Skip Navigation
Skip to contents



25 results

Withdrawal: Protective effects of cultured and fermented ginseng extracts against scopolamine-induced memory loss in a mouse model

Han SH, Kim SJ, Yun YW, Nam SY, Lee HJ, Lee BJ

  • Lab Anim Res.
  • 2018 Dec;34(4):329-329.
  • doi: 10.5625/lar.2018.34.4.329
The reason why the author withdraw the paper is a controversy on intellectual property rights between JIBiopharm Inc. and Hoseo University.
Comparison of scopolamine-induced cognitive impairment responses in three different ICR stocks

Yoon WB, Choi HJ, Kim JE, Park JW, Kang MJ, Bae SJ, Lee YJ, Choi YS, Kim KS, Jung YS, Cho JY, Hwang DY, Song HK

  • Lab Anim Res.
  • 2018 Dec;34(4):317-328.
  • doi: 10.5625/lar.2018.34.4.317
Cognitive impairment responses are important research topics in the study of degenerative brain diseases as well as in understanding of human mental activities. To compare response to scopolamine (SPL)-induced cognitive...
Genetic and morphometric characteristics of Korean wild mice (KWM/Hym) captured at Chuncheon, South Korea

Nam H, Kim YY, Kim B, Yoon WK, Kim HC, Suh JG

  • Lab Anim Res.
  • 2018 Dec;34(4):311-316.
  • doi: 10.5625/lar.2018.34.4.311
Laboratory inbred mice are used widely and commonly in biomedical research, but inbred mice do not have a big enough gene pool for the research. In this study, genetic and...
CRISPR/Cas9-mediated knockout of CD47 causes hemolytic anemia with splenomegaly in C57BL/6 mice

Kim JI, Park JS, Kwak J, Lim HJ, Ryu SK, Kwon E, Han KM, Nam KT, Lee HW, Kang BC

  • Lab Anim Res.
  • 2018 Dec;34(4):302-310.
  • doi: 10.5625/lar.2018.34.4.302
CD47 (integrin-associated protein), a multi-spanning transmembrane protein expressed in all cells including red blood cells (RBCs) and leukocytes, interacts with signal regulatory protein α (SIRPα) on macrophages and thereby inhibits...
Nucleotide-binding oligomerization domain 1 is dispensable for host immune responses against pulmonary infection of Acinetobacter baumannii in mice

Kang MJ, Choi JA, Choi JH, Jang AR, Park JY, Ahn JH, Lee TS, Kim DY, Park JH

  • Lab Anim Res.
  • 2018 Dec;34(4):295-301.
  • doi: 10.5625/lar.2018.34.4.295
Nucleotide-binding domain 1 (Nod1) is a cytosolic receptor that is responsible for the recognition of a bacterial peptidoglycan motif containing meso-diaminophimelic acid. In this study, we sought to identify the...
Inhibition of endoplasmic reticulum stress in high-fat-diet-induced obese C57BL/6 mice: Efficacy of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris

Lee MR, Bae SJ, Kim JE, Song BR, Choi JY, Park JJ, Park JW, Kang MJ, Choi HJ, Choi YW, Kim KM, Hwang DY

  • Lab Anim Res.
  • 2018 Dec;34(4):288-294.
  • doi: 10.5625/lar.2018.34.4.288
A few clues about correlation between endoplasmic reticulum (ER) stress and mulberry (Morus alba) leaves were investigated in only the experimental autoimmune myocarditis and streptozotocin-induced diabetes. To investigate whether a...
CRISPR/Cas9-mediated generation of a Plac8 knockout mouse model

Lee H, Kim JI, Park JS, Roh JI, Lee J, Kang BC, Lee HW

  • Lab Anim Res.
  • 2018 Dec;34(4):279-287.
  • doi: 10.5625/lar.2018.34.4.279
Placenta specific 8 (PLAC8, also known as ONZIN) is a multi-functional protein that is highly expressed in the intestine, lung, spleen, and innate immune cells, and is involved in various...
Comparison of the anesthetic effects of 2,2,2-tribromoethanol on ICR mice derived from three different sources

Lee MR, Suh HR, Kim MW, Cho JY, Song HK, Jung YS, Hwang DY, Kim KS

  • Lab Anim Res.
  • 2018 Dec;34(4):270-278.
  • doi: 10.5625/lar.2018.34.4.270
This study was conducted to compare the anesthetic effects of 2,2,2-tribromoethanol (TBE, Avertin®) in ICR mice obtained from three different sources. TBE (2.5%) was intraperitoneally injected at three doses: high-dose...
Generation of knockout mouse models of cyclin-dependent kinase inhibitors by engineered nuclease-mediated genome editing

Park BM, Roh JI, Lee J, Lee HW

  • Lab Anim Res.
  • 2018 Dec;34(4):264-269.
  • doi: 10.5625/lar.2018.34.4.264
Cell cycle dysfunction can cause severe diseases, including neurodegenerative disease and cancer. Mutations in cyclin-dependent kinase inhibitors controlling the G1 phase of the cell cycle are prevalent in various cancers....
Disruption of the Tff1 gene in mice using CRISPR/Cas9 promotes body weight reduction and gastric tumorigenesis

Kim H, Jeong H, Cho Y, Lee J, Nam KT, Lee HW

  • Lab Anim Res.
  • 2018 Dec;34(4):257-263.
  • doi: 10.5625/lar.2018.34.4.257
Trefoil factor 1 (TFF1, also known as pS2) is strongly expressed in the gastrointestinal mucosa and plays a critical role in the differentiation of gastric glands. Since approximately 50% of...
[¹⁸F]FET PET is a useful tool for treatment evaluation and prognosis prediction of anti-angiogenic drug in an orthotopic glioblastoma mouse model

