- Impact of COVID-19 on the End-of-Life Care of Cancer Patients Who Died in a Korean Tertiary Hospital: A Retrospective Study
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Shin J, Kim Y, Yoo SH, Sim JA, Keam B
- KMID: 2536520
- Korean J Hosp Palliat Care.
- 2022 Dec;25(4):150-158.
- doi: 10.14475/jhpc.2022.25.4.150
Purpose: Social distancing and strict visitor restrictions at hospitals have been national policies since the onset of the coronavirus disease 2019 (COVID-19) pandemic. This has challenged the concept of a... -
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- Hospice-Palliative Medicine as a Model of Value-Based Healthcare
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Heo DS, Yoo SH, Keam B, Yoo K, Choi I, Kim MJ
- KMID: 2528171
- J Korean Med Sci.
- 2022 Apr;37(15):e111.
- doi: 10.3346/jkms.2022.37.e111
Advances in medical technology have increased people’s lifespans, and evidence-based medicine that utilizes health technology assessments has contributed significantly to medical development. Owing to the ever-increasing costs of medical services,... -
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- Problems Related to the Act on Decisions on Life-Sustaining Treatment and Directions for Improvement
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Heo DS, Yoo SH, Keam B, Yoo SH, Koh Y
- KMID: 2526939
- Korean J Hosp Palliat Care.
- 2022 Mar;25(1):1-11.
- doi: 10.14475/jhpc.2022.25.1.1
The Act on Decisions on Life-Sustaining Treatment has been in effect since 2018 for endof-life patients. However, only 20~25% of deaths of terminally ill patients comply with the law, while... -
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- Temporal evolution of programmed death-ligand 1 expression in patients with non-small cell lung cancer
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Nam CH, Koh J, Ock CY, Kim M, Keam B, Kim TM, Jeon YK, Kim DW, Chung DH, Heo DS
- KMID: 2517814
- Korean J Intern Med.
- 2021 Jul;36(4):975-984.
- doi: 10.3904/kjim.2020.178
Background/Aims: Programmed death-ligand 1 (PD-L1) expression, a validated predictive biomarker for anti-PD-1/PD-L1 inhibitors, is reported to change over time. This poses challenges during clinical application in non-small cell lung cancer. Methods:... -
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- Outcomes and Biomarkers of Immune Checkpoint Inhibitor Therapy in Patients with Refractory Head and Neck Squamous Cell Carcinoma: KCSG HN18-12
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Lee YG, Chang H, Keam B, Chun SH, Park J, Park KU, Shin SH, An HJ, Lee KE, Lee KW, Kim HR, Kim SB, Ahn MJ, Hwang IG
- KMID: 2518390
- Cancer Res Treat.
- 2021 Jul;53(3):671-677.
- doi: 10.4143/crt.2020.824
Purpose This study was conducted to determine the effectiveness of immune checkpoint inhibitors (ICIs) in recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) after platinum-containing chemotherapy. We... -
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- Practical Considerations in Providing End-of-Life Care for Dying Patients and Their Family in the Era of COVID-19
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Kim Y, Yoo SH, Shin JM, Han HS, Hong J, Kim HJ, Choi W, Kim MS, Park HY, Keam B
- KMID: 2516547
- Korean J Hosp Palliat Care.
- 2021 Jun;24(2):130-134.
- doi: 10.14475/jhpc.2021.24.2.130
In the era of coronavirus disease 2019 (COVID-19), social distancing and strict visitation policies at hospitals have made it difficult for medical staff to provide high-quality endof-life (EOL) care to... -
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- Difficulties Doctors Experience during Life-Sustaining Treatment Discussion after Enactment of the Life-Sustaining Treatment Decisions Act: A Cross-Sectional Study
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Yoo SH, Choi W, Kim Y, Kim MS, Park HY, Keam B, Heo DS
- KMID: 2514939
- Cancer Res Treat.
- 2021 Apr;53(2):584-592.
