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Bone Generation Following Repeated Administration of Recombinant Bone Morphogenetic Protein 2

Son HJ, Lee MN, Kim Y, Choi H, Jeong BC, Oh SH, Kim JW, Kwon SH, Kim SH, Song SC, Lee SE, Koh JT

BACKGROUND: The delivery of recombinant human bone morphogenetic protein 2 (rhBMP2) by using various carriers has been used to successfully induce bone formation in many animal models. However, the effect...
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Trends in End-of-Life Resource Utilization and Costs among Prostate Cancer Patients from 2006 to 2015: A Nationwide Population-Based Study

Ha YS, Kim SY, Chung JI, Choi H, Kim JH, Yu HS, Cho IC, Kim HJ, Chung HC, Koh JS, Lee JY, Park DJ, Kim HT, Yoo ES, Kwon TG, Min K, Kim WJ, Yun SJ, Park JH

Purpose:The purpose of this study was to evaluate end-of-life resource utilization and costs for prostate cancer patients during the last year of life in Korea. Materials and Methods:The study used the...
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Astragalin Inhibits Nuclear Factor-κB Signaling in Human Colonic Epithelial Cells and Attenuates Experimental Colitis in Mice

Han YM, Koh J, Kim JH, Lee J, Im JP, Kim JS

Background/Aims: Astragalin (kaempferol-3-O-β-D-glucoside) is a flavonoid isolated from the leaves of persimmon or Rosa agrestis. Astragalin exhibits various anti-inflammatory properties; however, little is known about its therapeutic potential for inflammatory...
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Prediction of TP53 mutations by p53 immunohistochemistry and their prognostic significance in gastric cancer

Hwang HJ, Nam SK, Park H, Park Y, Koh J, Na HY, Kwak Y, Kim WH, Lee HS

Background: Recently, molecular classifications of gastric cancer (GC) have been proposed that include TP53 mutations and their functional activity. We aimed to demonstrate the correlation between p53 immunohistochemistry (IHC) and...
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PD-L1 Testing in Gastric Cancer by the Combined Positive Score of the 22C3 PharmDx and SP263 Assay with Clinically Relevant Cut-offs

Park Y, Koh J, Na HY, Kwak Y, Lee KW, Ahn SH, Park DJ, Kim HH, Lee HS

Purpose We provide a comparison between 22C3 pharmDx and SP263 assay, for evaluating programmed death ligand 1 (PD-L1) expression in advanced gastric cancer (GC) patients. Materials and Methods The PD-L1 immunohistochemistry...
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Changes in uroplakin expression in the urothelium of patients with ulcerative interstitial cystitis/ bladder pain syndrome

Cho KJ, Lee KS, Choi JB, Koh JS, Kim JC

Purpose: We evaluated changes in the expression of uroplakin (UP) in the urothelium of patients with ulcerative interstitial cystitis/ bladder pain syndrome (IC/BPS). Materials and Methods: Bladder samples were collected from...
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Contribution of Personality Traits,Psychological Factors, and Health-Related Qualityof Life to Medication Adherence in Patientswith Rheumatoid Arthritis

Ko KM, Moon SJ, Koh JH, Pae CU, Min JK

Purpose: This study sought to investigate the associations between personality traits and medication adherence and to identify predictors of good medication adherence in rheumatoid arthritis (RA) patients. Materials and Methods: A total...
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Morphologic variant of follicular lymphoma reminiscent of hyaline-vascular Castleman disease

Koh J, Jeon YK

Follicular lymphoma (FL) with hyaline-vascular Castleman disease (FL-HVCD)-like features is a rare morphologic variant, with fewer than 20 cases in the literature. Herein, we report a case of FL-HVCD in...
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Perioperative Management of Anemia Based on Patient Blood Management

Koh JW

Perioperative anemia is common during surgery and is an important risk factor for the transfusion of RBC, morbidity and mortality. Blood transfusion has been a common practice for a long...
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Potential Biomarkers to Improve the Prediction of Osteoporotic Fractures

