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Do Toll-like Receptors Play a New Role as a Biomarker of Irritable Bowel Syndrome?

Kim HJ

  • KMID: 2422841
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):510-511.
  • doi: 10.5056/jnm18153
No abstract available.
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It Is Time to Meet the Challenges of the Changing Epidemiology of Gastroesophageal Reflux Disease

Kim GH

  • KMID: 2422840
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):507-509.
  • doi: 10.5056/jnm18152
No abstract available.
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To Understand the Modulatory Effect of Probiotics on Irritable Bowel Syndrome

Yuan A, Li P, Wang L, Zhong B, Bai B, Huang X, Kou J

  • KMID: 2422857
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):676-677.
  • doi: 10.5056/jnm18097
No abstract available.
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Overexpression of Stromal Interaction Molecule 1/Store-operated Calcium Entry-associated Regulatory Factor in Interstitial Cells of Cajal in Mouse Jejunum Impairs Pacemaker Activity

Jian-Lin L, Chen NY, Pan SL

  • KMID: 2422858
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):678-680.
  • doi: 10.5056/jnm18066
No abstract available.
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Role of High-affinity Choline Transporter 1 in Colonic Hypermotility in a Rat Model of Irritable Bowel Syndrome

Lin MJ, Yu BP

  • KMID: 2422854
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):643-655.
  • doi: 10.5056/jnm18040
BACKGROUND/AIMS: Irritable bowel syndrome (IBS) is a common disease characterized by intestinal dysmotility, the mechanism of which remains elusive. We aim to determine whether the high-affinity choline transporter 1 (CHT1),...
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Improving High-resolution Impedance Manometry Using Novel Viscous and Super-viscous Substrates in the Supine and Upright Positions: A Pilot Study

Wong U, Person EB, Castell DO, von Rosenvinge E, Raufman JP, Xie G

  • KMID: 2422847
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):570-576.
  • doi: 10.5056/jnm18010
BACKGROUND/AIMS: Swallows with viscous or solid boluses in different body positions alter esophageal manometry patterns. Limitations of previous studies include lack of standardized viscous substrates and the need for chewing...
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Understanding Neurogastroenterology From Neuroimaging Perspective: A Comprehensive Review of Functional and Structural Brain Imaging in Functional Gastrointestinal Disorders

Kano M, Dupont P, Aziz Q, Fukudo S

  • KMID: 2422842
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):512-527.
  • doi: 10.5056/jnm18072
This review provides a comprehensive overview of brain imaging studies of the brain-gut interaction in functional gastrointestinal disorders (FGIDs). Functional neuroimaging studies during gut stimulation have shown enhanced brain responses...
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Pathophysiology of Potassium-competitive Acid Blocker–refractory Gastroesophageal Reflux and the Potential of Potassium-competitive Acid Blocker Test

Masaoka T, Kameyama H, Yamane T, Yamamoto Y, Takeuchi H, Suzuki H, Kitagawa Y, Kanai T

  • KMID: 2422848
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):577-583.
  • doi: 10.5056/jnm18036
BACKGROUND/AIMS: Potassium-competitive acid blockers are expected to be the next generation of drugs for the treatment of diseases caused by gastric acid. In 2015, vonoprazan fumarate, a novel potassium-competitive acid...
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Cultural Factors Influencing Functional Gastrointestinal Disorders in the East

Chuah KH, Mahadeva S

  • KMID: 2422844
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):536-543.
  • doi: 10.5056/jnm18064
Culture forms an integral aspect of environmental factors which influences disease presentation and clinical outcomes in functional gastrointestinal disorders (FGIDs). In this review, the role of culture in FGIDs in...
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Sex-Gender Differences in Irritable Bowel Syndrome

Kim YS, Kim N

  • KMID: 2422845
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):544-558.
  • doi: 10.5056/jnm18082
Because of the sex-gender differences that are shown in a diversity of physiological and psychological factors, it can be speculated that the clinical presentation of symptoms as well as treatment...
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Aloe vera Is Effective and Safe in Short-term Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis

Hong SW, Chun J, Park S, Lee HJ, Im JP, Kim JS

  • KMID: 2422843
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):528-535.
  • doi: 10.5056/jnm18077
BACKGROUND/AIMS: To evaluate the efficacy and safety of Aloe vera (AV) in patients with irritable bowel syndrome (IBS). METHODS: We searched the MEDLINE, EMBASE, and Cochrane databases for studies dated between...
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The Effect of Trimebutine on the Overlap Syndrome Model of Guinea Pigs

Hussain Z, Jung DH, Lee YJ, Park H

  • KMID: 2422856
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):669-675.
  • doi: 10.5056/jnm18049
BACKGROUND/AIMS: Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common gastrointestinal (GI) disorders and these patients frequently overlap. Trimebutine has been known to be effective in controlling FD co-existing...
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The Changing Epidemiology of Gastroesophageal Reflux Disease: Are Patients Getting Younger?

