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Super pregnancy in a BALB/c mouse superovulated with PMSG

Vaseghi H, Mogheiseh , Sepehrimanesh M, Kafi M, Nooranizadeh MH

  • Lab Anim Res.
  • 2017 Sep;33(3):280-282.
  • doi: 10.5625/lar.2017.33.3.280
This paper reports a case of super pregnancy in a BALB/c mouse pregnant with 30 pups following induction of superovulation using a PMSG-hCG protocol. Superovulation was induced in 10 mice...
Lipolytic effect of novel extracts from mulberry (Morus alba) leaves fermented with Cordyceps militaris in the primary adipocytes derived from SD rats

Lee MR, Kim JE, Yun WB, Choi JY, Park JJ, Kim HR, Song BR, Choi YW, Kim KM, Hwang DY

  • Lab Anim Res.
  • 2017 Sep;33(3):270-279.
  • doi: 10.5625/lar.2017.33.3.270
Mulberry (Morus alba) leaves are known to have therapeutic effects on lipid metabolism including lipogenesis, lipolysis and hyperlipidemia. However, novel compounds with strong lipolytic ability among 27 extracts of the...
Dose-dependent effects of busulfan on dog testes in preparation for spermatogonial stem cell transplantation

Hur TY, Lee SH, Ock SA, Song H, Park HJ, Lee R, Sung SH, Jhun H, Lee WY

  • Lab Anim Res.
  • 2017 Sep;33(3):264-269.
  • doi: 10.5625/lar.2017.33.3.264
Successful male germ cell transplantation requires depletion of the host germ cells to allow efficient colonization of the donor spermatogonial stem cells. Although a sterilizing drug, busulfan, is commonly used...
In vivo validation of metastasis-regulating microRNA-766 in human triple-negative breast cancer cells

Oh K, Lee DS

  • Lab Anim Res.
  • 2017 Sep;33(3):256-263.
  • doi: 10.5625/lar.2017.33.3.256
Breast cancer is the second most common cancer and the most frequent cancer in women worldwide. Recent improvements in early detection and effective adjuvant chemotherapies have improved the survival of...
Safety of 8-weeks oral administration of Arctium lappa L.

Bok SH, Cho SS, Bae CS, Park DH, Park KM

  • Lab Anim Res.
  • 2017 Sep;33(3):251-255.
  • doi: 10.5625/lar.2017.33.3.251
Recently, worldwide dietary reference intakes have been considered an important guideline for public health. Some governments and the World Health Organization (WHO) provide guidelines concerning dietary intake. Although an ingredient...
Cerebral ischemic injury decreases α-synuclein expression in brain tissue and glutamate-exposed HT22 cells

Koh PO

  • Lab Anim Res.
  • 2017 Sep;33(3):244-250.
  • doi: 10.5625/lar.2017.33.3.244
α-Synuclein is abundantly expressed in neuronal tissue, plays an essential role in the pathogenesis of neurodegenerative disorders, and exerts a neuroprotective effect against oxidative stress. Cerebral ischemia causes severe neurological...
Age-dependent differences in myelin basic protein expression in the hippocampus of young, adult and aged gerbils

Ahn JH, Lee TK, Park JH, Cho JH, Kim IH, Lee JC, Hong S, Jeon YH, Kang IJ, Lee YJ, Won MH, Lee CH

  • Lab Anim Res.
  • 2017 Sep;33(3):237-243.
  • doi: 10.5625/lar.2017.33.3.237
Myelin degeneration is one of the characteristics of aging and degenerative diseases. This study investigated age-related alterations in expression of myelin basic protein (MBP) in the hippocampal subregions (dentate gyrus,...
Evaluation of in vitro and in vivo genotoxicity of Angelica acutiloba in a standard battery of assays

Yun JW, Kim YS, Kwon E, Kim SH, You JR, Kim HH, Che JH, Kang BC

  • Lab Anim Res.
  • 2017 Sep;33(3):231-236.
  • doi: 10.5625/lar.2017.33.3.231
Among three representative species of Angelica found in Asian countries, including Korea, China, and Japan, Angelica acutiloba (AA) has been used as traditional herbal medicine with antitumor, anti-inflammatory, anti-obesity, and...
Preclinical safety assessment of Angelica acutiloba using a 13-week repeated dose oral toxicity study in rats

Yun JW, Kwon E, Kim SH, You JR, Kim YS, Park IA, Kim HH, Che JH, Kang BC

  • Lab Anim Res.
  • 2017 Sep;33(3):223-230.
  • doi: 10.5625/lar.2017.33.3.223
Angelica acutiloba (AA), a Japanese species of Danggui, has been used worldwide as a traditional herbal medicine with several bioactivities including anti-diabetic, anti-allergic, anti-inflammatory, anti-tumor, and anti-obesity. However, there is...
Early changes in retinal structure and BMP2 expression in the retina and crystalline lens of streptozotocin-induced diabetic pigs

Jeong JS, Lee WK, Moon YS, Kim NR

  • Lab Anim Res.
  • 2017 Sep;33(3):216-222.
  • doi: 10.5625/lar.2017.33.3.216
PURPOSE: This study aims to evaluate early changes in retinal structure and BMP2 expression in the retina and crystalline lens by comparing streptozotocin-induced diabetic pigs and normal control group pigs. METHODS:...
Artemisia argyi attenuates airway inflammation in lipopolysaccharide induced acute lung injury model

Shin NR, Park SH, Ko JW, Ryu HW, Jeong SH, Kim JC, Shin DH, Lee HS, Shin IS

  • Lab Anim Res.
  • 2017 Sep;33(3):209-215.
  • doi: 10.5625/lar.2017.33.3.209
Artemisia argyi is used as a health supplement, tea, and food source in Korea. This study aimed to evaluate the effect of Artemisia argyi (AA) and its active compound, dehydromatricarin...
Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury

Park DJ, Kim MO, Koh PO

  • Lab Anim Res.
  • 2017 Sep;33(3):202-208.
  • doi: 10.5625/lar.2017.33.3.202
Ischemic stroke is one of the leading causes of adult disability and death. Hyperglycemia is associated with an increased risk of stroke and poor outcomes after brain injury. Dynamin-like protein...
Antibacterial activity of essential oil from lavender (Lavandula angustifolia) against pet turtle-borne pathogenic bacteria

Hossain S, Heo H, De Silva B, Wimalasena SHMP, Pathirana , Heo GJ

  • Lab Anim Res.
  • 2017 Sep;33(3):195-201.
  • doi: 10.5625/lar.2017.33.3.195
Pet turtles are well-known to harbor an array of bacterial pathogens which can cause zoonotic infections in humans as well as opportunistic infections in the turtles itself. Essential oils are...

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