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Effects of Fluoxetine on Membrane Potential and Ionic Currents in RINm5F Insulinoma Cells

Park KC, Oh GT, Cha SK, Lee KI, Park KS, Jeong SW, Kong ID, Lee JW

  • KMID: 2286921
  • Korean J Psychopharmacol.
  • 2001 Sep;12(3):233-241.
OBJECTIVE: The purpose of this study was to investigate the effects of fluoxetine (Prozac) on membrane potential and ionic currents in RINm5F insulinoma cells. METHODS: Membrane potential and ionic currents...
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Identification of ATP-sensitive K+ Conductances in Male Rat Major Pelvic Ganglion Neurons

Park KS, Cha SK, Lee KI, Jun JY, Jeong SW, Kong ID, Lee JW

  • KMID: 2285259
  • Korean J Physiol Pharmacol.
  • 2002 Oct;6(5):247-254.
Major pelvic ganglia (MPG) neurons are classified into sympathetic and parasympathetic neurons according to the electrophysiological properties; membrane capacitance (Cm), expression of T-type Ca2+ channels, and the firing patterns during...
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Characteristics of Nicotinic Receptor Expressed in Human Retinoblastoma

Kim DR, Cha SK, Kong ID, Jung SH, Rah SH

  • KMID: 2126199
  • J Korean Ophthalmol Soc.
  • 2005 Jun;46(6):1060-1067.
PURPOSE: To identify the characteristics and physiological function of the nicotinic receptor expressed in human retinoblastoma cells. METHODS: We measured possible nicotinic signaling in WERI-Rb-1 cells using the Ca2+ imaging...
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Functional Expression of P2Y Receptors in WERI-Rb1 Retinoblastoma Cells

Kim NH, Park KS, Sohn JH, Yeh BI, Ko CM, Kong ID

  • KMID: 2389110
  • Korean J Physiol Pharmacol.
  • 2011 Feb;15(1):61-66.
P2Y receptors are metabotropic G-protein-coupled receptors, which are involved in many important biologic functions in the central nervous system including retina. Subtypes of P2Y receptors in retinal tissue vary according...
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Neuronal Excitatory Action of GABA on the Pelvic Ganglia

Gill SB, Cha SK, Kim DR, Jang SG, Jang YK, Kong ID

  • KMID: 1822221
  • J Korean Neurosurg Soc.
  • 2004 Aug;36(2):145-149.
OBJECTIVE: In the central nervous system, gamma-aminobutyric acid (GABA) is well known to act as an inhibitory neurotransmitter by hyperpolarizing postsynaptic neurons through gating GABA-activated Cl- channels. To date, however,...
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Identification of P2Y11 Receptor Expressed in Human Retinoblastoma Cells

Kim YH, Kim DR, Chun KI, Lee JH, Kong ID

  • KMID: 2337511
  • J Korean Ophthalmol Soc.
  • 2007 Aug;48(8):1134-1142.
PURPOSE: The present study aimed to identify the characteristics and physiological function of the P2Y11 receptor, a receptor likely expressed in human retinoblastoma cells. METHODS: We measured possible P2Y11 signaling in...
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The Understanding and Application of Telomere Length as an Emerging Biomarker in Adult Nursing Research: A Review

Han S, Min J, Kim DK, Kong ID, Kim N

Purpose This study aimed to provide an overview of telomere length (TL) as an emerging biomarker in adult healthcare. Additionally, some measurement considerations and future directions for its application in adult...
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Hemodynamic characteristics of extracellular UTP in the perfused rat liver

Kong ID, Chung HS, Park KS, Han JK, Lee JW

Uridine 5'-triphosphate (UTP) is stored in the granules of cells such as platelets and is released into the extracellular space upon cell stimulation. Extracellular UTP is known to influence many...
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Modulation of Inwardly Rectifying K+ Channel by Intracellular and Extracellular pH in Bovine Aortic Endothelial Cells

Park KS, Kong ID, Lee JW, Rhim HW, Kim YC, So IS, Kim KW

  • KMID: 2285260
  • Korean J Physiol Pharmacol.
  • 2002 Oct;6(5):255-260.
The effects of intracellular and extracellular pH on the inwardly rectifying K+ (IRK) channel of the bovine aortic endothelial cells (BAECs) were examined using whole-cell patch-clamp technique. The IRK current,...
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Multidimensional Biomarker Analysis Including Mitochondrial Stress Indicators for Nonalcoholic Fatty Liver Disease