Kim BJ, Lee SH, Koh JM

Osteoporotic fracture (OF) is associated with high disability and morbidity rates. The burden of OF may be reduced by early identification of subjects who are vulnerable to fracture. Although the...
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Changes in plasma lipoxin A4, resolvins and CD59 levels after ischemic and traumatic brain injuries in rats

Jung JS, Kho AR, Lee SH, Choi BY, Kang SH, Koh JY, Suh SW, Song DK

Ischemic and traumatic brain injuries are the major acute central nervous system disorders that need to be adequately diagnosed and treated. To find biomarkers for these acute brain injuries, plasma...
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Analysis of Poisoning Patients Using 2017-18 ED Based Injury in-depth Surveillance Data

Koh J, Jeon W, Kang H, Kim YW, Kim H, Oh BJ, Lee MJ, Chun BJ, Chung SP, Kim KH

Purpose: The annual statistics for poisoning are reported based on the data from poison control centers in many advanced countries. In 2016 a study was conducted to analyze the 2016...
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Immunological Characteristics of Hyperprogressive Disease in Patients with Non-small Cell Lung Cancer Treated with Anti-PD-1/PD-L1 Abs

Kim KH, Hur JY, Koh J, Cho J, Ku BM, Koh JY, Sun JM, Lee SH, Ahn JS, Park K, Ahn MJ, Shin EC

Hyperprogressive disease (HPD) is a distinct pattern of progression characterized by acceleration of tumor growth after treatment with anti-PD-1/PD-L1 Abs. However, the immunological characteristics have not been fully elucidated in...
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Tryptophanyl-tRNA Synthetase Sensitizes Hormone Receptor-Positive Breast Cancer to Docetaxel-Based Chemotherapy

Lee KM, Hwang EH, Kang SE, Lee CH, Lee H, Oh HJ, Kim K, Koh J, Ryu HS

Purpose: A relatively low response to chemotherapy has been reported for hormone receptor (HR)-positive breast cancer. In this study, we investigated the role of tryptophanyl-transfer RNA synthetase (WARS) in the...
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Application of purified porcine collagen in patients with chronic refractory musculoskeletal pain

Seong H, Kim RK, Shin Y, Lee HW, Koh JC

Background: This study aimed to assess the potential efficacy of purified porcine atelocollagen (PAC) for the management of refractory chronic pain due to suspected connective tissue damage. Methods: Patients treated with...
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Pneumatosis Intestinalis and Pneumomediastinum in Patients With Granulomatosis With Polyangiitis

Kim A, Koh JH

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High-Throughput Multiplex Immunohistochemical Imaging of the Tumor and Its Microenvironment

Koh J, Kwak Y, Kim J, Kim WH

Purpose The aim of this study was to develop a formalin-fixed paraffin-embedded (FFPE) tissue based multiplex immunochemistry (mIHC) method for high-throughput comprehensive tissue imaging and demonstrate its feasibility, validity, and usefulness. Materials...
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Two Cases of Pediatric Pneumolabyrinth with Traumatic Tympanic Membrane Perforation after Penetrating Injury

You YS, Koh JH, Kim BJ, Lee EJ

Pneumolabyrinth is an uncommon condition in which air is present in the vestibule or cochlear. It is rarely found, even in otic capsule violating fractures or in transverse fracture of...
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Endovascular Treatments Performed Collaboratively by the Society of Korean Endovascular Neurosurgeons Members: A Nationwide Multicenter Survey

Kim TG, Kwon O, Shin YS, Sung JH, Koh JS, Kim BT

OBJECTIVE: Since less invasive endovascular treatment was introduced to South Korea in 1994, a considerable proportion of endovascular treatments have been performed by neuroradiology doctors, and endovascular treatments by vascular...
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The Effect of Daily Low Dose Tadalafil on Cerebral Perfusion and Cognition in Patients with Erectile Dysfunction and Mild Cognitive Impairment

Choi JB, Cho KJ, Kim JC, Kim CH, Chung YA, Jeong HS, Shim YS, Koh JS

OBJECTIVE: The aims of this study were to investigate the effects of daily low-dose tadalafil on cognitive function and to examine whether there was a change in cerebral blood flow...
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