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Establishment of a Research and Assessment System Using High Quality Non-Human Primates

Hyun BH, Kang BC, Kim CK, Kim HS, Suh JG, Cho F

  • Lab Anim Res.
  • 2010 Dec;26(4):449-457.
  • doi: 10.5625/lar.2010.26.4.449
At present, eight non-human primate research facilities exist in Korea to examine the validity and safety of new bio-products, and to generate model animal systems using primates of low health...
Comparison on the Embryological Terms between the Korean Veterinary Anatomical Terminology (2008) and the Korean Anatomical Terminology (1996)/the Korean Medical Association: Medical Terminology (2009)

Kim DJ

  • Lab Anim Res.
  • 2010 Dec;26(4):439-447.
  • doi: 10.5625/lar.2010.26.4.439
Since the first edition of the Korean Veterinary Anatomical Terminology (KVAT) in 1993, the new edition of KVAT has been revised and harmonized with the recent version of the Korean-English...
The Need for the Introduction of Assessment Program of Good Animal Care and Use Facility

Lee SK, Cha SW

  • Lab Anim Res.
  • 2010 Dec;26(4):433-438.
  • doi: 10.5625/lar.2010.26.4.433
The humane care and use of animals should be the prime concern and responsibility of all those individuals using animals for research, teaching or testing. The use of animals as...
Rectal Prolapse Associated with Recurrent Diarrhea in a Laboratory Cynomolgus Monkey (Macaca fascicularis)

Lee SR, Lee YH, Kim KM, Kim SW, Jung KJ, Kim YH, Son HY, Chang KT

  • Lab Anim Res.
  • 2010 Dec;26(4):429-432.
  • doi: 10.5625/lar.2010.26.4.429
Rectal prolapse is a protrusion of one or more layers of the rectum through the anus. A 5-year-old laboratory cynomolgus monkey who had suffered from recurrent diarrhea died after surgical...
Laboratory Rodents Negatively Affected by Construction Environment

Lee BH, Jung HD, Lee BN, Park KS, Han JS

  • Lab Anim Res.
  • 2010 Dec;26(4):425-428.
  • doi: 10.5625/lar.2010.26.4.425
This report describes rodents in a laboratory animal facility that was adversely affected by a noisy environment during construction work. There was much noise and vibration as well as dust...
Establishment of Leukemia Mouse Model Using Mouse-Derived A20 Leukemic Cells, and Detection of Tumor Cells in Bone Marrow

Wen LY, Bae SM, Ahn WS

  • Lab Anim Res.
  • 2010 Dec;26(4):415-423.
  • doi: 10.5625/lar.2010.26.4.415
Objectives of this study were to establish a leukemia mouse model in the Balb/c mouse based upon the A20 cell line (murine B-lymphoma/leukemia cell line, H-2d). Here we demonstrate for...
Antioxidative and Antidiarrheal Effects of Persimmon Extracts

Park D, Lee SH, Bae DK, Cho YJ, Kim TK, Yang YH, Yang G, Kwon SC, Lee DI, Joo SS, Kim YB

  • Lab Anim Res.
  • 2010 Dec;26(4):407-413.
  • doi: 10.5625/lar.2010.26.4.407
Since oxidative stresses are involved in gastroenteritis and diarrhea, we investigated antioxidative and antidiarrheal activities of persimmon flesh extract (PFE) and persimmon calyx extract (PCE) in vitro and in vivo,...
Pharmacokinetic and Toxicokinetic Studies of Potential Antifungal Compounds, KAF-200522 and KAF-200522 . HCl, in Animal Models

Kong KH, Jung JY, Koo KH, Song SW, Kim KH, Han ZZ, Lee SH, Shin HC

  • Lab Anim Res.
  • 2010 Dec;26(4):399-405.
  • doi: 10.5625/lar.2010.26.4.399
Recent researches on clinically used triazole antifungal reagents are focused on their pharmacokinetic disadvantage which increases the probability of inducing adverse effects in patients. For this point, in the present...
An Improved Method for Intrathecal Catheterization in the Rat

Jeong YC, Kwon YB

  • Lab Anim Res.
  • 2010 Dec;26(4):393-397.
  • doi: 10.5625/lar.2010.26.4.393
Catheterization of the subarachnoid space provides a useful tool to deliver drugs to spinal cord in rat. However, the passage of a long intrathecal catheter inserted via the cisterna magnum...
Biological Activity and Single Oral Dose Toxicity of Dansam-samultang

