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Autophagy inhibition by cudraxanthone D regulates epithelial–mesenchymal transition in SCC25 cells

Yu SB, Bang TH, Kang HM, Park BS, Kim IR

Cudraxanthone D (CD) is a natural xanthone compound derived from the root barks of Cudrania tricuspidata . However, the biological functions of CD in human metabolism have been rarely reported...
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Anticancer effects of D-pinitol in human oral squamous carcinoma cells

Shin HC, Bang TH, Kang HM, Park BS, Kim IR

D-pinitol is an analog of 3-methoxy-D-chiro-inositol found in beans and plants. D-pinitol has anti-inflammatory, antidiabetic, and anticancer effects. Additionally, D-pinitol induces apoptosis and inhibits metastasis in breast and prostate cancers....
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Surgical impact on anxiety of patients with breast cancer: 12-month follow-up prospective longitudinal study

Kim J, Cho J, Lee SK, Choi EK, Kim IR, Lee JE, Kim SW, Nam SJ

Purpose: Breast cancer diagnosis and treatment often produce stress in patients. Anxiety is one of the most prevalent psychological symptoms perceived by breast cancer patients. This study aims to evaluate...
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Piperlongumine suppressed osteoclastogenesis in RAW264.7 macrophages

Jin SM, Kang HM, Park DB, Yu SB, Kim IR, Park BS

Piperlongumine (PL) is a natural product found in long pepper (Piper longum). The pharmacological effects of PL are well known, and it has been used for pain, hepatoprotection, and asthma...
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Comparison of quality of life and depression between hematopoietic stem cell transplantation survivors and their spouse caregivers

Park S, Choi EK, Kim IR, Cho J, Jang JH

BACKGROUND: Hematopoietic stem cell transplantation (HSCT) is an exhausting process that impacts both the patient and caregiver. METHODS: This was a cross-sectional, HSCT survivor-spouse caregiver matching study to determine quality of...
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Combined effect of recombinant human bone morphogenetic protein-2 and low level laser irradiation on bisphosphonate-treated osteoblasts

Jeong SY, Hong JU, Song JM, Kim IR, Park BS, Kim CH, Shin SH

OBJECTIVES: The purpose of this study was to evaluate the synergic effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) and low-level laser therapy (LLLT) on bisphosphonate-treated osteoblasts. MATERIALS AND METHODS: Human...
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Combined Treatment with Low-Level Laser and rhBMP-2 Promotes Differentiation and Mineralization of Osteoblastic Cells under Hypoxic Stress

Heo JH, Choi JH, Kim IR, Park BS, Kim YD

BACKGROUND: The aim of this study was to evaluate the combined effect of low-level laser treatment (LLLT) and recombinant human bone morphological protein-2 (rhBMP-2) applied to hypoxic-cultured MC3T3-E1 osteoblastic cells...
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Health-Related Quality of Life in Non-Hodgkin Lymphoma Survivors: A Prospective Cohort Study

Kang D, Cho J, Kim IR, Kim MK, Kim WS, Kim SJ

PURPOSE: We evaluated health-related quality of life (HRQOL) in long-term survivors of indolent and aggressive non-Hodgkin lymphoma (NHL). MATERIALS AND METHODS: TheHRQOLwas assessed by the European Organization for Research and Treatment...
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Luteolin Induces Apoptosis via Mitochondrial Pathway and Inhibits Invasion and Migration of Oral Squamous Cell Carcinoma by Suppressing Epithelial-Mesenchymal Transition Induced Transcription Factors

Park BS, Kil JJ, Kang HM, Yu SB, Park DB, Park JA, Kim IR

Oral squamous cell carcinoma (OSCC) is the most common type of oral malignancy. Numerous therapies have been proposed for its cure. Research is continually being conducted to develop new forms...
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Validation of the Korean Version of the Quality of Life–Cancer Survivors (QOL-CS-K) Questionnaire in Lymphoma Survivors

Cho J, Kang D, Kim IR, Kim WS, Ferrell B, Kim SJ

PURPOSE: The objective of this study was to validate the Korean version of the Quality of Life–Cancer Survivors (QOL-CS-K) in a sample of lymphoma survivors. MATERIALS AND METHODS: We conducted a...
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Discomfort related to Peripherally Inserted Central Catheters in Cancer Patient