Yamasaki T, Hemond C, Eisa M, Ganocy S, Fass R

  • KMID: 2422846
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):559-569.
  • doi: 10.5056/jnm18140
BACKGROUND/AIMS: Gastroesophageal reflux disease (GERD) is a common disease globally with increasing prevalence and consequently greater burden on the Healthcare system. Traditionally, GERD has been considered a disease of middle-aged...
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Association Between Anxiety and Depression and Gastroesophageal Reflux Disease: Results From a Large Cross-sectional Study

Choi JM, Yang JI, Kang SJ, Han YM, Lee J, Lee C, Chung SJ, Yoon DH, Park B, Kim YS

  • KMID: 2422850
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):593-602.
  • doi: 10.5056/jnm18069
BACKGROUND/AIMS: The different clinical manifestations of gastroesophageal reflux disease (GERD) may be influenced by associated psychological factors. We evaluated the psychological status (anxiety and depression) according to each subtype of...
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Quantitative Analysis of Distribution of the Gastrointestinal Tract Eosinophils in Childhood Functional Abdominal Pain Disorders

Lee EH, Yang HR, Lee HS

  • KMID: 2422852
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):614-627.
  • doi: 10.5056/jnm18050
BACKGROUND/AIMS: Although functional abdominal pain disorders (FAPDs) are common in children, the accurate pathogenesis of FAPDs is not known yet. Micro-inflammation, particularly tissue eosinophilia of gastrointestinal (GI) tract, has been...
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Development and Psychometric Assessment of a Self-evaluation Questionnaire for Gastroesophageal Reflux Disease

Jung HK, Choi MG, Baek MK, Wu JC

  • KMID: 2422849
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):584-592.
  • doi: 10.5056/jnm18085
BACKGROUND/AIMS: There is uncertainty about how to measure outcomes reported by patients in gastroesophageal reflux disease (GERD). This study was conducted to develop an instrument and to determine of the...
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Expression of Toll-like Receptors, Pro-, and Anti-inflammatory Cytokines in Relation to Gut Microbiota in Irritable Bowel Syndrome: The Evidence for Its Micro-organic Basis

Shukla R, Ghoshal U, Ranjan P, Ghoshal UC

  • KMID: 2422853
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):628-642.
  • doi: 10.5056/jnm18130
BACKGROUND/AIMS: A Subset of patients with irritable bowel syndrome (IBS) may have mild inflammation due to immune activation. Toll-like receptors (TLRs) and cytokines may cause intestinal inflammation. We studied their...
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MicroRNA-200a Targets Cannabinoid Receptor 1 and Serotonin Transporter to Increase Visceral Hyperalgesia in Diarrhea-predominant Irritable Bowel Syndrome Rats

Hou Q, Huang Y, Zhang C, Zhu S, Li P, Chen X, Hou Z, Liu F

  • KMID: 2422855
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):656-668.
  • doi: 10.5056/jnm18037
BACKGROUND/AIMS: MicroRNAs (miRNAs) were reported to be responsible for intestinal permeability in diarrhea-predominant irritable bowel syndrome (IBS-D) rats in our previous study. However, whether and how miRNAs regulate visceral hypersensitivity...
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Prevalence and Risk Factors of Functional Dyspepsia in Health Check-up Population: A Nationwide Multicenter Prospective Study

Kim SE, Kim N, Lee JY, Park KS, Shin JE, Nam K, Kim HJ, Song HJ, Joo YE, Myung DS, Seo JH, Jo HJ, Kim SM, Lim SH, Kim HJ, Baik GH, Choi SH, Choi SC

  • KMID: 2422851
  • J Neurogastroenterol Motil.
  • 2018 Oct;24(4):603-613.
  • doi: 10.5056/jnm18068
BACKGROUND/AIMS: Functional dyspepsia (FD) is one of the most common gastrointestinal disorders, and FD imposes social and economic burden worldwide. The aim of this study is to identify the prevalence...
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