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The Use of CD44 Variant 9 and Ki-67 Combination Can Predicts Prognosis Better Than Their Single Use in Early Gastric Cancer

Go SI, Ko GH, Lee WS, Lee JH, Jeong SH, Lee YJ, Hong SC, Ha WS

PURPOSE: We previously demonstrated that CD44v9 and Ki-67 played an important role in predicting poor prognosis of early gastric cancer (EGC). However, little is known about combined use of both...
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Role of co-expression of estrogen receptor beta and Ki67 in prostate adenocarcinoma

Azizan N, Hayati F, Tizen NM, Farouk WI, Masir N

PURPOSE: To evaluate the expression of estrogen receptor (ER)-beta and Ki67 in prostate cancer and study their relationship. MATERIALS AND METHODS: We analyzed 101 cases of prostate adenocarcinoma diagnosed from January...
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Cytokeratin 13, Cytokeratin 17, and Ki-67 Expression in Human Acquired Cholesteatoma and Their Correlation With Its Destructive Capacity

Hamed MA, Nakata S, Shiogama K, Suzuki K, Sayed RH, Nishimura , Iwata N, Sakurai K, Badawy BS, Inada K, Tsuge H, Tsutsumi Y

OBJECTIVES: Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity. Continued research is...
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High Histologic Grade and High Ki-67 Expression Predict Phenotypic Alterations in Node Metastasis in Primary Breast Cancers

Mandó P, Rizzo M, de la Puente CP, Maino M, Ponce C, Pombo MT, Amat M, Costanzo M, Nervo A, Nadal J, Fabiano V, Loza J, Loza CM, Colo F, Reinaldo C

PURPOSE: Several studies have shown that estrogen receptor (ER) and progesterone receptor (PR) expression and human epidermal growth factor receptor 2 (HER2) expression may vary during tumoral progression. We aimed...
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The Predictive Value of Pathologic Features in Pituitary Adenoma and Correlation with Pituitary Adenoma Recurrence

Kim JS, Lee YS, Jung MJ, Hong YK

BACKGROUND: The 2004 World Health Organization classification introduced atypical pituitary adenoma (aPA), which was equivocally defined as invasion with increased mitotic activity that had a Ki-67 labeling index (LI) greater...
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Differences in Clinical Outcomes between Luminal A and B Type Breast Cancers according to the St. Gallen Consensus 2013

Ahn HJ, Jung SJ, Kim TH, Oh MK, Yoon HK

PURPOSE: Human epidermal growth factor receptor 2 (HER2)-positive luminal B type comprises estrogen receptor (ER)-positive and HER2-positive cancers, and HER2-negative luminal B type comprises ER-positive cancers showing a Ki-67 labeling...
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Ki-67 and p53 expression as a predictive marker for early postoperative recurrence in pancreatic head cancer

Kim H, Park CY, Lee JH, Kim JC, Cho CK, Kim HJ

PURPOSE: This study aimed to evaluate the clinical significance of Ki-67 and p53 expressions in patients with pancreatic head cancer. METHODS: Between May 2008 and April 2013, immunohistochemical staining for Ki-67...
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Prognostic Significance of Ki-67 Expression in Patients Undergoing Surgical Resection for Gastrointestinal Stromal Tumor

Jeong SY, Park WW, Kim YS, Park YI, Kim SH, Yoon WJ, Moon JS, Lee BM, Hong SW, Kang YK

BACKGROUND/AIMS: Assessment of malignant potential in gastrointestinal stromal tumor (GIST) is still problematic. The maximum tumor diameter and the mitotic index are generally used as an index of malignancy of...
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Ki-67 as a Predictor of Response to Neoadjuvant Chemotherapy in Breast Cancer Patients

Kim KI, Lee KH, Kim TR, Chun YS, Lee TH, Park HK

  • KMID: 2353082
  • J Breast Cancer.
  • 2014 Mar;17(1):40-46.
PURPOSE: The objectives of this study were to assess the potential value of Ki-67 in predicting response to neoadjuvant chemotherapy in breast cancer patients and to suggest a reasonable cutoff...
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Prognostic Value of the Nodal Ratio and Ki-67 Expression in Breast Cancer Patients Treated with Postmastectomy Radiotherapy

Koo TR, Eom KY, Kang EY, Kim YJ, Kim SW, Kim JH, Kim JS, Kim IA

PURPOSE: This pilot study aimed to evaluate prognostic factors of postmastectomy radiotherapy (PMRT) for breast cancer patients undergoing systemic therapy in either preoperative or postoperative setting. METHODS: Between 2003 and 2009,...
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Prognostic Significance of Heat Shock Protein 70 Expression in Early Gastric Carcinoma