Yi M, Kim IR, Choi EK, Lee S, Kwak M, Cho J, Ahn JS, Kwon IG

PURPOSE: This study aimed to assess the discomfort and factors influencing the discomfort of cancer patients with peripherally inserted central catheters (PICC). METHODS: A cross-sectional survey was conducted at a tertiary...
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Effect of low-level laser therapy on bisphosphonate-treated osteoblasts

Shin SH, Kim KH, Choi NR, Kim IR, Park BS, Kim YD, Kim UK, Kim CH

BACKGROUND: This study investigates the effect of alendronate-treated osteoblasts, as well as the effect of low-level laser therapy (LLLT) on the alendronate-treated osteoblasts. Bisphosphonate decreases the osteoblastic activity. Various treatment...
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Synergistic Effects of Chios Gum Mastic Extract and Low Level Laser Therapy on Osteoblast Differentiation

Lee KH, Kim YS, Yu SB, Kang HM, Kwak HH, Kim IR, Park BS

In the present study, we evaluated the effect of CGM on osteogenic differentiation of cultured osteoblasts, and determined whether combination treatment with LLLT had synergistic effects on osteogenic differentiation. The results...
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Anticancer Properties of Icariside II in Human Oral Squamous Cell Carcinoma Cells

Kim IR, Kim YS, Yu SB, Kang HM, Kwak HH, Park BS

OSCC is currently the most common malignancy of the head and neck, affecting tens of thousands of patients per year worldwide. Natural flavonoids from plants are potential sources for novel...
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Low-level laser therapy affects osseointegration in titanium implants: resonance frequency, removal torque, and histomorphometric analysis in rabbits

Kim JR, Kim SH, Kim IR, Park BS, Kim YD

OBJECTIVES: The purpose of this study was to investigate the effects of low-level laser therapy (LLLT) with a diode gallium-aluminum-arsenide (Ga-Al-As) low-level laser device on the healing and attachment of...
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Combined effect of bisphosphonate and recombinant human bone morphogenetic protein 2 on bone healing of rat calvarial defects

Kim HC, Song JM, Kim CJ, Yoon SY, Kim IR, Park BS, Shin SH

PURPOSE: This study aimed to investigate new bone formation using recombinant human bone morphogenetic protein 2 (rhBMP-2) and locally applied bisphosphonate in rat calvarial defects. METHODS: Thirty-six rats were studied. Two...
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Autophagy Inhibition Promotes Quercetin Induced Apoptosis in MG-63 Human Osteosarcoma cells

Park SJ, Yu SB, Kim YH, Kim IR, Park HR, Park BS

Quercetin is a natural flavonoid phytochemical that is extracted from various plants. Having an advantages due to its varied biological properties, such as anti-inflammatory, anti-viral, anti-oxidant, and anti-cancer effects, quercetin...
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Mechanism Underlying Shikonin-induced Apoptosis and Cell Cycle Arrest on SCC25 Human Tongue Squamous Cell Carcinoma Cell Line

Oh SH, Park SJ, Yu SB, Kim YH, Kim IR, Park BS

Shikonin, a major ingredient in the traditional Chinese herb Lithospermumerythrorhizon, exhibits multiple biological functions including antimicrobial, anti-inflammatory, and antitumor effects. It has recently been reported that shikonin displays antitumor properties...
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NaF-induced Autophagy on SCC25 Human Tongue Squamous Cell Carcinoma Cells

Kang JM, Lee BY, Kim IR, Kim YH, Yu SB, Park HR, Park BS

Fluoride has been accepted as an important material for oral health and is widely used to prevent dental caries in dentistry. However, its safety is still questioned by some. Autophagy...
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Effect of recombinant human bone morphogenetic protein-2 on bisphosphonate-treated osteoblasts

Kwon TK, Song JM, Kim IR, Park BS, Kim CH, Cheong IK, Shin SH

OBJECTIVES: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a side effect of bisphophonate therapy that has been reported in recent years. Osteoclastic inactivity by bisphosphonate is the known cause of...
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