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12 results

Clinical and magnetic resonance imaging features of compressive cervical myelopathy with traumatic intervertebral disc herniation in cynomolgus macaque (Macaca fascicularis)

Choi YJ, Park HJ, Sohn CH, Jung KC, Park SH, Lee JI

  • Lab Anim Res.
  • 2016 Dec;32(4):267-271.
  • doi: 10.5625/lar.2016.32.4.267
Intervertebral disc herniation (IVDH) with nucleus pulposus extrusion, traumatic or not, is a devastating clinical condition accompanied by neurological problems. Here we report a cynomolgus macaque suffering from acute and...
Establishment of a surgically induced cryptorchidism canine recipient model for spermatogonial stem cell transplantation

Lee WY, Lee R, Song H, Hur TY, Lee S, Ahn J, Jhun H

  • Lab Anim Res.
  • 2016 Dec;32(4):257-266.
  • doi: 10.5625/lar.2016.32.4.257
Transplantation of spermatogonial stem cells (SSCs) in experimental animal models has been used to study germ line stem cell biology and to produce transgenic animals. The species-specific recipient model preparation...
Overexpression of N141I PS2 increases γ-secretase activity through up-regulation of Presenilin and Pen-2 in brain mitochondria of NSE/hPS2m transgenic mice

Yun WB, Park JJ, Kim JE, Sung JE, Lee HA, Lee JH, Bae CJ, Hwang DY

  • Lab Anim Res.
  • 2016 Dec;32(4):249-256.
  • doi: 10.5625/lar.2016.32.4.249
Alzheimer's disease (AD) is known to induce alterations of mitochondrial function such as elevation of oxidative stress and activation of apopotosis. The aim of this study was to investigate the...
Changes of hematological references depends on storage period and temperature conditions in rats and dogs

Lee JM, Kang JS

  • Lab Anim Res.
  • 2016 Dec;32(4):241-248.
  • doi: 10.5625/lar.2016.32.4.241
Because changes in rat and dog hematological parameters according to storage conditions have been poorly documented, we sought to examine such changes. Blood analysis was performed using two hematology analyzers...
Characterization the response of Korl:ICR mice to loperamide induced constipation

Kim JE, Yun WB, Sung JE, Lee HA, Choi JY, Choi YS, Jung YS, Kim KS, Hwang DY

  • Lab Anim Res.
  • 2016 Dec;32(4):231-240.
  • doi: 10.5625/lar.2016.32.4.231
Animal models of constipation induced with drugs and diet have been widely employed to investigate therapeutic effects and the action mechanism of drugs against this disease. ICR mice were selected...
Sirtuin-2 inhibition affects hippocampal functions and sodium butyrate ameliorates the reduction in novel object memory, cell proliferation, and neuroblast differentiation

Jung HY, Yoo DY, Kim JW, Kim DW, Choi JH, Chung JY, Won MH, Yoon YS, Hwang IK

  • Lab Anim Res.
  • 2016 Dec;32(4):224-230.
  • doi: 10.5625/lar.2016.32.4.224
We investigated the effects of the sirtuin-2 (SIRT2) inhibitor AK-7 on novel object memory, cell proliferation, and neuroblast differentiation in the dentate gyrus. In addition, we also observed the relationships...
Antioxidant and hepatoprotective effects of fermented red ginseng against high fat diet-induced hyperlipidemia in rats

Kim MH, Lee EJ, Cheon JM, Nam KJ, Oh TH, Kim KS

  • Lab Anim Res.
  • 2016 Dec;32(4):217-223.
  • doi: 10.5625/lar.2016.32.4.217
This study was performed to investigate the antioxidant and hepatoprotective effects of fermented red ginseng (Panax ginseng C.A. Meyer; FRG) on high-fat diet-induced hyperlipidemia in rats. Sprague-Dawley rats were divided...
Multilocus sequence typing analysis of Pseudomonas aeruginosa isolated from pet Chinese stripe-necked turtles (Ocadia sinensis)

Wendt M, Heo GJ

  • Lab Anim Res.
  • 2016 Dec;32(4):208-216.
  • doi: 10.5625/lar.2016.32.4.208
Our research sought to characterize the phylogeny of Pseudomonas aeruginosa isolated from pet Chinese stripe-necked turtles (Ocadia sinensis) to better understand its evolutionary relation to other isolates and increase understanding...
Diallyl disulfide attenuates acetaminophen-induced renal injury in rats

Shin JY, Han JH, Ko JW, Park SH, Shin NR, Jung TY, Kim HA, Kim SH, Shin IS, Kim JC

  • Lab Anim Res.
  • 2016 Dec;32(4):200-207.
  • doi: 10.5625/lar.2016.32.4.200
This study investigated the protective effects of diallyl disulfide (DADS) against acetaminophen (AAP)-induced acute renal injury in male rats. We also investigated the effects of DADS on kidney injury molecule-1...
Ischemic brain injury decreases dynamin-like protein 1 expression in a middle cerebral artery occlusion animal model and glutamate-exposed HT22 cells

Jang AR, Koh PO

  • Lab Anim Res.
  • 2016 Dec;32(4):194-199.
  • doi: 10.5625/lar.2016.32.4.194
Dynamin-like protein I (DLP-1) is an important mitochondrial fission and fusion protein that is associated with apoptotic cell death in neurodegenerative diseases. In this study, we investigated DLP-1 expression in...
Retrospective growth kinetics and radiosensitivity analysis of various human xenograft models

Lee JY, Kim MS, Kim EH, Chung N, Jeong YK

  • Lab Anim Res.
  • 2016 Dec;32(4):187-193.
  • doi: 10.5625/lar.2016.32.4.187
The purpose of this study was to delineate the various factors that affect the growth characteristics of human cancer xenografts in nude mice and to reveal the relationship between the...
Evaluation of stability and biocompatibility of PHEMA-PMMA keratoprosthesis by penetrating keratoplasty in rabbits

Hwang Y, Kim G

  • Lab Anim Res.
  • 2016 Dec;32(4):181-186.
  • doi: 10.5625/lar.2016.32.4.181
Artificial corneas have been developed as an alternative to natural donor tissue to replace damaged or diseased corneas. This study was conducted to evaluate the stability and biocompatibility of PHEMA-PMMA...

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