- doi: 10.4143/crt.2020.735
Purpose This study aimed to investigate difficulties doctors experience during life-sustaining treatment (LST) discussion with seriously ill patients and their families after enactment of the LST Decisions Act in February... -
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- Genotypic and Phenotypic Characteristics of Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome in Korean Patients
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Seo JY, Ahn JY, Keam B, Kim M, Yoon S, Lee JL, Park K, Park I
- KMID: 2512667
- Ann Lab Med.
- 2021 Mar;41(2):207-213.
- doi: 10.3343/alm.2021.41.2.207
Background: Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an autosomal dominant cancer predisposition syndrome. HLRCC is characterized by the development of cutaneous leiomyomas, early-onset uterine leiomyomas, and HLRCC-associated renal... -
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- Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma
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Ha H, Keam B, Ock CY, Kim TM, Kim JH, Chung EJ, Kwon SK, Ahn SH, Wu HG, Sung MW, Heo DS
- KMID: 2509771
- Korean J Intern Med.
- 2021 Jan;36(1):175-181.
- doi: 10.3904/kjim.2019.104
Background/Aims Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor characterized by indolence, with a high rate of local recurrence and distant metastasis. This study aimed to investigate the effect... -
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- Barriers to Counseling on Advance Directives Based on Counselors’ Experiences: Focus Group Interviews
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Kim Y, Yoo SH, Choi W, Kim MS, Park HY, Keam B
- KMID: 2506079
- Korean J Hosp Palliat Care.
- 2020 Sep;23(3):126-138.
- doi: 10.14475/kjhpc.2020.23.3.126
Purpose: In Korea, since the Act on Hospice and Palliative Care and Decisions on LifeSustaining Treatment for Patients at the End of Life was implemented in February 2018, advance directives... -
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- Squamous cell carcinoma of head and neck: what internists should know
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Jung K, Narwal M, Min SY, Keam B, Kang H
- KMID: 2505575
- Korean J Intern Med.
- 2020 Sep;35(5):1031-1044.
- doi: 10.3904/kjim.2020.078
Squamous cell carcinoma of head and neck (SCCHN) is a group of cancer arising from mucosal surfaces of the head and neck. Optimal management of SCCHN requires a multidisciplinary team... -
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- Implication of the Life-Sustaining Treatment Decisions Act on End-of-Life Care for Korean Terminal Patients
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Kim JS, Yoo SH, Choi W, Kim Y, Hong J, Kim MS, Park HY, Keam B, Heo DS
- KMID: 2504470
- Cancer Res Treat.
- 2020 Jul;52(3):917-924.
- doi: 10.4143/crt.2019.740
Purpose Life-sustaining treatment (LST) decisions for patients and caregivers at the end-of-life (EOL) process are supported by the “Act on Hospice and Palliative Care and Decisions on LST for Patients at... -
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- Failure patterns of cervical lymph nodes in metastases of unknown origin according to target volume
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Kim DY, Heo DS, Keam B, Ock CY, Ahn SH, Kim Jh, Jung KC, Kim JH, Wu HG
- KMID: 2501449
- Radiat Oncol J.
- 2020 Mar;38(1):18-25.
- doi: 10.3857/roj.2020.00108
Purpose: This study was aim to evaluate the patterns of failure according to radiotherapy (RT) target volume for cervical lymph nodes in metastases of unknown primary origin in head and... -
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- Poor prognostic factors in human papillomavirus-positive head and neck cancer: who might not be candidates for de-escalation treatment?
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Yoo SH, Ock CY, Keam B, Park SJ, Kim TM, Kim JH, Jeon YK, Chung EJ, Kwon SK, Hah JH, Kwon TK, Jung KC, Kim DW, Wu HG, Sung MW, Heo DS
- KMID: 2463490
- Korean J Intern Med.
- 2019 Nov;34(6):1313-1323.