Kang Y, Jung WY, Lee H, Jung W, Lee E, Shin BK, Kim A, Kim HK, Kim BH

  • KMID: 2277438
  • Korean J Pathol.
  • 2013 Jun;47(3):219-226.
BACKGROUND: Overexpression of heat shock protein 70 (HSP70) has been observed in many types of cancer including gastric adenocarcinomas, although the exact role of HSP70 in carcinogenesis remains unclear. METHODS: The...
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Long-term follow-up may be needed for pancreaticobiliary reflux in healthy adults

Yun SP, Lee JY, Jo HJ, Kim HS, Kim DH, Kim JH, Park SJ, Park DY, Seo HI

PURPOSE: The reflux of pancreatic enzymes into the biliary tract is associated with chronic inflammation and increases cellular proliferation of the biliary epithelium, leading to biliary carcinoma. The aim of...
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Expression of Immunohistochemical Markers before and after Neoadjuvant Chemotherapy in Breast Carcinoma, and Their Use as Predictors of Response

Lee HC, Ko H, Seol H, Noh DY, Han W, Kim TY, Im SA, Park IA

PURPOSE: For patients with breast carcinoma, immunohistochemical markers are important factors in determining the breast cancer subtype and for establishing a therapeutic plan, including the use of neoadjuvant chemotherapy (NACT)....
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Clinical and Histopathological Study of Pheochromocytoma Arising in the Adrenal Gland

Hong SH, Kang GH, Kang DY

  • KMID: 2264199
  • Korean J Med.
  • 2012 Jan;82(1):60-66.
BACKGROUND/AIMS: The diagnosis and prognosis of malignant pheochromocytoma are important. Other than distant metastasis, the pathology is insufficient to diagnose malignant versus benign pheochromocytoma. METHODS: We analyzed 33 pheochromocytoma cases using...
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Minichromosome maintenance 7 protein is a reliable biological marker for human cervical progressive disease

Lobato S, Tafuri A, Fernandes , Caliari MV, Silva MX, Xavier MA, Vago AR

OBJECTIVE: This study focused on comparing the expression levels of p16, Ki-67, and minichromosome maintenance 7 (MCM7) protein in normal and affected cervical epithelium to ascertain the biological significance of...
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p16INK4a, PTEN, E-cadherin, Bcl-2 and Ki-67 Expression in Prostate Cancer: Its Relationship with the Metastatic Potential and Known Prognostic Factors

Park SJ, Sung WJ, Kim MJ

  • KMID: 2277536
  • Korean J Pathol.
  • 2010 Dec;44(6):597-604.
BACKGROUND: At present, adequate prognostic markers for prostate cancer progression are still lacking, in spite of intensive investigation. Accordingly, our study examined the relationship between expression of candidate biomarkers and...
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Clinical Significance of PTEN and Ki-67 Expression in Prostate Cancer

Kang I, Kum YS, Park KK, Kim DY, Park JS

PURPOSE: Phosphatase and tensin homolog (PTEN) is a novel tumor suppressor gene located at chromosome 10q23. Ki-67 antigen is a human nuclear protein that is expressed in all active parts...
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The Expressions of E2F1 and p53 in Gastrointestinal Stromal Tumors and Their Prognostic Significance

Kwon MJ, Nam ES, Cho SJ, Park HR, Shin HS, Lee JS, Park CH, Shin WG

  • KMID: 1979338
  • Korean J Pathol.
  • 2009 Jun;43(3):212-220.
BACKGROUND: E2F1 plays a critical role in the G1-to-S phase transition by inducing various genes that encode S phase-activating proteins and that modulate such diverse cellular functions as DNA synthesis,...
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Caveolin-1 and Ki-67 Expression as Prognostic Factors in Clear Cell Carcinoma of the Kidney

Kim BH, Kim CI, Park CH

  • KMID: 2312010
  • Korean J Urol.
  • 2008 Feb;49(2):99-106.
PURPOSE: Caveolin-1 is proposed to represent a novel tumor suppressor protein and expression of recombinant caveolin-1 is sufficient to restrict the growth potential of transformed cells isolated from primary tumors...
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The immunohistochemical study on Ki-67 Expression in epithelial ovarian carcinomas

Park CM, Han SY, Kim I, Kim HC, Kang JS

  • KMID: 2273524
  • Korean J Obstet Gynecol.
  • 2008 Nov;51(11):1288-1294.
OBJECTIVE: The study was to evaluate the biological significance of Ki-67 expression in common epithelial ovarian carcinomas. We investigated the correlation between Ki-67 expression and clinicopathological parameters. METHODS: One hundred patients...
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