- Treatment of Partial-Thickness Burn Wounds with Combined Advanced Therapies: Cultured Allogenic Keratinocyte and Epidermal Growth Factor
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Lee KD, Cha EC, Lee J, Kang SY, Burm JS, Cho J
- KMID: 2540017
- J Wound Manag Res.
- 2023 Feb;19(1):38-45.
- doi: 10.22467/jwmr.2022.02187
Background: Cultured allogenic keratinocyte (CAK) and epidermal growth factor (EGF) are commonly used biological treatments for partial-thickness burn wounds. A comparative study was conducted on whether the combination therapy of... -
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- Expression of Antioxidant Response and Autophagy Markers in Patients with Vitiligo: An Immunohistochemical Study
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Hong EJ, Yoon HJ, Kwon R, Park YL, Lee SH, Lee S
- KMID: 2539541
- Korean J Dermatol.
- 2023 Feb;61(2):79-85.
Background: Oxidative stress is generally accepted as one of the principal pathogenesis of vitiligo, and keratinocyte-melanocyte interactions are also thought to play critical roles. It is well-known that antioxidant response... -
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- Growth Factors Upregulated by Uric Acid Affect Guanine Deaminase-Induced Melanogenesis
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Kim NH, Lee AY
- KMID: 2537585
- Biomol Ther.
- 2023 Jan;31(1):89-96.
- doi: 10.4062/biomolther.2022.137
Uric acid produced by guanine deaminase (GDA) is involved in photoaging and hyperpigmentation. Reactive oxygen species (ROS) generated by uric acid plays a role in photoaging. However, the mechanism by... -
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- Effect of Activating Transcription Factor 3 on Inflammatory Response and Differentiation of Keratinocytes
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Kim K, Kim D, Shin JM, Hong D, Jung KE, Seo YJ, Lee Y, Kim CD
- KMID: 2538560
- Korean J Dermatol.
- 2022 Dec;60(10):640-646.
Background: Pathogenesis of psoriasis is related to dysregulated keratinocyte function and immune responses. Genetic background is one of the most important factors in disease pathogenesis. However, psoriasis-associated genes have not... -
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- Screening of Plant-Derived Natural Extracts to Identify a Candidate Extract Capable of Enhancing Lipid Synthesis in Keratinocytes
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Lee SH, Seo HS, Seo SJ, Kim CD, Hong SP
- KMID: 2533605
- Ann Dermatol.
- 2022 Oct;34(5):331-339.
- doi: 10.5021/ad.21.288
Background: Reduced lipid content in the stratum corneum is a major cause of skin-barrier dysfunction in various pathological conditions. Promoting lipid production is a potential strategy to improve skin-barrier function.... -
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- The Role of Adiponectin in the Skin
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Oh J, Lee Y, Oh SW, Li T, Shin J, Park SH, Lee J
- KMID: 2529887
- Biomol Ther.
- 2022 May;30(3):221-231.
- doi: 10.4062/biomolther.2021.089
Adiponectin (Ad), a 30 kDa molecule, is an anti-diabetic adipokine; although derived from adipose tissue, it performs numerous activities in various other tissues. It binds to its own receptors, namely... -
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- Bitter taste receptors protect against skin aging by inhibiting cellular senescence and enhancing wound healing
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Chung MG, Kim Y, Cha YK, Park TH, Kim Y
- KMID: 2525510
- Nutr Res Pract.
- 2022 Feb;16(1):1-13.
- doi: 10.4162/nrp.2022.16.1.1
BACKGROUND/OBJECTIVES: Bitter taste receptors are taste signaling pathway mediators, and are also expressed and function in extra-gustatory organs. Skin aging affects the quality of life and may lead to medical... -
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- Usefulness of Kaloderm® in Finger Tip Necrosis : A Case Report
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Yoon CM, Lee SC, Choi JA
- KMID: 2524657
- Kosin Med J.
- 2021 Dec;36(2):144-147.
- doi: 10.7180/kmj.2021.36.2.144
We experienced a case of crush injury of the hand for which we performed a flap surgery and treated the necrotic parts placement using cultured allogeneic keratinocytes (Kaloderm® ) with... -
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- NaHCO 3- and NaCl-Type Hot Springs Enhance the Secretion of Inflammatory Cytokine Induced by Polyinosinic-Polycytidylic Acid in HaCaT Cells
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Park SH, Jung BY, Lee SY, Yu DS, Woo SY, Yun ST, Lee JT, Kim JW, Lee YB
- KMID: 2519929
- Ann Dermatol.
- 2021 Oct;33(5):440-447.
- doi: 10.5021/ad.2021.33.5.440
Background: Hot springs have been traditionally used as an alternative treatment for a wide range of diseases, including rheumatoid arthritis, bronchial asthma, diabetes, hypertension, psoriasis and atopic dermatitis. However, the... -
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- Potential Role of Cytosolic RNA Sensor MDA5 as an Inhibitor for Keratinocyte Differentiation in the Pathogenesis of Psoriasis
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Hong DK, Choi MR, Hwang YL, Lee JK, Lee Y, Seo YJ, Kim S, Lee YH, Kim CD, Lee JH
- KMID: 2517840
- Ann Dermatol.
- 2021 Aug;33(4):339-344.
