):15-19.
  • doi: 10.3343/lmo.2015.5.1.15
BACKGROUND: There is significant inter-laboratory variation in the ABO antibody (Ab) titer levels of blood samples because a standardized method has not yet been developed. The aim of this study...
Performance Evaluation of Glucometer Barozen H Based on ISO 15197 Standards

Kim YB, Seo JY, Lee SY, Park HD

  • Lab Med Online.
  • 2015 Jan;5(1):6-14.
  • doi: 10.3343/lmo.2015.5.1.6
BACKGROUND: We have evaluated the analytical performance of Barozen H (i-SENS Inc. Seoul, Korea), which was developed for glucose testing and can be connected to hospital information network systems. METHODS: We...
Frequency and Clinicohematologic Characteristics of MPL W515 Mutations in Patients with Myeloproliferative Neoplasms

Park SG, Kim KB, Lee W, Ha JS, Ryoo NH, Jeon DS, Kim JR, Ham JY, Suh JS, Kim YK

  • Lab Med Online.
  • 2015 Jan;5(1):1-1.
  • doi: 10.3343/lmo.2015.5.1.1
BACKGROUND: Recently, myeloproliferative leukemia (MPL) W515 mutations have been reported to be molecular markers for myeloproliferative neoplasms (MPNs). We studied the association between MPL W515 mutations and the clinico-hematological features...

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