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Comparison of therapeutic responses to an anticancer drug in three stocks of ICR mice derived from three different sources

Sung JE, Kim JE, Lee HA, Yun WB, Choi JY, Lee MR, Park JJ, Kim HR, Song BR, Jung YS, Kim KS, Hwang DY

  • Lab Anim Res.
  • 2017 Jun;33(2):187-194.
  • doi: 10.5625/lar.2017.33.2.187
Korl:ICR mice, established by the Korean National Institute of Food and Drug Safety Evaluation (NIFDS), are characterized based on their genetic variation, response to gastric injury, and response to constipation...
Comparative study of fertilization rates of C57BL/6NKorl and C57BL/6N mice obtained from two other sources

Yun WB, Kim HR, Kim JE, Choi JY, Lee MR, Park JJ, Song BR, Jung YS, Song HK, Cho JY, Kim KS, Hwang DY

  • Lab Anim Res.
  • 2017 Jun;33(2):179-186.
  • doi: 10.5625/lar.2017.33.2.179
C57BL/6N is the most widely used inbred mouse strain applied in a wide variety of research areas including cancer, cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and...
Annual tendency of research papers used ICR mice as experimental animals in biomedical research fields

Kim JE, Nam JH, Cho JY, Kim KS, Hwang DY

  • Lab Anim Res.
  • 2017 Jun;33(2):171-178.
  • doi: 10.5625/lar.2017.33.2.171
Institute of Cancer Research (ICR) mice have been widely used in various research fields including toxicology, oncology, pharmacology, and pharmaceutical product safety testing for decades. However, annual tendency of research...
Comparision of doxorubicin-induced cardiotoxicity in the ICR mice of different sources

Kim SH, Kim KJ, Kim JH, Kwak JH, Song H, Cho JY, Hwang DY, Kim KS, Jung YS

  • Lab Anim Res.
  • 2017 Jun;33(2):165-170.
  • doi: 10.5625/lar.2017.33.2.165
Doxorubicin is a widely used chemotherapeutic agents and is now part of standard therapeutic regimens for a variety of cancers (eg, hematopoietic malignancies and advanced solid tumors of the breast,...
Comparative study of fatty liver induced by methionine and choline-deficiency in C57BL/6N mice originating from three different sources

Kim SH, Lim Y, Park JB, Kwak JH, Kim KJ, Kim JH, Song H, Cho JY, Hwang DY, Kim KS, Jung YS

  • Lab Anim Res.
  • 2017 Jun;33(2):157-164.
  • doi: 10.5625/lar.2017.33.2.157
Non-alcoholic fatty liver disease (NAFLD) is believed to be the most prevalent liver disease worldwide and a major cause of chronic liver injury. It is characterized by lipid accumulation in...
Comparison of the response using ICR mice derived from three different sources to multiple low-dose streptozotocin-induced diabetes mellitus

Lee DY, Kim MH, Suh HR, Jung YS, Hwang DY, Kim KS

  • Lab Anim Res.
  • 2017 Jun;33(2):150-156.
  • doi: 10.5625/lar.2017.33.2.150
This study was conducted to compare the multiple low-dose streptozotocin (MLDS)-induced diabetic patterns of Korl:ICR, A:ICR, and B:ICR mice obtained from three different sources. Six-week-old male ICR mice were obtained...
Comparative analysis of basal locomotor activity-related metabolic phenotypes between C57BL/6 mice and ICR mice substrains derived from three different sources

Hwang DJ, Song HK, Kim KS, Jung YS, Hwang DY, Cho JY

  • Lab Anim Res.
  • 2017 Jun;33(2):140-149.
  • doi: 10.5625/lar.2017.33.2.140
Animal model, as an indispensable tool for scientific purposes of biomedical researches and clinical application, is a commonly used in various researches. Regarding to this, it is necessary to establish...
Comparison of humoral and cell-mediated immunity in three different C57BL/6N mouse substrains

Kim HR, Choi JY, Kim KS, Jung YS, Cho JY, Hwang DY, Song HK

  • Lab Anim Res.
  • 2017 Jun;33(2):132-139.
  • doi: 10.5625/lar.2017.33.2.132
Adaptive immunity is a type of immune response mediated by T and B cells, and is important response for immune response amplification and memory. In this study, the adaptive immunologic...
Comparative study of the immunological characteristics of three different C57BL/6N mouse substrains

Choi JY, Kim HR, Kim KS, Jung YS, Cho JY, Hwang DY, Song HK

  • Lab Anim Res.
  • 2017 Jun;33(2):124-131.
  • doi: 10.5625/lar.2017.33.2.124
Inbred mice, a systematically developed homogeneous animal, have been developed to maintain experimental reproducibility and to minimize experimental variables in animal-based studies. In particular, C57BL/6 mice are frequently used in...
Use of C57BL/6N mice on the variety of immunological researches