Kim OS, Park JW, Lee ES, Yoo RJ, Kim WI, Lee KC, Shim JH, Chung HK

  • Lab Anim Res.
  • 2018 Dec;34(4):248-256.
  • doi: 10.5625/lar.2018.34.4.248
O-2-¹⁸F-fluoroethyl-l-tyrosine ([¹⁸F]FET) has been widely used for glioblastomas (GBM) in clinical practice, although evaluation of its applicability in non-clinical research is still lacking. The objective of this study was to...
Bacopa monnieri extract improves novel object recognition, cell proliferation, neuroblast differentiation, brain-derived neurotrophic factor, and phosphorylation of cAMP response element-binding protein in the dentate gyrus

Kwon HJ, Jung HY, Hahn KR, Kim W, Kim JW, Yoo DY, Yoon YS, Hwang IK, Kim DW

  • Lab Anim Res.
  • 2018 Dec;34(4):239-247.
  • doi: 10.5625/lar.2018.34.4.239
Bacopa monnieri is a medicinal plant with a long history of use in Ayurveda, especially in the treatment of poor memory and cognitive deficits. In the present study, we hypothesized...
A comparison of metabolomic changes in type-1 diabetic C57BL/6N mice originating from different sources

Lee S, Kwak JH, Kim SH, Yun J, Cho JY, Kim K, Hwang D, Jung YS

  • Lab Anim Res.
  • 2018 Dec;34(4):232-238.
  • doi: 10.5625/lar.2018.34.4.232
Animal models have been used to elucidate the pathophysiology of varying diseases and to provide insight into potential targets for therapeutic intervention. Although alternatives to animal testing have been proposed...
Regulation of gastrointestinal hormones during laxative activity of gallotannin-enriched extract isolated from Galla Rhois in loperamide-induced constipation of SD rats

Kim JE, Kang MJ, Choi JY, Park JJ, Lee MR, Song BR, Kim HR, Park JW, Choi HJ, Bae SJ, Hwang DY

  • Lab Anim Res.
  • 2018 Dec;34(4):223-231.
  • doi: 10.5625/lar.2018.34.4.223
Regulation of gastrointestinal hormones have been reported in animal models for constipation undergoing laxative therapy when administered herbal products. We undertook to investigate whether the laxative activity of gallotannin-enriched extracts...
In vitro and in vivo inhibition of Helicobacter pylori by Lactobacilllus paracasei HP7

Hong SS, Lee HA, Kim JY, Jeong JW, Shim JJ, Lee JL, Sim JH, Chung Y, Kim O

  • Lab Anim Res.
  • 2018 Dec;34(4):216-222.
  • doi: 10.5625/lar.2018.34.4.216
The efficacy of standard therapeutic strategies for Helicobacter pylori (H. pylori) infection is decreasing over time due to the emergence of drug-resistant strains. As an alternative, the present study investigated...
Induction of superovulation in mature mice and rats using serum of spayed female dogs

Nooranizadeh M, Mogheiseh , Kafi M, Sepehrimanesh M, Vaseghi H

  • Lab Anim Res.
  • 2018 Dec;34(4):211-215.
  • doi: 10.5625/lar.2018.34.4.211
The following experiments were designed to examine the effect of serum of spayed dogs on superovulation response in mice and rats. In Experiment 1, female mice at diestrus (n=30) were...
Repeated restraint stress promotes hippocampal neuronal cell ciliogenesis and proliferation in mice

Lee K, Ko HW

  • Lab Anim Res.
  • 2018 Dec;34(4):203-210.
  • doi: 10.5625/lar.2018.34.4.203
Stress severely disturbs physiological and mental homeostasis which includes adult neurogenesis in hippocampus. Neurogenesis in hippocampus is a key feature to adapt to environmental changes and highly regulated by multiple...
Hyperglycemia aggravates decrease in alpha-synuclein expression in a middle cerebral artery occlusion model

Kang JB, Kim DK, Park DJ, Shah MA, Kim MO, Jung EJ, Lee HS, Koh PO

  • Lab Anim Res.
  • 2018 Dec;34(4):195-202.
  • doi: 10.5625/lar.2018.34.4.195
Hyperglycemia is one of the major risk factors for stroke. Hyperglycemia can lead to a more extensive infarct volume, aggravate neuronal damage after cerebral ischemia. α-Synuclein is especially abundant in...
Growing pigs developed different types of diabetes induced by streptozotocin depending on their transcription factor 7-like 2 gene polymorphisms

Tu CF, Hsu CY, Lee MH, Jiang BH, Guo SF, Lin CC, Yang TS

  • Lab Anim Res.
  • 2018 Dec;34(4):185-194.
  • doi: 10.5625/lar.2018.34.4.185
The different polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene promote variances in diabetes susceptibility in humans. We investigated whether these genotypes also promote differences in diabetic susceptibility in...
Changes of myelin basic protein in the hippocampus of an animal model of type 2 diabetes

Nam SM, Kwon HJ, Kim W, Kim JW, Hahn KR, Jung HY, Kim DW, Yoo DY, Seong JK, Hwang IK, Yoon YS

  • Lab Anim Res.
  • 2018 Dec;34(4):176-184.
  • doi: 10.5625/lar.2018.34.4.176
In this study, we observed chronological changes in the immunoreactivity and expression level of myelin basic protein (MBP), one of the most abundant proteins in the central nervous system, in...

Go to Top

Copyright © 2020 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: