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Effect of Serum Perampanel Concentration on Sporadic Amyotrophic Lateral Sclerosis Progression

Kato H, Naito M, Saito T, Hideyama T, Terashi H, Kwak S, Aizawa H

Background and Purpose To clarify the effect of perampanel (PER) on sporadic amyotrophic lateral sclerosis (sALS) progression, the relationship between the changes in Revised Amyotrophic Lateral Sclerosis Functional Rating Scale...
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Comparison of Bilateral and Trisegment Drainage in Patients with High-Grade Hilar Malignant Biliary Obstruction: A Multicenter Retrospective Study

Matsumoto K, Kato H, Morimoto K, Miyamoto K, Saragai Y, Kawamoto H, Okada H

Background/Aims: Bilateral endoscopic drainage with self-expanding metallic stent (SEMS) can be used to effectively manage hilar malignant biliary obstruction. However, the benefits of using a trisegment drainage method remain unknown. Methods:...
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Frequency and clinical features of deficient mismatch repair in ovarian clear cell and endometrioid carcinoma

Tanaka T, Takehara K, Yamashita N, Okazawa-Sakai M, Kuraoka K, Teramoto N, Taguchi K, Yamashiro K, Kato H, Mizunoe T, Suzuki R, Yamamoto D, Ueki A, Saito T

Objective To clarify the frequency of deficient mismatch repair (dMMR) in Japanese ovarian cancer patients, we examined microsatellite instability (MSI) status and immunohistochemistry (IHC) subtypes, including endometrioid carcinoma (EMC), clear cell...
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Prolyl Isomerase Pin1 Expression in the Spinal Motor Neurons of Patients With Sporadic Amyotrophic Lateral Sclerosis

Kato H, Naito M, Tomoko T, Hideyama T, Yasuhiro Y, Kimura T, Kwak S, Hitoshi H

Background and Purpose Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease. Selective deficiency of edited adenosine deaminase acting on RNA 2 (ADAR2), a key molecule in the acquisition...
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Improved Stability and Practicality for Synthesis of 4-Borono-2-[ 18F] fluoro-L-phenylalanine by Combination of [ 18 O]O 2 Single-Use and [ 18 F]CH 3 COOF Labeling Agents

Naka S, Watanabe T, Kanai Y, Watabe T, Tatsumi M, Kato H, Shimosegawa E, Hatazawa J

Purpose 4-Borono-2-[ 18 F]fluoro-L-phenylalanine ([ 18 F]FBPA) synthesized with [ 18 F]F2 , produced using the 18 O(p, n) 18 F reaction, has been reported for increasing radioactivity. However, a...
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Utility of Endoscopic Ultrasound-Guided Fine Needle Aspiration in the Diagnosis of Local Recurrence of Pancreaticobiliary Cancer after Surgical Resection

Matsumoto K, Kato H, Horiguchi S, Tomoda T, Matsumi A, Ishihara Y, Saragai Y, Takada S, Muro S, Uchida D, Okada H

Background/Aims: Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA; EUS-FNA) allows for diagnostic tissue specimens from various regions to be analyzed. How-ever, diagnosing recurrent pancreaticobiliary cancer after surgery is sometimes difficult....
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Magnetic Resonance Imaging Findings Differentiating Cutaneous Basal Cell Carcinoma from Squamous Cell Carcinoma in the Head and Neck Region

Kawaguchi , Kato H, Tomita H, Hara A, Suzui N, Miyazaki T, Matsuyama , Seishima M, Matsuo M

OBJECTIVE: This study aimed to evaluate the efficacy of magnetic resonance (MR) imaging in differentiating between cutaneous basal cell carcinoma (cBCC) and cutaneous squamous cell carcinoma (cSCC) in the head...
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History and Future of Treatment for Acute Stage Kawasaki Disease

Ishii M, Ebato T, Kato H

Kawasaki disease is a form of vasculitis, mainly in small and medium arteries of unknown origin, occurring frequently in childhood. It is the leading form of childhood-onset acquired heart disease...
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Effects of monthly minodronate with or without eldecalcitol addition in osteoporosis patients with rheumatoid arthritis: An 18-month prospective study

Suzuki T, Nakamura Y, Kato H

OBJECTIVES: Increasing bone mineral density (BMD) to reduce fracture risk is a primary goal of osteoporosis treatment. This prospective, observational study evaluates the effects of monthly minodronate (MIN; 50 mg)...
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Ten-Year Results of Reconstruction for Rheumatoid Cervical Spine Lesions and Occurrence Factor of Subaxial Subluxation

Kurogochi , Takahashi , Uehara M, Ikegami S, Kuraishi S, Futatsugi , Oba H, Takizawa T, Munakata R, Hatakenaka T, Koseki M, Kato H

STUDY DESIGN: Retrospective chart review. PURPOSE: This study evaluated long-term surgical outcomes of computer-assisted reconstruction using transarticular or cervical pedicle screws for cervical spine lesions caused by advanced rheumatoid arthritis (RA). OVERVIEW...
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Diagnostic Ability of Convex-Arrayed Endoscopic Ultrasonography for Major Vascular Invasion in Pancreatic Cancer

Fujii Y, Matsumoto , Kato H, Saragai Y, Takada S, Mizukawa S, Muro S, Uchida D, Tomoda T, Horiguchi , Tanaka N, Okada H

BACKGROUND/AIMS: This study aimed to examine the diagnostic ability of endoscopic ultrasonography (EUS) for major vascular invasion in pancreatic cancer and to evaluate the relationship between EUS findings and pathological...
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Endoscopic Ultrasound-Guided Transgastric Drainage of an Intra-Abdominal Abscess following Gastrectomy

Kikuchi S, Kubota T, Kuroda S, Nishizaki , Kagawa S, Kato H, Okada H, Fujiwara T

Endoscopic ultrasound (EUS)-guided transgastric drainage has been performed as a less invasive procedure for pancreatic fistulas and intra-abdominal abscesses occurring after surgery in recent years. However, there are no reports...
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A “Back Light System” for Identification of Sites for Endoscopic Ultrasound-Guided Fine-Needle Aspiration in Solid Pancreatic Masses: A Prospective, Randomized Study with a Crossover Design

Harada R, Kato H, Fushimi S, Inoue H, Uchida D, Akimoto Y, Tomoda T, Matsumoto , Noma Y, Yamamoto N, Horiguchi , Tsutsumi K, Okada H

BACKGROUND/AIMS: We applied a back light system (BLS) with a magnifying glass to improve the ability to assess the adequacy of specimen sampling using endosonography. We conducted this study to...
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Additive effects of eldecalcitol in poorly responding long-term bisphosphonate treatment for osteoporosis

Kamimura M, Ikegami S, Mukaiyama , Koiwai H, Nakamura Y, Taguchi A, Kato H

OBJECTIVES: We examined whether eldecalcitol (ELD) provided additive bone mineral density (BMD) and bone turnover marker gains in patients undergoing long-term bisphosphonate (BP) usage, especially in osteoporotic individuals exhibiting a...
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Impaired Nucleoporins Are Present in Sporadic Amyotrophic Lateral Sclerosis Motor Neurons that Exhibit Mislocalization of the 43-kDa TAR DNA-Binding Protein

Aizawa H, Yamashita , Kato H, Kimura T, Kwak S

BACKGROUND AND PURPOSE: Disruption of nucleoporins has been reported in the motor neurons of patients with sporadic amyotrophic lateral sclerosis (sALS). However, the precise changes in the morphology of nucleoporins...
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Negative peritoneal washing cytology during interval debulking surgery predicts overall survival after neoadjuvant chemotherapy for ovarian cancer

Iura A, Takita M, Kawano A, Imai K, Konnai K, Onose R, Kato H

OBJECTIVE: Optimal debulking in interval debulking surgery (IDS) after neoadjuvant chemotherapy (NAC) has been reported as a prognostic factor for patients with ovarian cancer. However, the identification of microscopic residual...
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Efficacy, safety, and compliance of ibandronate treatment for 3 years in postmenopausal Japanese women with primary osteoporosis

Suzuki T, Nakamura Y, Kato H

OBJECTIVES: The aim of this study was to examine the efficacy, safety, and adherence of ibandronate (IBN) treatment with or without vitamin D supplementation for 3 years in Japanese women...
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Therapeutic significance of full lymphadenectomy in early-stage ovarian clear cell carcinoma

Yamazaki H, Todo Y, Shimada C, Takeshita , Minobe S, Okamoto K, Yamashiro , Kato H

OBJECTIVES: This study evaluated the therapeutic significance of full lymphadenectomy in early-stage ovarian clear cell carcinoma (OCCC). METHODS: We retrospectively reviewed records of 127 consecutive patients with pT1/pT2 and M0 OCCC...
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Fecal microbiota transplantation for recurrent Clostridium difficile infection in a patient with ulcerative colitis

Nanki K, Mizuno S, Matsuoka K, Ono K, Sugimoto S, Kiyohara H, Arai M, Nakashima , Takeshita , Saigusa K, Senoh M, Fukuda T, Naganuma M, Kato H, Suda W, Hattori M, Kanai T

Fecal microbiota transplantation (FMT) has been reported as a safe and effective therapy in patients with refractory and recurrent Clostridium difficile infection (CDI). FMT has also been reported as a...
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Implications of para-aortic lymph node metastasis in patients with endometrial cancer without pelvic lymph node metastasis

Todo Y, Takeshita , Okamoto K, Yamashiro , Kato H

OBJECTIVE: The aim of this study was to confirm the incidence and implications of a lymphatic spread pattern involving para-aortic lymph node (PAN) metastasis in the absence of pelvic lymph...
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