- doi: 10.3904/kjim.2017.397
BACKGROUND/AIMS: Since patients with human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) have favorable outcomes after treatment, treatment de-escalation for these patients is being actively investigated. However, not... -
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- Bevacizumab Plus Erlotinib Combination Therapy for Advanced Hereditary Leiomyomatosis and Renal Cell Carcinoma-Associated Renal Cell Carcinoma: A Multicenter Retrospective Analysis in Korean Patients
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Choi Y, Keam B, Kim M, Yoon S, Kim D, Choi JG, Seo JY, Park I, Lee JL
- KMID: 2460603
- Cancer Res Treat.
- 2019 Oct;51(4):1549-1556.
- doi: 10.4143/crt.2019.086
PURPOSE: Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a rare genetic syndrome resulting from germline mutations in fumarate hydratase. The combination of bevacizumab plus erlotinib showed promising interim results... -
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- The Prognostic Value of Albumin-to-Alkaline Phosphatase Ratio before Radical Radiotherapy in Patients with Non-metastatic Nasopharyngeal Carcinoma: A Propensity Score Matching Analysis
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Kim JS, Keam B, Heo DS, Han DH, Rhee CS, Kim JH, Jung KC, Wu HG
- KMID: 2460581
- Cancer Res Treat.
- 2019 Oct;51(4):1313-1323.
- doi: 10.4143/crt.2018.503
PURPOSE: We first analyzed the prognostic power of albumin-to-alkaline phosphatase ratio (AAPR) before radical radiotherapy (RT) in non-metastatic nasopharyngeal carcinoma (NPC) patients. MATERIALS AND METHODS: The records of 170 patients with... -
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- Clinical factors affecting progression-free survival with crizotinib in ALK-positive non-small cell lung cancer
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Ock CY, Yoo SH, Keam B, Kim M, Kim TM, Jeon YK, Kim DW, Chung DH, Heo DS
- KMID: 2457035
- Korean J Intern Med.
- 2019 Sep;34(5):1116-1124.
- doi: 10.3904/kjim.2018.011
BACKGROUND/AIMS: Although crizotinib is standard chemotherapy for advanced anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC), clinical factors affecting progression-free survival (PFS) have not been reported. The purpose of... -
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- Costs and clinical outcomes of patients with diffuse large B-cell lymphoma in first remission: role of PET/CT surveillance
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Suh KJ, Kim KH, Kim R, Byun JM, Kim M, Park JH, Keam B, Kim TM, Kim JS, Choi IS, Heo DS
- KMID: 2457320
- Korean J Intern Med.
- 2019 Jul;34(4):894-901.
- doi: 10.3904/kjim.2017.174
BACKGROUND/AIMS: The role of [18F]-f luorodeoxyglucose positron emission tomography-computed tomography (PET/CT) in patients with diffuse large B-cell lymphoma (DLBCL) in first remission is unclear. METHODS: Medical costs within the first 3... -
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- Clinical significance of rituximab infusion-related reaction in diffuse large B-cell lymphoma patients receiving R-CHOP
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Cho KM, Keam B, Ha H, Kim M, Jung JW, Song WJ, Kim TM, Jeon YK, Kang HR, Kim DW, Kim CW, Heo DS
- KMID: 2457319
- Korean J Intern Med.
- 2019 Jul;34(4):885-893.
- doi: 10.3904/kjim.2017.036
BACKGROUND/AIMS: This study was to evaluate the clinical significance of infusion-related reaction (IRR) of rituximab in diffuse large B-cell lymphoma (DLBCL) patients who received R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and... -
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- Alterations in PD-L1 Expression Associated with Acquisition of Resistance to ALK Inhibitors in ALK-Rearranged Lung Cancer
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Kim SJ, Kim S, Kim DW, Kim M, Keam B, Kim TM, Lee Y, Koh J, Jeon YK, Heo DS
- KMID: 2454314
- Cancer Res Treat.
- 2019 Jul;51(3):1231-1240.
- doi: 10.4143/crt.2018.486
PURPOSE: The purpose of this study was to evaluate the relationships between the resistance of anaplastic lymphoma kinase (ALK)‒positive non-small cell lung cancer (NSCLC) to ALK inhibitors and the programmed... -
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