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Esculetin inhibits N-methyl-D-aspartate neurotoxicity via glutathione preservation in primary cortical cultures

Lee CR, Shin EJ, Kim HC, Choi YS, Shin T, Wie MB

Recently, loss of endogenous glutathione during N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxic injury, and the resultant overproduction of reactive oxygen species (ROS) through an arachidonic acid cascade process in brain, have been...
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Sensitive and specific identification by polymerase chain reaction of Eimeria tenella and Eimeria maxima, important protozoan pathogens in laboratory avian facilities

Lee HA, Hong S, Chung Y, Kim O

Eimeria tenella and Eimeria maxima are important pathogens causing intracellular protozoa infections in laboratory avian animals and are known to affect experimental results obtained from contaminated animals. This study aimed...
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Spontaneous osteosarcoma of the femur in a non-obese diabetic mouse

Hong S, Lee HA, Choe O, Chung Y, Kim O

An abnormal swelling was identified in the distal portion of the right femur in a 1-year-old non-obese diabetic (NOD) mouse. Grossly, a large mass of the distal femur was observed...
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High glucose stimulates the expression of erythropoietin in rat glomerular epithelial cells

Lim SK, Park SH

It has been reported that the levels of erythropoietin are associated with diabetes mellitus. Glomerular epithelial cells, located in the renal cortex, play an important role in the regulation of...
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Single- and repeated-dose toxicities of aloe fermentation products in rats

Cho JH, Kim HK, Baik SO, Choi SY, Lee JY

In this study, aloe fermentation products were derived from mycelia from 3 mushrooms: Ganoderma lucidum (AG), Hericium erinaceum (AH), and Phellinus linteus (AP). Levels of aloin A and B increased...
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In vitro antioxidant properties of a ginseng intestinal metabolite IH-901

Lee NJ, Lee JW, Sung JH, Lee YJ, Kang JK

IH-901 (20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol or compound K) is a final intestinal bacterial metabolite of ginseng in humans. It has various pharmacologic effects such as antiaging, immunopotentiation, antistress, and antimetastatic activities. We analyzed...
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Inorganic lead (Pb)- and mercury (Hg)-induced neuronal cell death involves cytoskeletal reorganization

Choi WS, Kim SJ, Kim JS

Inorganic lead and mercury are widely spread xenobiotic neurotoxicants threatening public health. The exposure to inorganic lead and mercury results in adverse effects of poisoning including IQ deficit and peripheral...
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Identification of bacteria from the oral cavity and cloaca of snakes imported from Vietnam

Jho YS, Park DH, Lee JH, Cha SY, Han JS

Reptiles are used for various purposes these days, including public exhibits, medicinal applications, and as laboratory animals. As the international exchange of reptiles has gradually increased, more people have had...
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Chemical compound 31002 stimulates cardiomyogenic differentiation of embryonic stem cells

Kim EK, Son MY, Kang Y, Lee CH, Kim HR, Won Y, Yoon W, Kim HC, Nam KH

Embryonic stem cells (ESCs) are an emerging source for cell-based therapies aimed at repairing damaged organ tissues; however, the efficiency of directed differentiation is low and refinement of differentiation protocols...
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Kinetics of proinflammatory cytokines after intraperitoneal injection of tribromoethanol and a tribromoethanol/xylazine combination in ICR mice

Cho YJ, Lee YA, Lee JW, Kim JI, Han JS

Tribromoethanol (2,2,2-tribromoethanol, TBE) is a popular injectable anesthetic agent used in mice in Korea. Our goal was to assess the risks associated with side effects (lesions) in the abdominal cavity,...
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Differential effects of treadmill exercise on cyclooxygenase-2 in the rat hippocampus at early and chronic stages of diabetes

Nam SM, Yi SS, Yoo KY, Park OK, Yan B, Song W, Won MH, Yoon YS, Seong JK

Cyclooxygenase-2 (COX-2) is believed to be a multifunctional neural modulator that affects synaptic plasticity in the hippocampus. In the present study, we investigated the differential effects of treadmill exercise on...
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Microglia in the normally aged hippocampus

Choi JH, Won MH

The hippocampus plays important roles in the regulation and combination of short and long term memory and spatial navigation with other brain centers. Aging is accompanied by a functional decline...
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