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Four amino acids as serum biomarkers for anti-asthma effects in the ovalbumin-induced asthma mouse model treated with extract of Asparagus cochinchinensis

Choi JY, Kim SH, Kim JE, Park JW, Kang MJ, Choi HJ, Bae SJ, Lee JH, Jung YS, Hwang DY

  • Lab Anim Res.
  • 2019 Dec;35(4):238-247.
  • doi: 10.1186/s42826-019-0033-x
The butanol extract of Asparagus cochinchinensis roots fermented with Weissella cibaria (BAW) effectively prevents inflammation and remodeling of airway in the ovalbumin (OVA)-induced asthma model. To characterize biomarkers that can...
Chronic oral administration of Passiflora incarnata extract has no abnormal effects on metabolic and behavioral parameters in mice, except to induce sleep

Kim GH, Yi SS

  • Lab Anim Res.
  • 2019 Dec;35(4):230-237.
  • doi: 10.1186/s42826-019-0034-9
Although the number of prescriptions and dependence on sleeping pills are increasing, the associations with unexpected abnormal behaviors and metabolic diseases caused by the overuse of sleeping pills are not...
Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad

Kang JH, Jang YS, Lee HJ, Lee CY, Shin DY, Oh SH

  • Lab Anim Res.
  • 2019 Dec;35(4):221-229.
  • doi: 10.1186/s42826-019-0030-0
Signal transducer and activator of transcription 3 (STAT3) modulates a variety of genes involved in the regulation of critical functions, including cell proliferation, differentiation, apoptosis, angiogenesis, metastasis, and immunity. For...
Investigation of the effect of coffee on body weight, serum glucose, uric acid and lipid profile levels in male albino Wistar rats feeding on high-fructose diet

Feyisa TO, Melka DS, Menon M, Labisso WL, Habte ML

  • Lab Anim Res.
  • 2019 Dec;35(4):213-220.
  • doi: 10.1186/s42826-019-0024-y
Coffee is one of the most commonly consumed beverages in the worldwide and is assumed to have protective effects against metabolic syndrome. The present study was aimed at investigating the...
An improvement in acute wound healing in rats by the synergistic effect of photobiomodulation and arginine

Mostafavinia A, Bidram M, Avili AG, Mahmanzar , Karimifard SA, Sajadi E, Amini A, Hadipour Jahromy M, Ghoreishi , Chien S, Bayat M

  • Lab Anim Res.
  • 2019 Dec;35(4):202-212.
  • doi: 10.1186/s42826-019-0025-x
In this probe, at first we examined the best route and dosage of arginine administration on wound healing in an excisional wound model in rats. Next, we intend to assess...
Antitumor effect of TW-37, a BH3 mimetic in human oral cancer

Ahn CH, Lee WW, Jung YC, Shin JA, Hong KO, Choi S, Swarup N, Kim J, Ahn MH, Jung M, Cho SD, Jin B

  • Lab Anim Res.
  • 2019 Dec;35(4):194-201.
  • doi: 10.1186/s42826-019-0028-7
TW-37 is a small molecule B cell lymphoma-2 (Bcl-2) homology 3 mimetic with potential anticancer activities. However, the in vivo anti-cancer effect of TW-37 in human oral cancer has not...
Implication of Porphyromonas gingivalis in colitis and homeostasis of intestinal epithelium

Seo Y, Oh SJ, Ahn JS, Shin YY, Yang JW, Kim HS

  • Lab Anim Res.
  • 2019 Dec;35(4):187-193.
  • doi: 10.1186/s42826-019-0029-6
Emerging evidences have reported that periodontitis can be a risk factor for the pathogenesis of various systemic diseases. Porphyromonas gingivalis (Pg), one of the crucial pathogens in chronic periodontitis, has...
Verification with the utility of an established rapid assessment of brain safety for newly developed vaccines

Kim GH, Yi SS

  • Lab Anim Res.
  • 2019 Dec;35(4):180-186.
  • doi: 10.1186/s42826-019-0027-8
In the twenty-first century, high contagious infectious diseases such as SARS (Severe Acute Respiratory Syndrome), MERS (Middle East Respiratory Syndrome), FMD (Foot-and-Mouth Disease) and AI (Avian Influenza) have become very...
Identification of proteins differentially expressed by glutamate treatment in cerebral cortex of neonatal rats

Kang JB, Park DJ, Koh PO

  • Lab Anim Res.
  • 2019 Dec;35(4):172-179.
  • doi: 10.1186/s42826-019-0026-9
Glutamate leads to neuronal cell damage by generating neurotoxicity during brain development. The objective of this study is to identify proteins that differently expressed by glutamate treatment in neonatal cerebral...
TarGo: network based target gene selection system for human disease related mouse models

Hyung D, Mallon AM, Kyung DS, Cho SY, Seong JK

  • Lab Anim Res.
  • 2019 Dec;35(4):165-171.
  • doi: 10.1186/s42826-019-0023-z
Genetically engineered mouse models are used in high-throughput phenotyping screens to understand genotype-phenotype associations and their relevance to human diseases. However, not all mutant mouse lines with detectable phenotypes are...
Heat shock protein 70 increases cell proliferation, neuroblast differentiation, and the phosphorylation of CREB in the hippocampus

Kwon HJ, Kim W, Jung HY, Kang MS, Kim JW, Hahn KR, Yoo DY, Yoon YS, Hwang IK, Kim DW

  • Lab Anim Res.
  • 2019 Dec;35(4):154-164.
  • doi: 10.1186/s42826-019-0020-2
In the present study, we investigated the effects of heat shock protein 70 (HSP70) on novel object recognition, cell proliferation, and neuroblast differentiation in the hippocampus. To facilitate penetration into...
Involvement of immune responses in pulmonary arterial hypertension; lessons from rodent models

Kim K, Choi JH

  • Lab Anim Res.
  • 2019 Dec;35(4):148-153.
  • doi: 10.1186/s42826-019-0021-1
Pulmonary hypertension (PH) is a pathological state with sustained elevation of pulmonary artery (PA) pressure. Since the pathogenesis of PH is mostly irreversible, the disease often comes up with poor...

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