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25 results

Screening and Cloning of Genes Preferentially Expressed in Aminopterin-Treated Myeloma Cell Apoptosis

Lee HC, Kim SJ, Yoon S, Kwon SJ, Chung YH

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):655-664.
PURPOSE: When murine myeloma cells P3-X63-Ag8.653 (V653) of this model treated with amin opterin, an anticancer drug, they can't synthesize nucleic acid via de novo or salvage pathway and selectively eliminated due...
Hematopoietic Recovery of Peripheral Blood Stem Cells Stored at 4degrees C

Cho SG, Oh EJ, Lee JM, Kim HK, Lee KS, Kim CC

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):647-654.
PURPOSE: Cryopreservation has been the standard method of storing hematopoietic cells for the past 20 years, but this prdegrees Cedure is laborious and expensive. So, we evaluated the hematopoietic recovery of stored...
Clinical Significance of Apoptosis and p53 Protein Expression in Stage IIB Squamous Cell Carcinoma of the Cervix Treated with Radiotherapy Alone

Chung EJ, Kim GE, Seong J, Yang WI, Kim YT, Suh CO

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):638-646.
PURPOSE: The purpose was to investigate the spontaneous apoptotic index (SAI) and p53 protein expression and to identify the role of SAI and p53 protein positivity. MATERIALS AND METHODS: Forty six patients...
Matrix Metalloproteinase Expression and Ldegrees Calization in Human Prostate Adendegrees Carcinoma: An Immunohistdegrees Chemical Study of MMP-2, -9, -3, -7

Shim JW, Lee YG, Lee TJ, Ro JY

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):629-637.
No abstract available.
Regulation of Gene Expression in Murine Renal Cell Carcinoma Cells Growing in Ectopic or Orthotopic Organs of Syngenic Mice

Jung YS, Ahn KS, Kim J, Lee H, Yoon SS

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):619-628.
PURPOSE: The biologic behavior of tumor cells is partially controlled by the microenvironment. We investigated the expression levels of several genes involved in metastasis and drug response in RENCA cells growing in...
Efficacy of Combination Chemotherapy with Vinorelbine, Ifosfamide, and Cisplatin in Patients with Advanced Non-Small Cell Lung Cancer

Chang HM, Lee JA, Ahn JS, Woo IS, Park YI, Son JW, Lee SJ, Kim DK, Mo EK, Park MJ, Lee MG, Hyun IG, Jung KS, Park YS

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):612-618.
PURPOSE: To evaluate the efficacy and toxicity of combination chemotherapy with vinorelbine, ifosfamide, and cisplatin in patients with advanced non-small cell lung cancer. MATERIALS AND METHODS: Patients with unresectable, pathologically proven non-small...
Construction of DNA Painting Probe for Transldegrees Cation Region of a Marker Chromosome by Chromosome Microdissection

Park CS, Lee IH, Choi IJ, Kim DK

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):605-611.
PURPOSE: Chromosome microdissection has been recommended as a technology to overcome the limited problems of conventional cytogenetic analysis and is a direct approach to isolate DNA from specific interesting region of chromosome....
Production of Soluble VEGF Receptor Mutants for Inhibition of Angiogenesis

Yun SY, Hong YK, Lee Y, Kim K, Kim HK, Joe YA

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):595-604.
PURPOSE: Vascular endothelial growth factor (VEGF) is a potent angiogenic factor of many solid tumors, promoting vascularization and formation of metastases. In an attempt to generate effective VEGF inhibitors, the authors constructed...
Frequency of bcl-2/JH Rearrangement in Benign Lymphoid Hyperplasia

Yoo YA, Lee SH, Son MN, Cho ZK, Choi K, Choi JW, Shin SW, Kim BS, Kim JS, Kim IS, Kim YH

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):587-594.
No abstract available.
Determination of Chromosomal Alterations in Nasal NK/T-cell Lymphomas by DOP-PCR and Comparative Genomic Hybridization

Park SJ, Ha MJ, Kim HJ, Park KH, Kim HS, Yang WI, Kim HC

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):578-586.
PURPOSE: Because of difficulty of obtaining metaphase cells from tumor specimens, there are only a few cytogenetic studies in nasal NK/T-cell lymphomas, and so far no consistent specific chromosomal abnormalities have been...
Radioresponse of Hepatdegrees Celluar Carcinoma Treatment of Lymph Node Metastasis

