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Quantification of Esophageal Angulation in Sigmoid Achalasia: Are We There Yet?

Nabi Z, Reddy DN

  • KMID: 2507121
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):550-551.
  • doi: 10.5056/jnm20084
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Transient Anal Sphincter Relaxations Are a Normal Phenomenon in Healthy Subjects: Author‘s Reply

Lee TH

  • KMID: 2507123
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):554-555.
  • doi: 10.5056/jnm20195
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Is Gastroesophageal Reflux Disease Really a Risk Factor for Acute Myocardial Infarction?

Kim SY

  • KMID: 2507106
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):421-422.
  • doi: 10.5056/jnm20192
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Transient Anal Sphincter Relaxations Are a Normal Phenomenon in Healthy Subjects

Huizinga JD, Milkova N, Chen JH

  • KMID: 2507122
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):552-553.
  • doi: 10.5056/jnm20142
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Whether the Role of Esophageal Baseline Impedance Is Complementary to or Alternative to the 24-Hour Esophageal pH Monitoring for the Diagnosis of Gastroesophageal Reflux Disease?

Cho YK

  • KMID: 2507105
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):419-420.
  • doi: 10.5056/jnm20207
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Calcium/Calmodulin-dependent Serine Protein Kinase-associated Neuro-gastrointestinal Disorder: First Report of a Patient With Hirschsprung‘s Disease

Tian M, Pan H, Lei W, Chen J, Li J, Lang C, Shu X

  • KMID: 2507124
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):556-558.
  • doi: 10.5056/jnm20059
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Esophageal Involvement and Determinants of Perception of Esophageal Symptoms Among South Koreans With Systemic Sclerosis

Lee JS, Kim HS, Moon JR, Ryu T, Hong SJ, Cho YS, Park J, Lee TH

  • KMID: 2507113
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):477-485.
  • doi: 10.5056/jnm19148
Background/Aims Our study aims to characterize esophageal motor function; evaluate the relationships among esophagogastroduodenoscopy (EGD), high-resolution manometry (HRM), and 24-hour esophageal multichannel intraluminal impedance monitoring combined with pHmetry (MII-pH); and elucidate...
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Clinical Evaluation of a Patient With Symptoms of Colonic or Anorectal Motility Disorders

Curtin B, Jimenez E, S CRao S

  • KMID: 2507107
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):423-436.
  • doi: 10.5056/jnm20012
Constipation, irritable bowel syndrome, fecal incontinence, abdominal pain, and anorectal pain are problems that affect 40% of the population. They commonly present with overlapping symptoms indicating that their pathophysiology affects...
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CSP01, a Novel Superabsorbent Hydrogel, Reduces Colonic Transit Time in Patients With Chronic Idiopathic Constipation in a Randomized, Double-blind, Controlled Pilot Clinical Trial

Staller K, Barshop K, Vélez C, Bailey A, Locascio JJ, Chiquette E, Kuo B

  • KMID: 2507115
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):496-504.
  • doi: 10.5056/jnm20001
Background/Aims CSP01 is a novel superabsorbent hydrogel that absorbs gastrointestinal fluids and maintains high viscoelastic properties into the colon, where these fluids are released. Methods We conducted a single-center, randomized, double-blind, parallel-group, placebo-controlled...
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High-resolution Manometry Determinants of Refractoriness of Reflux Symptoms to Proton Pump Inhibitor Therapy

Ribolsi M, Savarino E, Rogers B, Rengarajan A, Coletta MD, Ghisa M, Cicala M, Gyawali CP

  • KMID: 2507109
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):447-454.
  • doi: 10.5056/jnm19153
Background/Aims Impaired esophageal motility and disrupted esophagogastric junction (EGJ) on high-resolution manometry (HRM) have been associated with increased reflux severity in gastroesophageal reflux disease (GERD) patients. However, there are limited data...
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Fecal Microbiota Alterations and Small Intestinal Bacterial Overgrowth in Functional Abdominal Bloating/Distention

Noh CK, Lee KJ

  • KMID: 2507120
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):539-549.
  • doi: 10.5056/jnm20080
Background/Aims The pathophysiology of functional abdominal bloating and distention (FABD) is unclear yet. Our aim is to compare the diversity and composition of fecal microbiota in patients with FABD and healthy...
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The Role of Intestinal Microbiota and Mast Cell in a Rat Model of Visceral Hypersensitivity

Li YJ, Li J, Dai C

  • KMID: 2507119
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):529-538.
  • doi: 10.5056/jnm20004
Background/Aims To explore the role of intestinal flora and mast cells in visceral hypersensitivity (VH). Methods The experimental animals were divided into 4 groups: control group, VH group, VH + VSL#3 group, and...
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The Usefulness of Esophageal Baseline Impedance Levels for the Diagnosis of Nonerosive Reflux Disease and the Proper Time for Measurement in Endoscopy-negative Korean Patients With Esophageal or Supraesophageal Symptoms

Kim YG, Noh CK, Lee KJ

  • KMID: 2507110
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):463-470.
  • doi: 10.5056/jnm20019
Background/Aims Low baseline impedance levels (BILs) have been suggested to be evidence of GERD. The aim of this study is to investigate the usefulness of esophageal BILs for the diagnosis of...
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Transient Receptor Potential Canonical 4 and 5 Channel Antagonist ML204 Depolarized Pacemaker Potentials of Interstitial Cells of Cajal

Lee JH, Wu WH, Huang XY, Jun JY, Choi S

  • KMID: 2507118
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):521-528.
  • doi: 10.5056/jnm20064
Background/Aims To investigate an effect of ML204 (an inhibitor of transient receptor potential canonical 4 and 5 [TRPC4/5] channels) on interstitial cells of Cajal (ICCs) and therefore determine whether TRPC4/5 channels...
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Nutrient Challenge Testing Is Not Equivalent to Scintigraphy−Lactulose Hydrogen Breath Testing in Diagnosing Small Intestinal Bacterial Overgrowth

Schindler V, Huellner M, Murray F, Schnurre L, Becker AS, Bordier V, Pohl D

  • KMID: 2507117
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):514-520.
  • doi: 10.5056/jnm19162
Background/Aims Small intestinal bacterial overgrowth (SIBO) is a common condition in disorders of gut-brain interaction (DGBI). Recently, a combined scintigraphy–lactulose hydrogen breath test (ScLHBT) was described as an accurate tool diagnosing...
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Esophageal Baseline Impedance From High-resolution Impedance Manometry Correlates With Mean Nocturnal Baseline Impedance From pH-impedance Monitoring

Horton A, Sullivan B, Charles K, McIntosh T, Davis A, Gellad Z, Shimpi R, Gyawali CP, Patel A

  • KMID: 2507111
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):455-462.
  • doi: 10.5056/jnm19142
Background/Aims Esophageal baseline impedance (BI) can be extracted from pH-impedance tracings as mean nocturnal baseline impedance (MNBI), and from high-resolution impedance manometry (HRIM), but it is unknown if values are similar...
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The Risk of Acute Myocardial Infarction in Patients With Gastroesophageal Reflux Disease

Eisa M, Sandhu A, Prakash R, Ganocy SJ, Fass R

  • KMID: 2507112
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):471-476.
  • doi: 10.5056/jnm19192
Background/Aims A number of inflammatory mediators have been documented to be elevated in gastroesophageal reflux disease (GERD). Similar inflammatory mediators are involved in coronary artery disease. Thus, the aim of the...
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Effects of a Psychobiotic Supplement on Serum Brain-derived Neurotrophic Factor Levels in Depressive Patients: A Post Hoc Analysis of a Randomized Clinical Trial

Heidarzadeh-Rad N, Gökmen-Özel H, Kazemi A, Almasi N, Djafarian K

  • KMID: 2507114
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):486-495.
  • doi: 10.5056/jnm20079
Background/Aims Psychobiotics are probiotics or prebiotics that, upon ingestion in adequate amounts, yield positive influence on mental health via microbiota-gut-brain axis regulation to modulate the circulating cytokines, chemokines, neurotransmitters, or neurotrophins...
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Depression and Structural Factors Are Associated With Symptoms in Patients of Irritable Bowel Syndrome With Diarrhea

Lu J, Shi L, Huang D, Fan W, Li X, Zhu L, Wei J, Fang X

  • KMID: 2507116
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):505-513.
  • doi: 10.5056/jnm19166
Background/Aims A strong correlation between depression and irritable bowel syndrome with diarrhea (IBS-D) has been identified. The aim of this study is to identify the correlations among depression, structural factors, gastrointestinal...
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Parental, Perinatal, and Childhood Risk Factors for Development of Irritable Bowel Syndrome: A Systematic Review

Low EXS, Mandhari MNKA, Herndon CC, Loo EXL, Tham EH, Siah KTH

  • KMID: 2507108
  • J Neurogastroenterol Motil.
  • 2020 Oct;26(4):437-446.
  • doi: 10.5056/jnm20109
Background/Aims Adverse early life experiences are associated with the development of stroke, cancer, diabetes, and chronic respiratory and ischemic heart diseases. These negative experiences may also play a role in the...
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