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A Case of Parathyroid Carcinoma Presenting Hyperparathyroidism that was Clinically Easy to Overlook

Lee JH, Koo JW, Chin SO, Rhee SY, Choi MC, Chon S, Oh S, Woo JT, Kim SW, Kim JW, Kim YS

Parathyroid carcinoma is very rare in patients with primary hyperparathyroidism, only accounts for 1% to 2% of all cases. It is characterized by higher incidence of renal dysfunction, metabolic bone...
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New Avenues in the LRP5-mediated Bone Mass Acquisition

Choi JY

Lipoprotein receptor-related protein (LRP5) signaling is well correlated with the bone mass in both human and mice. Loss-of-function mutations of LRP5 result in osteopenia or osteoporosis. In contrast, gain-of-function mutations...
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A Case of Severe Hypercalcemia after Treatment with Teriparatide for Osteoporosis

Koo JW, Lee JH, Jang NE, Kim H, Seok HY, So YR, Shin AR, Cho JH, Lee SH

Recombinant human parathyroid hormone 1-34 (rHPTH; 1-34, teriparatide) increases bone mass and increases osteoporotic fracture by stimulating new bone formation. It was approved in the United States for treatment of...
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Routine Application of the Korean FRAX Model in Women: a Single-center Study

Kim TH, Lee HH, Chung SH, Lee WS, Park J, Lee S

OBJECTIVES: The objective of this study was to assess the efficacy of the Korean fracture-risk assessment tool (FRAX) model for routine application in women who had a general check-up for...
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Sequential Sacral Insufficiency Fracture After Unilateral Pubic Fractures: A Case Report

Park KS, Lee DH, Peni I, Yoon TR

Osteoporotic fractures of the pelvic ring are not uncommon and among them sacral insufficiency fractures (SIFs) are often overlooked in patients with buttock or low back pain following no or...
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Identification of Alternatively Spliced Forms of human OSCAR in Osteoclasts

Kim N, Park HY, Kim HD

OBJECTIVES: Osteoclasts are multinucleated giant cells which can resorb bone and differentiated from hematopoietic cells. We have previously reported murine osteoclast-associated receptor (OSCAR) may be an important bone-specific regulator of...
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The Effects of Extracellular pH on Proliferation and Differentiation of human Bone Marrow Stem Cells

Leem YH, Nam TS, Kim JH, Lee KS, Lee DH, Yun J, Chang JS

OBJECTIVES: The purpose of this study is to identify whether the change of pH affects the proliferation and the differentiation of human bone marrow stem cells (hBMSCs) and what mechanism...
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The Functional Analysis of MLKs-JNK Pathways in Osteoclast Formation

Ji SY, Ting Z, Noh AL, Moon M, Yim M

OBJECTIVES: Osteoclasts (OCs) are bone-resorbing multinucleated cells derived from hematopoietic progenitors of the monocyte-macrophage lineage. OC precursors, such as bone marrow-derived macrophages (BMMs), are formed in the presence of macrophage...
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