Chang E, Chang JS, Kong ID, Baik SK, Kim MY, Park KS

Nonalcoholic fatty liver disease (NAFLD) is accompanied by a complex and multifactorial pathogenesis with sequential progressions from inflammation to fibrosis and then to cancer. This heterogeneity interferes with the development...
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Effects of Selective Serotonin Reuptake Inhibitors (SSRIs) on the Vasoconstriction of Isolated Rat Aorta

Park KS, Kong ID, Park KC, Lee JW

BACKGROUND: One of the most common side effects of antidepressant medication is orthostatic hypotension, which can be caused by impaired vasoconstriction. This study was designed to compare the inhibitory effects...
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Changes in Inward Rectifier K+ Channels in Hepatic Stellate Cells During Primary Culture

Lee DH, Kong ID, Lee JW, Park KS

PURPOSE: This study examined the expression and function of inward rectifier K+ channels in cultured rat hepatic stellate cells (HSC). MATERIALS AND METHODS: The expression of inward rectifier K+ channels...
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Effects of Adenosine 5'-Tetraphosphate on the Cardiac Activity*

Lee JW, Park KS, Kong ID

BACKGROUND: Adenosine 5'-tetraphosphate(ATPP), an endogenous nucleotide, is stored in cells and released into the extracellular space upon stimulation. Some of the biological responses to ATPP were reported, but characteristics of...
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Inwardly Rectifying K+ Currents in Gastric Myocytes of Guinea-pig

Jun JY, Yeum CH, Yoon PJ, Jang IY, Cho NS, Cho SH, Kong ID, Kim TW, So I, Kim KW

  • KMID: 1614860
  • Korean J Physiol Pharmacol.
  • 2002 Feb;6(1):47-56.
To identify the presence of inwardly rectifying K+ channels and its characteristics, membrane currents were measured using a whole-cell patch clamp from isolated gastric myocytes of guinea-pig. Change of external...
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Effects of adenosine tetraphosphate (ATPP) on vascular tone in the isolated rat aorta

Lee JW, Kong ID, Park KS, Jeong SW

Effects of a platelet-released, naturally occurring nucleotide, adenosine 5'-tetraphosphate (ATPP) on vascular tone were analyzed in the isolated rat aorta. Under resting tension ATPP (1 approximately 100 microM) elicited concentration-dependent...
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Effects of Haloperidol on [Ca2+]i Change in HIT T-15 Insulinoma Cells

Kim MH, Park KC, Jin SY, Kim DR, Kim MJ, Park KS, Kong ID

  • KMID: 2287031
  • Korean J Psychopharmacol.
  • 2007 Sep;18(5):288-298.
OBJECTIVE: The purpose of this study was to investigate the effects of haloperidol on [Ca2+]i in hamster insulinoma cells (HIT T-15). METHODS: [Ca2+]i levels were measured by calcium imaging techniques, and...
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Depression of L-type Ca2+ and transient outward K+ currents in endotoxin-treated rat cardiac myocytes

Park KS, Lee BS, Kong ID, Lee JW

  • KMID: 2071566
  • Korean J Physiol Pharmacol.
  • 1999 Dec;3(6):623-630.
Decreased cardiac contractility occurs in endotoxicosis, but little is known about the ionic mechanism responsible for myocardial dysfunction. In this study, we examined the changes in Ca2+ and K+ currents in cardiac myocytes...
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Effect of Regular Exercise on Cardiopulmonary Fitness in Males With Spinal Cord Injury

Lee YH, Oh KJ, Kong ID, Kim SH, Shinn JM, Kim JH, Yi D, Lee JH, Chang JS, Kim TH, Kim EJ

OBJECTIVE: To evaluate the cardiopulmonary endurance of subjects with spinal cord injury by measuring the maximal oxygen consumption with varying degrees of spinal cord injury level, age, and regular exercise. METHODS:...
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Klotho plays a critical role in clear cell renal cell carcinoma progression and clinical outcome

Kim JH, Hwang KH, Lkhagvadorj S, Jung JH, Chung HC, Park KS, Kong ID, Eom M, Cha SK

Klotho functions as a tumor suppressor predominantly expressed in renal tubular cells, the origin of clear cell renal cell carcinoma (ccRCC). Altered expression and/or activity of growth factor receptor have...
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Effect of Fluoxetine on Calcium or Potassium Channels in the Neuron of Rat Major Pelvic Ganglia

Lee KI, Song YS, Park YH, Cha SK, Kim DR, Park KS, Song ES, Kong ID

  • KMID: 2294078
  • Korean J Urol.
  • 2005 Jun;46(6):626-631.
PURPOSE: The major pelvic ganglia (MPG) provide the majority of the innervations to the lower urinary tract. The pelvic ganglia are unique autonomic ganglia that contain both sympathetic and parasympathetic...
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