- MHY2251, a New SIRT1 Inhibitor, Induces Apoptosis via JNK/p53 Pathway in HCT116 Human Colorectal Cancer Cells
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Kang YJ, Kwon YH, Jang JY, Lee JH, Lee S, Park Y, Moon HR, Chung HY, Kim ND
- KMID: 2537583
- Biomol Ther.
- 2023 Jan;31(1):73-81.
- doi: 10.4062/biomolther.2022.044
Sirtuins (SIRTs) belong to the nicotinamide adenine dinucleotide (NAD+)-dependent class III histone deacetylase family. They are key regulators of cellular and physiological processes, such as cell survival, senescence, differentiation, DNA... -
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- Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells
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Kim MJ, Kang YJ, Sung B, Jang JY, Ahn YR, Oh HJ, Choi H, Choi I, Im E, Moon HR, Chung HY, Kim ND
- KMID: 2508211
- Biomol Ther.
- 2020 Nov;28(6):561-568.
- doi: 10.4062/biomolther.2020.153
We examined the anticancer effects of a novel sirtuin inhibitor, MHY2256, on HCT116 human colorectal cancer cells to investigate its underlying molecular mechanisms. MHY2256 significantly suppressed the activity of sirtuin... -
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- Characterization of Oncolytic Vaccinia Virus Harboring the Human IFNB1 and CES2 Transgenes
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Cho E, Islam SMBU, Jiang F, Park JE, Lee B, Kim ND, Hwang TH
- KMID: 2501223
- Cancer Res Treat.
- 2020 Jan;52(1):309-319.
- doi: 10.4143/crt.2019.161
Purpose The purpose of this study was to assess characteristics of SJ-815, a novel oncolytic vaccinia virus lacking a functional thymidine kinase-encoding TK gene, and instead, having two human transgenes: the... -
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- Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5
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Karunakaran U, Elumalai S, Moon JS, Jeon JH, Kim ND, Park KG, Won KC, Leem J, Lee IK
- KMID: 2442772
- Diabetes Metab J.
- 2019 Apr;43(2):192-205.
- doi: 10.4093/dmj.2018.0052
BACKGROUND: Chronic hyperglycemia has deleterious effects on pancreatic β-cell function and turnover. Recent studies support the view that cyclin-dependent kinase 5 (CDK5) plays a role in β-cell failure under hyperglycemic... -
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- Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
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Sung B, Chung HY, Kim ND
- KMID: 2367558
- J Cancer Prev.
- 2016 Dec;21(4):216-226.
- doi: 10.15430/JCP.2016.21.4.216
Apigenin (4′,5,7-trihydroxyflavone) is a flavonoid commonly found in many fruits and vegetables such as parsley, chamomile, celery, and kumquats. In the last few decades, recognition of apigenin as a cancer... -
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- Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain
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Kim DJ, Choi CK, Lee CS, Park MH, Tian X, Kim ND, Lee KI, Choi JK, Ahn JH, Shin EY, Shin I, Kim EG
- KMID: 2361516
- Exp Mol Med.
- 2016 Apr;48(4):e229.
- doi: 10.1038/emm.2016.13
p21-activated kinases (PAKs) are key regulators of actin dynamics, cell proliferation and cell survival. Deregulation of PAK activity contributes to the pathogenesis of various human diseases, including cancer and neurological... -
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- Viriditoxin Induces G2/M Cell Cycle Arrest and Apoptosis in A549 Human Lung Cancer Cells
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Park JH, Noh TH, Wang H, Kim ND, Jung JH
- KMID: 2312911
- Nat Prod Sci.
- 2015 Dec;21(4):282-288.
- doi: 10.20307/nps.2015.21.4.282
Viriditoxin is a fungal metabolite isolated from Paecilomyces variotii, which was derived from the giant jellyfish Nemopilema nomurai. Viriditoxin was reported to inhibit polymerization of FtsZ, which is a key... -
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- Mutation analysis of PAH gene and characterization of a recurrent deletion mutation in Korean patients with phenylketonuria
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Lee YW, Lee DH, Kim ND, Lee ST, Ahn JY, Choi TY, Lee YK, Kim SH, Kim JW, Ki CS
- KMID: 1104807
- Exp Mol Med.
- 2008 Oct;40(5):533-540.
- doi: 10.3858/emm.2008.40.5.533
Phenylketonuria (PKU; MIM 261600) is an autosomal recessive metabolic disorder caused by a deficiency of phenylalanine hydroxylase (PAH; EC 1.14.16.1). Point mutations in the PAH gene are known to cause... -
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- Modulation of Apoptosis and Cell Cycle by Synthetic Bile Acid Derivatives
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Park SE, Im EO, Choi YH, Kim ND, Yoo YH
- KMID: 2092912
- Korean J Anat.
- 2008 Mar;41(1):1-11.