Song HK, Hwang DY

  • Lab Anim Res.
  • 2017 Jun;33(2):119-123.
  • doi: 10.5625/lar.2017.33.2.119
Inbred mice are an essential animal strain for research as they can improve the reproducibility and reliability of study results. The establishment of new inbred lines is continuing, and new...
Immunohistochemical localization of glucose transporter 1 and 3 in the scrotal and abdominal testes of a dog

Hahn KR, Jung HY, Yoo DY, Kim JW, Kim YH, Jo YK, Kim GA, Chung JY, Choi JH, Hwang IK, Jang G, Yoon YS

  • Lab Anim Res.
  • 2017 Jun;33(2):114-118.
  • doi: 10.5625/lar.2017.33.2.114
Glucose is essential for testicular function; the uptake of carbohydrate-derived glucose by cells is mediated by glucose transporters (GLUTs). In the present study, we investigated the activity of GLUT1 and...
Blood flow-improving activity of methyl jasmonate-treated adventitious roots of mountain ginseng

Ban YH, Cha Y, Choi J, An ES, Lee JY, Han NR, Seo DW, Jung G, Jeong DH, Rhee MH, Choi EK, Kim YB

  • Lab Anim Res.
  • 2017 Jun;33(2):105-113.
  • doi: 10.5625/lar.2017.33.2.105
Ginsenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, blood flow-improving effects of...
Hyperglycemia decreases preoxiredoxin-2 expression in a middle cerebral artery occlusion model

Koh PO

  • Lab Anim Res.
  • 2017 Jun;33(2):98-104.
  • doi: 10.5625/lar.2017.33.2.98
Diabetes is a major risk factor for stroke and is also associated with worsened outcomes following a stroke. Peroxiredoxin-2 exerts potent neuroprotective effects against oxidative stress. In the present study,...
Effect of ionizing radiation at low dose on transgenerational carcinogenesis by epigenetic regulation

Li L, Kim JH, Park HT, Lee JH, Park MK, Lee JW, Lee JC, Lee MJ

  • Lab Anim Res.
  • 2017 Jun;33(2):92-97.
  • doi: 10.5625/lar.2017.33.2.92
The objective of this study was to determine the effect of ionizing radiation (IR) exposure of parents on carcinogenesis of the next generation focusing on the epigenetic perspective to clarify...
Antimicrobial property of lemongrass (Cymbopogon citratus) oil against pathogenic bacteria isolated from pet turtles

De Silva B, Jung WG, Hossain S, Wimalasena S, Pathirana , Heo GJ

  • Lab Anim Res.
  • 2017 Jun;33(2):84-91.
  • doi: 10.5625/lar.2017.33.2.84
The usage of essential oils as antimicrobial agents is gaining attention. Besides, pet turtles were known to harbor a range of pathogenic bacteria while the turtle keeping is a growing...
Pine bark extract (Pycnogenol®) suppresses cigarette smoke-induced fibrotic response via transforming growth factor-β1/Smad family member 2/3 signaling

Ko JW, Shin NR, Park SH, Kim JS, Cho YK, Kim JC, Shin IS, Shin DH

  • Lab Anim Res.
  • 2017 Jun;33(2):76-83.
  • doi: 10.5625/lar.2017.33.2.76
Chronic obstructive pulmonary diseases (COPD) is an important disease featured as intense inflammation, protease imbalance, and air flow limitation and mainly induced by cigarette smoke (CS). In present study, we...
Reproductive performance of genetically engineered mice housed in different housing systems

Yadav S, Yadav I, Pratap K, Tiwari PK, Singh VP

  • Lab Anim Res.
  • 2017 Jun;33(2):68-75.
  • doi: 10.5625/lar.2017.33.2.68
The genetically engineered mice require special husbandry care and are mainly housed in Individually Ventilated Cage (IVC) systems and Static Micro Isolator Cages (SMIC) to minimize the risk for spreading...
Hepatotoxicity and nephrotoxicity of saponin-enriched extract of Asparagus cochinchinensis in ICR mice

Sung JE, Choi JY, Kim JE, Lee HA, Yun WB, Park JJ, Kim HR, Song BR, Kim DS, Lee CY, Lee HS, Lim Y, Hwang DY

  • Lab Anim Res.
  • 2017 Jun;33(2):57-67.
  • doi: 10.5625/lar.2017.33.2.57
The inhibitory effects of Asparagus cochinchinensis against inflammatory response induced by lipopolysaccharide (LPS), substance P and phthalic anhydride (PA) treatment were recently reported for some cell lines and animal models....
Quinolone susceptibility and genetic characterization of Salmonella enterica subsp. enterica isolated from pet turtles

De Silva B, Hossain S, Wimalasena SHMP, Pathirana , Wendt M, Heo GJ

  • Lab Anim Res.
  • 2017 Jun;33(2):49-56.
  • doi: 10.5625/lar.2017.33.2.49
Turtle-borne Salmonella enterica owns significance as a leading cause in human salmonellosis. The current study aimed to determine the quinolone susceptibility and the genetic characteristics of 21 strains of S....

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