- Quercetin attenuates the reduction of parvalbumin in middle cerebral artery occlusion animal model
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Park DJ, Kang JB, Shah FA, Koh PO
- KMID: 2514399
- Lab Anim Res.
- 2021 Mar;37(1):74-81.
- doi: 10.1186/s42826-021-00086-0
Background: Calcium is a critical factor involved in modulation of essential cellular functions. Parvalbumin is a calcium buffering protein that regulates intracellular calcium concentrations. It prevents rises in calcium concentrations... -
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- Focal Cerebral Ischemia Induces Decrease of Astrocytic Phosphoprotein PEA-15 in Brain Tissue and HT22 Cells
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Koh PO
- KMID: 2312083
- Lab Anim Res.
- 2010 Sep;26(3):311-314.
PEA-15 is a small phosphoprotein (15 kDa) that is enriched in brain astrocytes. PEA-15 acts as an important modulator of cellular function including apoptosis and signal integration. This study investigated... -
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- Gingko biloba extract (EGb 761) attenuates ischemic brain injury-induced reduction in Ca2+ sensor protein hippocalcin
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Koh PO
- KMID: 1436725
- Lab Anim Res.
- 2012 Sep;28(3):199-204.
- doi: 10.5625/lar.2012.28.3.199
Gingko biloba extract 761 (EGb 761) protects neuronal cells from ischemic brain injury via a number of neuroprotective mechanisms. Hippocalcin is a calcium sensor protein that regulates intracellular calcium concentrations... -
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- Decrease of protein phosphatase 2A subunit B by glutamate exposure in the cerebral cortex of neonatal rats
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Kang JB, Park DJ, Son HK, Koh PO
- KMID: 2507241
- Lab Anim Res.
- 2020 Sep;36(3):279-287.
- doi: 10.1186/s42826-020-00064-y
Glutamate induces neurotoxicity during brain development, causing nerve damage. Protein phosphatase 2A (PP2A) is a type of serine/threonine phosphatase that regulates various biological functions. Among the PP2A subunit types, subunit... -
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- Alleviation of γ-enolase decrease by the chlorogenic acid administration in the stroke animal model
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Kang JB, Shah MA, Ko MS, Koh PO
- KMID: 2543752
- Korean J Vet Res.
- 2023 Mar;63(1):e6.
- doi: 10.14405/kjvr.20230008
Stroke is a major cause of death and long-term disability. Chlorogenic acid is a phenolic compound with a potent neuroprotective effect. γ-enolase is a phosphopyruvate hydratase found in mature neurons... -
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- Ischemic brain injury decreases dynamin-like protein 1 expression in a middle cerebral artery occlusion animal model and glutamate-exposed HT22 cells
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Jang AR, Koh PO
- KMID: 2362910
- Lab Anim Res.
- 2016 Dec;32(4):194-199.
- doi: 10.5625/lar.2016.32.4.194
Dynamin-like protein I (DLP-1) is an important mitochondrial fission and fusion protein that is associated with apoptotic cell death in neurodegenerative diseases. In this study, we investigated DLP-1 expression in... -
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- Curcumin attenuates the middle cerebral artery occlusion-induced reduction in gamma-enolase expression in an animal model
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Gim SA, Lee SR, Shah FA, Koh PO
- KMID: 2312146
- Lab Anim Res.
- 2015 Dec;31(4):198-203.
- doi: 10.5625/lar.2015.31.4.198
Curcumin exerts a protective effect in cerebral ischemia through its anti-oxidant and anti-inflammatory activities. gamma-enolase is a glycolytic enzyme expressed in neurons that is known to exerts a neuroprotective effect.... -
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- Ferulic acid modulates nitric oxide synthase expression in focal cerebral ischemia
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Koh PO
- KMID: 1431411
- Lab Anim Res.
- 2012 Dec;28(4):273-278.
- doi: 10.5625/lar.2012.28.4.273
Nitric oxide (NO) is generated by three different NO synthase (NOS) isoforms, endothelial NOS (eNOS), inducible NOS (iNOS), and neuronal NOS (nNOS). It is known that eNOS produces NO, which... -
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- Focal Cerebral Ischemia Reduces Protein Phosphatase 2A Subunit B Expression in Brain Tissue and HT22 Cells
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Koh PO
- KMID: 2391863
- Lab Anim Res.
- 2011 Mar;27(1):73-76.
Protein phosphatase 2A (PP2A) is a serine and threonine protein phosphatase that regulates cell cycle progression and apoptosis. PP2A is composed of various subunits. Among these subunits, subunit B plays... -
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- Cerebral ischemic injury decreases α-synuclein expression in brain tissue and glutamate-exposed HT22 cells
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Koh PO
- KMID: 2391098
- Lab Anim Res.
- 2017 Sep;33(3):244-250.