This paper outlines the current understanding of cell cycle modulation and induction of apoptosis in cancer cells by natural and synthetic bile acid. Bile acid homeostasis is tightly regulated in... -
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- A Case of Primary Extranodal NK/T Cell Lung Lymphoma Presenting as Multiple Patchy Pulmonary Infiltrations
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Jung GM, Kwak JY, Choi HJ, Park HS, Chang M, Lee KM, Kim ND, Park YJ, Kim KW
- KMID: 2318460
- Tuberc Respir Dis.
- 2003 Dec;55(6):636-642.
Primary lung lymphoma is an uncommon tumor, which constitutes 0.5% of primary lung cancer, and 3% of extranodal lymphoma. The most frequent radiologic presentation of pulmonary parenchymal lymphoma is single... -
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- Positron Emission Tomography with 18F Fluorodeoxyglucose for Primary Lymphoma of Bone
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Kim ND, Park YH, Ki SS, Park YJ, Kim HJ, Ryoo BY, Kim HT, Kim S, Cheon GJ, Choi CW, Lim SM
- KMID: 2078747
- Korean J Nucl Med.
- 2003 Oct;37(5):331-335.
PURPOSE: Accurate assessment of the lesion after treatment of patients with bone lymphoma is difficult. In this patient who demonstrated complete remission after chemotherapy, the regions of fluorine-18 fluorodeoxyglucose (... -
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- A case of non small cell lung cancer presenting with systemic lupus erythematosus(SLE)
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Ki SS, Kim ND, Kim HJ, Park YJ, Park YH, Ryoo BY, Kim HT, Park SH
- KMID: 1985139
- Korean J Med.
- 2002 Nov;63(5):600-601.
No abstract available. -
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- Comparison of Doppler Ultrasonography and Hepatic Venous Pressure Gradient in Assessing Portal Hypertension in Liver Cirrhosis
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Jeong PH, Baik SK, Choi YJ, Park DH, Kim MY, Kim HS, Lee DK, Kwon SO, Kim YJ, Park JW, Kim ND
- KMID: 863096
- Korean J Hepatol.
- 2002 Sep;8(3):264-270.
BACKGROUND/AIMS: This prospective study aimed to determine if Doppler ultrasonography can be representative of hepatic venous pressure gradient (HVPG) in assessing the severity of portal hypertension and response to... -
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- Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro
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Kim JW, Kang KW, Oh GT, Song J, Kim ND, Pak YK
- KMID: 1081463
- Exp Mol Med.
- 2002 May;34(2):137-144.
Cholesterol-rich diet impairs endothelial NO synthase (eNOS) and enhances inducible NOS (iNOS) expression. In this study, we investigated effects of cholesterol on iNOS expression in high-fat-fed rat models, HepG2 and... -
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- Relation Between Expression of p53 Proteins and Established Prognostic Factors in Breast Carcinomas
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Bae YT, Kwak HS, Sol MY, Kim ND
- KMID: 2206458
- J Korean Surg Soc.
- 1999 Apr;56(4):491-500.
BACKGROUND: Recent studies have conflicting results concerning the role of p53 protein related to the discovery that a wild-type of p53 is a nuclear protein that plays a role both... -
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- Clinical study of alcoholic liver disease
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Kim ND, Kwon SO, Kim HS, Lee DK, Bae SW, Jang WI, Kim H, Park C
- KMID: 1698179
- Korean J Intern Med.
- 1992 Aug;43(2):161-168.
No abstract available. -
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- Intussusception into the enteroanastomosis after Billroth II gastric resection; diagnosed by gastroscopy
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Jang WI, Kim ND, Bae SW, Kim WT, Kwon SO, Yoon KS, Kim SY
- KMID: 1421448
- J Korean Med Sci.
- 1989 Mar;4(1):51-54.
- doi: 10.3346/jkms.1989.4.1.51
A case of retrograde intussusception (acute type) of efferent limb into Braun side-to-side jejuno-jejunal anastomosis is presented. Intussusception, though infrequent, is well recognized complication after gastric surgery. Patient was 50... -
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- Testis Biopsy in Infertile Men with Azospermia
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Kim ND, Lee HS
- KMID: 1911705
- Korean J Urol.
- 1983 Feb;24(1):123-126.
Concepts regarding the evaluation and management of the infertile male have evolved during the past decade primarily because of the development of new methodology. Nevertheless, the causes of male infertility... -
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- Suprapubic Ultrasonographic Findings of the Prostatic Diseases
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Kim ND, Kwon SW
- KMID: 1911779
- Korean J Urol.
- 1982 Jul;23(4):479-486.
There have been much limitations and errors in evaluating prostatic conditions by traditional radiologic methods due to its location and anatomical structure. However recent introduction and improvement of the ultrasonography... -
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- A Case of Single Ectopic Ureter
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Kim ND, Choi KS, Lee HS, Kwon SW
- KMID: 1969498
- Ewha Med J.
- 1981 Mar;4(1):33-36.
- doi: 10.12771/emj.1981.4.1.33
The term of ectopic ureter means the ureter which opens at a point other than ther lateral horn of the interureteric ridge. Single ectopic ureter ureter is very rare and... -
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