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9 results

Establishment of a murine model for radiation-induced bone loss using micro-computed tomography in adult C3H/HeN mice

Lee JH, Lee HJ, Yang M, Moon C, Kim JC, Jo SK, Jang JS, Kim SH

  • Lab Anim Res.
  • 2013 Mar;29(1):55-62.
Bone changes are common sequela of radiation therapy for cancer. The purpose of this study was to establish an experimental model of radiation-induced bone loss in adult mice using micro-computed...
4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats

Yu WJ, Lee IC, Lee J, Lee SM, Kim SH, Baek HS, Moon C, Kim SH, Chung YH, Kim JC

  • Lab Anim Res.
  • 2013 Mar;29(1):48-54.
The present study investigated the potential subacute toxicity of 1,4-dichlorobutane by a 4-week repeated oral dose in Sprague-Dawley rats. The test article was administered once daily by gavage to male...
Effects of dietary high fat on prostate intraepithelial neoplasia in TRAMP mice

Park SH, Chang SN, Baek MW, Kim DJ, Na YR, Seok SH, Lee BH, Kim KS, Park JH

  • Lab Anim Res.
  • 2013 Mar;29(1):39-47.
Increased fat intake is known to be a major cause of prostate cancer. In this study, we investigated the effect of dietary high fat on prostate intraepithelial neoplasia using transgenic...
A high resolution genetic mapping of the faded (fe) gene to a region between D10mit156 and D10mit193 on mouse chromosome 10

Oh SH, Nam H, Suh JG

  • Lab Anim Res.
  • 2013 Mar;29(1):33-38.
The C57BL/6J-fe/fe mouse is a coat color mutant. The coat color of the homozygote mouse becomes progressively lighter with advancing age. The faded gene (fe) of C57BL/6J-fe/fe was mapped in...
Usefulness of a Helicobacter pylori stool antigen test for diagnosing H. pylori infected C57BL/6 mice

Moon DI, Shin EH, Oh HG, Oh JS, Hong S, Chung Y, Kim O

  • Lab Anim Res.
  • 2013 Mar;29(1):27-32.
Among several diagnostic tests, a Helicobacter pylori stool antigen (HpSA) test may offer a useful noninvasive method for diagnosing infection without sacrificing animals. In this study, male C57BL/6 mice (n=6)...
Age-associated changes in pancreatic exocrine secretion of the isolated perfused rat pancreas

Jiang ZE, Jiang C, Chen B, Koh CS, Yong JH, Park DH, Won MH, Lee YL

  • Lab Anim Res.
  • 2013 Mar;29(1):19-26.
Gut functions, such as gastrointestinal motility, gastric secretion and pancreatic secretion, were reduced with age. Glucose tolerance is impaired, and the release of insulin and beta-cell's sensitivity on glucose are...
Stereological study of the diabetic heart of male rats

Noorafshan A, Khazraei H, Mirkhani H, Karbalay-Doust S

  • Lab Anim Res.
  • 2013 Mar;29(1):12-18.
The present study aimed to quantitatively compare the normal and diabetic hearts of rats using stereological methods. Diabetic and control rats received streptozotocin (60 mg/kg) and no treatments, respectively. On...
Specific nephrotoxicity and cardiotoxicity of BT-CAL(R), Sigma Anti-bonding Molecule Calcium Carbonate, in mice

Jang JY, Cai J, Kim J, Kyung J, Kim D, Choi EK, Kim Y, Kim KS, Park D, Kang HG, Kim YB

  • Lab Anim Res.
  • 2013 Mar;29(1):7-11.
According to a high anti-osteoporotic efficacy of Sigma Anti-bonding Molecule Calcium Carbonate (SAC), repeated-dose toxicities of SAC were investigated to assess its feasibility as drug or functional food ingredient. Male...
Serum leptin concentrations, leptin mRNA expression, and food intake during the estrous cycle in rats

Fungfuang , Nakada T, Nakao N, Terada M, Yokosuka M, Gizurarson S, Hau J, Moon C, Saito TR

  • Lab Anim Res.
  • 2013 Mar;29(1):1-6.
The aim of this study was to investigate food intake, serum leptin levels, and leptin mRNA expression during the sexual cycle in rats. Female Wistar-Imamichi rats aged 8-10 weeks were...

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