- doi: 10.5625/lar.2017.33.3.244
α-Synuclein is abundantly expressed in neuronal tissue, plays an essential role in the pathogenesis of neurodegenerative disorders, and exerts a neuroprotective effect against oxidative stress. Cerebral ischemia causes severe neurological... -
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- Decrease of 14–3-3 proteins by glutamate exposure in the cerebral cortex of newborn rats
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Kang JB, Lee SY, Park DJ, Koh PO
- KMID: 2506038
- Lab Anim Res.
- 2020 Jun;36(2):119-125.
- doi: 10.1186/s42826-020-00041-5
Glutamate is a representative excitatory neurotransmitter. However, excessive glutamate exposure causes neuronal cell damage by generating neuronal excitotoxicity. Excitotoxicity in neonates caused by glutamate treatment induces neurological deficits in adults.... -
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- Quercetin ameliorates glutamate toxicity-induced neuronal cell death by controlling calcium-binding protein parvalbumin
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Kang JB, Kang JB, Park DJ, Shah MA, Koh PO
- KMID: 2527878
- J Vet Sci.
- 2022 Mar;23(2):e26.
- doi: 10.4142/jvs.21273
Background: Glutamate is the main excitatory neurotransmitter. Excessive glutamate causes excitatory toxicity and increases intracellular calcium, leading to neuronal death. Parvalbumin is a calcium-binding protein that regulates calcium homeostasis. Quercetin... -
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- Focal cerebral ischemic injury decreases calbindin expression in brain tissue and HT22 cells
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Ouh IO, Kim YM, Gim SA, Koh PO
- KMID: 2312108
- Lab Anim Res.
- 2013 Sep;29(3):156-161.
Calbindin is a calcium binding protein that controls intracellular calcium levels and has a neuroprotective function against apoptotic stimuli. We investigated the expression of calbindin in ischemic brain injury. Focal... -
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- Hyperglycemia decreases preoxiredoxin-2 expression in a middle cerebral artery occlusion model
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Koh PO
- KMID: 2407422
- Lab Anim Res.
- 2017 Jun;33(2):98-104.
- doi: 10.5625/lar.2017.33.2.98
Diabetes is a major risk factor for stroke and is also associated with worsened outcomes following a stroke. Peroxiredoxin-2 exerts potent neuroprotective effects against oxidative stress. In the present study,... -
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- Ferulic acid prevents the injury-induced decrease of gamma-enolase expression in brain tissue and HT22 cells
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Gim SA, Koh PO
- KMID: 2312114
- Lab Anim Res.
- 2014 Mar;30(1):8-13.
Ferulic acid is known to act as a protective agent in cerebral ischemia through its anti-oxidant activity. gamma-Enolase is a neuron-specific enolase that also exerts a neuroprotective effect. Here, we... -
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- Estradiol attenuates down-regulation of PEA-15 and its two phosphorylated forms in ischemic brain injury
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Koh PO
- KMID: 1787650
- Lab Anim Res.
- 2015 Mar;31(1):40-45.
- doi: 10.5625/lar.2015.31.1.40
Estradiol exerts a neuroprotective effect against focal cerebral ischemic injury through the inhibition of apoptotic signals. Phosphoprotein enriched in astrocytes 15 (PEA-15) is mainly expressed in brain that perform anti-apoptotic... -
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- Effect of Deuterium Oxide on Urological Cancer Cells
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Park MS, Hahn CH, Koh PO, Kim JH, Kim MO, Bahk JY
- KMID: 2293855
- Korean J Urol.
- 2005 Oct;46(10):1098-1105.
PURPOSE: To evaluate the antiproliferative activity of deuterium oxide (D2O) on urological cancer cells for the application of D2O in the treatment of urological cancer. MATERIALS AND METHODS: Urological cancer cell... -
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- Expression of placenta growth factor mRNA in the rat placenta during mid-late pregnancy
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Choi WS, Cho GJ, Won CK, Koh PO
- KMID: 1091196
- J Vet Sci.
- 2005 Sep;6(3):179-183.
The placenta is an essential organ that synthesizes several growth and angiogenic factors for its own growth as well as fetal development. It is known that the placenta growth factor... -
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- Hyperglycemia exacerbates downregulation of dynamin-like protein 1 in ischemic cerebral injury
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Park DJ, Kim MO, Koh PO
- KMID: 2391092
- Lab Anim Res.
- 2017 Sep;33(3):202-208.
- doi: 10.5625/lar.2017.33.3.202
Ischemic stroke is one of the leading causes of adult disability and death. Hyperglycemia is associated with an increased risk of stroke and poor outcomes after brain injury. Dynamin-like protein... -
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- Proteomic Analysis of Hepatic Ischemia and Reperfusion Injury in Mice
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Cho EH, Sung JH, Koh PO
- KMID: 1458942
- Lab Anim Res.
- 2010 Mar;26(1):69-74.
- doi: 10.5625/lar.2010.26.1.69
Hepatic ischemia/reperfusion (I/R) injury is an inevitable consequence during liver surgery. I/R injury induces serious hepatic dysfunction and failure. In this study, we identified proteins that were differentially expressed between... -
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