- doi: 10.5021/ad.2021.33.4.339
Background: Psoriasis is a chronic inflammatory skin disease. The etiology of psoriasis is not fully understood, but the genetic background is considered to be the most important factor. To date,... -
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- Keratinocyte-Like Cells Trans-Differentiated from Human Adipose-Derived Stem Cells, Facilitate Skin Wound Healing in Mice
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Kim J, Hasegawa T, Wada A, Maeda Y, Ikeda S
- KMID: 2517838
- Ann Dermatol.
- 2021 Aug;33(4):324-332.
- doi: 10.5021/ad.2021.33.4.324
Background: Mesenchymal stem cells (MSCs) have been reported to promote wound healing in both animal models and human studies. Among MSCs, adipose-derived stem cells (ADSCs) can be easily harvested in... -
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- Expression of neurotransmitter receptors in oral keratinocytes and their response to agonists
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Choi EJ, Chang SH, Choi SY, Choi Y
- KMID: 2514828
- Int J Oral Biol.
- 2021 Mar;46(1):39-44.
- doi: 10.11620/IJOB.2021.46.1.39
This study aimed to investigate whether neurotransmitter receptors in the nervous system were also expressed in oral keratinocytes. Expressions of various neurotransmitter receptor genes in immortalized mouse oral keratinocyte (IMOK)... -
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- Particulate Matters Induce Apoptosis in Human Hair Follicular Keratinocytes
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Jun MS, Kwack MH, Kim MK, Kim JC, Sung YK
- KMID: 2506990
- Ann Dermatol.
- 2020 Oct;32(5):388-394.
- doi: 10.5021/ad.2020.32.5.388
Background: Particulate matters (PM) comprise a heterogeneous mixture of particles suspended in air. A recent study found that urban PMs may penetrate into hair follicles via transfollicular and transdermal routes... -
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- Epigenetic Regulation of Filaggrin Gene Expression in Human Epidermal Keratinocytes
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Lee J, Jang A, Seo SJ, Myung SC
- KMID: 2471338
- Ann Dermatol.
- 2020 Apr;32(2):122-129.
- doi: 10.5021/ad.2020.32.2.122
BACKGROUND: Loss-of-function mutations in the filaggrin gene (FLG), which encodes an epidermal protein crucial for the formation of a functional skin barrier, have been identified as a major predisposing factor... -
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- Feasibility of Cultured Allogenic Keratinocyte Treatment for Third Degree Burns
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Choi J, Cho JT, Choi JY, Seo BF, Jung SN
- KMID: 2469248
- J Korean Burn Soc.
- 2019 Dec;22(2):45-48.
- doi: 10.0000/jkbs.2019.22.2.45
Allogenic keratinocyte application is widely used for treatment of second degree burns. However, there is no significant body of report on application of allogenic keratinocyte to third degree burns. A... -
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- Wound Healing Potential of Low Temperature Plasma in Human Primary Epidermal Keratinocytes
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Cui HS, Cho YS, Joo SY, Mun CH, Seo CH, Kim JB
- KMID: 2467051
- Tissue Eng Regen Med.
- 2019 Dec;16(6):585-593.
- doi: 10.1007/s13770-019-00215-w
BACKGROUND: Low temperature plasma (LTP) was recently shown to be potentially useful for biomedical applications such as bleeding cessation, cancer treatment, and wound healing, among others. Keratinocytes are a major... -
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- A Novel Effect of Lipids Extracted from Vernix Caseosa on Regulation of Filaggrin Expression in Human Epidermal Keratinocytes
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Qiao W, Jia T, Gu H, Guo R, Kaku K, Wu W
- KMID: 2461983
- Ann Dermatol.
- 2019 Dec;31(6):611-620.
- doi: 10.5021/ad.2019.31.6.611
BACKGROUND: Vernix caseosa (VC), which is known as a unique human substance, is a biofilm that covers the skin of most human newborns. VC has many biological functions including anti-infective,... -
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- Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter
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Zhen AX, Piao MJ, Kang KA, Madushan Fernando PDS, Kang HK, Koh YS, Yi JM, Hyun JW
- KMID: 2462883
- Biomol Ther.
- 2019 Nov;27(6):562-569.
- doi: 10.4062/biomolther.2019.061
Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that... -
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- Inhibition of Poly(I:C)-Induced Inflammation by Salvianolic Acid A in Skin Keratinocytes
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Zhang QL, Jiang RH, Li XM, Ko JW, Kim CD, Zhu MJ, Lee JH
- KMID: 2444859
- Ann Dermatol.
- 2019 Jun;31(3):279-285.
- doi: 10.5021/ad.2019.31.3.279
BACKGROUND: Skin keratinocytes participate actively in inducing immune responses when external pathogens are introduced, thereby contributing to elimination of pathogens. However, in condition where the excessive inflammation is occurred, chronic... -
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- Adiponectin Attenuates the Inflammation in Atopic Dermatitis-Like Reconstructed Human Epidermis
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Seo HS, Seong KH, Kim CD, Seo SJ, Park BC, Kim MH, Hong SP
- KMID: 2439064
- Ann Dermatol.
- 2019 Apr;31(2):186-195.
- doi: 10.5021/ad.2019.31.2.186
BACKGROUND: Atopic dermatitis (AD) is a chronic disorder, with a vicious cycle of repetitive inflammation and deterioration of the epidermal barrier function. Adiponectin, an adipokine, has anti-inflammatory effects on various... -
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