Kim JH, Choi EK, Chung YW, Lee YS, Seo DJ

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):571-577.
No abstract available.
Sequential Changes of Proliferative Fraction of Enzyme Altered Fdegrees Ci in Experimental Rat Hepatdegrees Carcinogenesis

Kim WH, Yoo YS, Kim YI, Lee MS, Lee MJ, Jang JJ

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):563-570.
PURPOSE: The proliferative activity of cells in enzyme altered fdegrees Ci of the rat hepatoma model was measured by double immunohistdegrees Chemical staining methods using anti-bromodeoxyuridine (BrdU) and anti-glutathione S transferase of...
Alterations of p15INK4B, p16INK4A and Methylthioadenosine Phosphorylase Gene in Korean Hepatdegrees Cellular Carcinoma

Pyun HY, Cho JW, Baik WK, Park JW, Park JP, Suh MH, Suh SI

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):553-562.
PURPOSE: We analyzed the gene status of p16INK4A, p15INK4B and MTAP (methylthio adenosine phophorylase) in Korean hepatdegrees Cellular carcinoma (HCC) to investigate whether the inactivation of these genes participated in hepatdegrees Carcinogenesis,...
Phase II Multicenter Trial of Paclitaxel for Metastatic Breast Cancer

Byun JH, Yoon SS, Park CH, Kim SR, Kim SY, Kim HJ, Bang SM, Chang HM, Heo DS, Bang YJ, Kim NK

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):545-552.
PURPOSE: To evaluate the efficacy and safety of paclitaxel for metastatic breast cancer patients who had received previous chemotherapy, we have performed phase II multicenter trial between December 1997 and December 1998. MATERIALS...
The Effect of Long-term Tamoxifen Therapy on Endometrium Evaluated by Transvaginal Sonography in Postmenopausal Women Undergone Breast Cancer Surgery

Bae JH, Kim LS, Kim JJ, Lim MK, Kim JH, Woo YM, Park MC, Kim DK, Choi CS, Kim S

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):539-544.
PURPOSE: Tamoxifen is a non-steroidal antiestrogenic drug used mainly in the adjuvant therapy of breast cancer and it also has estrogenic effect to the endometrium. We investigated the effects of tamoxifen on...
The Role of bcl-2 and p53 in Tamoxifen-Induced Apoptosis of Human Breast Cancer Cell Lines

Noh WC, Noh DY, Ham YH, Kim CM, Paik NS, Moon NM, Choe KJ

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):531-538.
PURPOSE: Tamoxifen has been well known as an effective anti-tumor agent against breast cancer. The important role of bcl-2 and p53 proteins in tamoxifen-induced apoptosis of breast cancer cells has been suggested....
Combination Chemotherapy with Etoposide, Doxorubicin, Cisplatin (EAP) for Recurred or Metastatic Gastric

Cancer Refractory to Prior Chemotherapy, Cho NK, Choi TS, Park YH, Lee SC, Yuh YJ, Kim SR

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):524-530.
PURPOSE: We performed this study to evaluate the efficacy and the safety of EAP regimen as a second line therapy for the recurred or metastatic gastric cancer unresponsive to 5-fluorouracil based chemotherapy. MATERIALS...
Chemotherapy with Five-Day Continuous Infusion of 5-Fluorouracil (5-FU) Plus Cisplatin for Advanced Gastric Cancer; Significance of 5-FU Concentration Monitoring

Park YH, Kim BS, Ryoo BY, Kim TY, Im YH, Shin HS, Kang YK

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):516-523.
PURPOSE: To investigate the therapeutic effects and toxicities of 5-day continuous infusion of 5-FU plus cisplatin FP chemotherapy in advanced gastric adendegrees Carcinoma and to elucidate the relationship between the pharmacokinetic (PK)...
Retrospective Analysis of Treatment Results of Recurrent Gastric Cancer

Lee HJ, Cho SJ, Yang HK, Lee KU, Choe KJ, Kim JP

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):506-515.
PURPOSE: Recurrent gastric cancer has a very poor prognosis due to its diagnostic difficulties, variant recurrence patterns and no effective treatment modalities. In this study, we retrospectively analyzed treatment results of the...
Interrelation between the Progression of Gastric Adendegrees Carcinoma and the Matrix Metalloproteinases

Lim SC, Lee MJ, Park CK

  • J Korean Cancer Assoc.
  • 2000 Jun;32(3):497-505.
PURPOSE: An essential element in tumor invasion and metastasis in the degradation of extracellular matrix is matrix metalloproteinases (MMPs). But little is known about the role of them in the gastric adendegrees...

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