Lee IC, Kim BH, Kim MK

  • Lab Anim Res.
  • 2010 Dec;26(4):385-391.
  • doi: 10.5625/lar.2010.26.4.385
In this study, we investigated the in vitro antioxidative effects, antimicrobial activities and single oral dose toxicity of the extracts from Dansam-samultang to evaluate its use as a functional ingredient...
The Symptoms of Atopic Dermatitis in NC/Nga Mice Were Significantly Relieved by the Water Extract of Liriope platyphylla

Kim JE, Lee YK, Nam SH, Choi SI, Goo JS, Jang MJ, Lee HS, Son HJ, Lee CY, Hwang DY

  • Lab Anim Res.
  • 2010 Dec;26(4):377-384.
  • doi: 10.5625/lar.2010.26.4.377
Atopic dermatitis is an well-known skin disease showing inflammatory, chronically relapsing, non-contagious and pruritic symptoms. The aims of this study were to investigate the effects of Liriope platyphylla (LP) on...
The Incidence Rate and Severity of Orthotopic Lung Cancer in an Animal Model Depends on the Number of A549 Cells and Transplantation Period

Lee J, Han YA, Yang HS, Song JA, Yang YS, Kwon S, Kang MS, Lee K, Heo JD, Cho KH, Song CW

  • Lab Anim Res.
  • 2010 Dec;26(4):369-375.
  • doi: 10.5625/lar.2010.26.4.369
The incidence rate of lung cancer is continually increasing, and lung cancer is the leading cause of cancer-related death worldwide. Nevertheless, few therapeutic methods are available for lung cancer. Therefore,...
Dangyuja (Citrus grandis Osbeck) Peel Improves Lipid Profiles and Alleviates Hypertension in Rats Fed a High-Fat Diet

Hong HJ, Jin JY, Yang H, Kang WY, Kim DG, Lee S, Choi Y, Kim JH, Han CH, Lee YJ

  • Lab Anim Res.
  • 2010 Dec;26(4):361-367.
  • doi: 10.5625/lar.2010.26.4.361
Obesity is a major public health problem and significant risk factor for many serious diseases including coronary artery disease, cancer, and diabetes. This study was performed to investigate the hypolipidemic...
Antifungal Effects of New Synthetic Materials, KAF-200522 and KAF-200522-HCl, on in vitro and in vivo Models

Jung JY, Kong KH, Koo KH, Song SW, Kim KH, Han ZZ, Lee YJ, Han JS

  • Lab Anim Res.
  • 2010 Dec;26(4):353-359.
  • doi: 10.5625/lar.2010.26.4.353
KAF-200522 and its chloride form, KAF-200522-HCl, were invented in Chemon inc. as new triazole antifungal agents with excellent activities in vivo and in vitro against wide range of fungi. As...
Experimental Models of Cerebral Palsy in Infant Rats

Park D, Kim TK, Choi YJ, Lee SH, Kang H, Yang YH, Bae DK, Yang G, Kim YB

  • Lab Anim Res.
  • 2010 Dec;26(4):345-351.
  • doi: 10.5625/lar.2010.26.4.345
Brain damage resulting from perinatal cerebral hypoxia and ischemia is a major cause of acute mortality and neurological disabilities, including cerebral palsy (CP) and cognitive dysfunction. In order to establish...
Modifying Effect of Indole-3-carbinol on the Rat Colon Carcinogenesis

Jo H, Han BS, Kang JS, Jang DD, Kim K, Ahn B, Kim DJ

  • Lab Anim Res.
  • 2010 Dec;26(4):339-343.
  • doi: 10.5625/lar.2010.26.4.339
Indole-3-carbinol (I3C) found in various cruciferous vegetables has been shown to exert anti-carcinogenic activity in several target organs. Our study was conducted to assess the modifying effect of I3C on...
Functional Analysis of TRPV6 Polymorphisms

Kim BJ, So I

  • Lab Anim Res.
  • 2010 Dec;26(4):331-337.
  • doi: 10.5625/lar.2010.26.4.331
The rate-limiting step of dietary calcium absorption in the intestine requires the brush border calcium entry channel transient receptor potential vanilloid 6 (TRPV6). The putatively-selected TRPV6 haplotype contains three candidate...
Gene Mutations in Animal Models: Do Tumor Suppressor Genes, brca1 and brca2, Play a Role in Ovarian Carcinogenesis?

Yi BR, Hwang KA, Choi KC

  • Lab Anim Res.
  • 2010 Dec;26(4):323-330.
  • doi: 10.5625/lar.2010.26.4.323
Ovarian cancer is the most lethal cause of death from gynecological malignancies in the Western world. Over 90% of human ovarian cancers arise in the ovarian surface epithelium (OSE). The...

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