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Antifibrotic activity a fermentation filtrate of Ganoderma lucidum

Kwon SC, Kim YB

The effects of a fermentation filtrate of Ganoderma lucidum (FGL) on carbon tetrachloride (CCl4)-induced hepatic fibrosis were investigated in rats. Male Sprague-Dawley rats were orally administered with FGL (20 or...
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Antioxidative and aldose reductase-inhibitory effects of a fermentation filtrate of Rubus coreanus

Kwon SC, Kim YB

Antioxidative and aldose reductase (AR)-inhibitory effects of a fermentation filtrate of Rubus coreanus (FRC) were investigated using corneal/retinal homogenate and lens cytosol, respectively. Rat corneal/retinal homogenate was treated with 50...
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Canine hemangiosarcoma in a female Jindo dog

Mun A, Lee EM, Kim AY, Lee EJ, Hong IH, Jeong KS

A fourteen-year female Jindo dog showing signs of hemoperitoneum was diagnosed with hemangiosarcoma through abdominal radiography and histopathological examination. In the abdominal radiographs, a circular mass was observed on the...
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Detection of sarcocystic infection in a wild rodent (Apodemus agrarius chejuensis) captured on Jeju island

Kim TH, Han JH, Chang SN, Kim DS, Abdelkader TS, Seok SH, Park JH, Oh HS, Kim JT, Lee BH, Shin JH, Kim JH, Kim JM, Park JH

Sarcocystis spp is a causative agent of sarcocystosis. They have a characteristic life cycle infecting both prey and predator. Sarcocystis can cause myositis, atrophy of the adjacent cells and abortion...
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Angiotropic metastatic malignant melanoma in a canine mammary gland

Yang HJ, Lee EM, Kim AY, Lee EJ, Hong IH, Huh SO, Jeong KS

An eleven-year-old spayed female Yorkshire Terrier presented with a sublumbar mass and upon ultrasonographic examination, was revealed to have a mammary gland tumor. Black to reddish colored masses, located in...
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Uterine adenocarcinoma with feline leukemia virus infection

Cho SJ, Lee HA, Hong S, Kim O

Feline endometrial adenocarcinomas are uncommon malignant neoplasms that have been poorly characterized to date. In this study, we describe a uterine adenocarcinoma in a Persian cat with feline leukemia virus...
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Shigella flexneri infection in a newly acquired rhesus macaque (Macaca mulatta)

Lee JI, Kim SJ, Park CG

A 3.4 year-old rhesus macaque weighing 4.5 kg, was suffering from anorexia, acute mucous and bloody diarrhea. On physical examination, the monkey showed a loss of activity, hunched posture, abdominal...
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Subcellular localization of the transmembrane inner ear (Tmie) protein in a stable Tmie-expressing cell line

Karuppasamy S, Nam YY, Jung H, Park B, Kwon HJ, Suh JG

Mutations in the transmembrane inner ear (Tmie) gene, which encodes the Tmie protein, have been attributed to deafness autosomal recessive 6 (DFNB6), an autosomal nonsyndromic recessive hearing loss disorder. Although...
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Inhibitor of DNA-binding 4 contributes to the maintenance and expansion of cancer stem cells in 4T1 mouse mammary cancer cell line

Park SJ, Kim RJ, Nam JS

The cancer stem cell (CSC) hypothesis proposes that CSCs are the root of cancer. CSC-targeted therapies may prevent cancer relapse and provide more effective treatment. The expression of aldehyde dehydrogenase...
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High glucose stimulates glutamate uptakes in pancreatic beta-cells

Han HJ, Park SH

Pancreatic beta-cells are major cells responsible for glucose metabolism in the body. Hyperglycemia is known to be a primary factor in the induction of diabetes mellitus. Glutamate is also an...
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Inhibitory effect of Suaeda asparagoides (Miq.) extract on the motility of rat gastric antrum is mediated by beta-adrenoceptor

Endale M, Song JC, Rhee MH, Liu KH, Kim TK, Kwon JG, Park KS, Chung KM, Kim TW

Suaeda asparagoides (Miq.) has long been used as a Korean folk herbal medicine for the treatment of functional gastrointestinal disorders. However, reports on its pharmacological activity on gastrointestinal motility are...
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Magnetic resonance imaging evaluation of Yukatan minipig brains for neurotherapy applications

Yun SP, Kim DH, Ryu JM, Park JH, Park SS, Jeon JH, Seo BN, Kim HJ, Park JG, Cho KO, Han HJ

Magnetic resonance imaging (MRI) of six Yukatan minipig brains was performed. The animals were placed in stereotaxic conditions currently used in experiments. To allow for correctpositioning of the animal in...
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Effects of Sigma Anti-bonding Molecule Calcium Carbonate on bone turnover and calcium balance in ovariectomized rats

Choi SY, Park D, Yang G, Lee SH, Bae DK, Hwang SY, Lee PK, Kim YB, Kim IH, Kang HG

This study was conducted to evaluate the effect of Sigma Anti-bonding Molecule Calcium Carbonate (SAC) as therapy for ovariectomy-induced osteoporosis in rats. Three weeks after surgery, fifteen ovariectomized Sprague-Dawley rats...
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Peroxiredoxin I regulates the component expression of gamma-secretase complex causing the Alzheimer's disease

Lee YJ, Goo JS, Kim JE, Nam SH, Hwang IS, Choi SI, Lee HR, Lee EP, Choi HW, Kim HS, Lee JH, Jung YJ, Kim HJ, Hwang DY

Peroxiredoxin I (Prx I) is a member of the peroxiredoxins (Prxs) family, which are antioxidant enzymes that regulate various cellular process via intracellular oxidative signal pathways. In order to investigate...
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Basic data on the hematology, serum biochemistry, urology, and organ weights of beagle dogs

Choi SY, Hwang JS, Kim IH, Hwang DY, Kang HG

This study was conducted to provide basic data on physiological and hematological characteristics, and organ weights of beagle dogs. A total of 237 beagle dogs were used to determine differences...
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Effects of Ficus carica paste on constipation induced by a high-protein feed and movement restriction in beagles

Oh HG, Lee HY, Seo MY, Kang YR, Kim JH, Park JW, Kim OJ, Back HI, Kim SY, Oh MR, Park SH, Kim MG, Jeon JY, Hwang MH, Shin SJ, Chae SW

Constipation is one of the most common functional digestive complaints worldwide. We investigated the laxative effects of figs (Ficus carica L) in a beagle model of constipation induced by high...
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Diverse animal models to examine potential role(s) and mechanism of endocrine disrupting chemicals on the tumor progression and prevention: Do they have tumorigenic or anti-tumorigenic property?

Park MA, Hwang KA, Choi KC

Acting as hormone mimics or antagonists in the interaction with hormone receptors, endocrine disrupting chemicals (EDCs) have the potentials of disturbing the endocrine system in sex steroid hormone-controlled organs and...
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