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NLRP6 as a Negative Regulator of Innate Immunity

Manzoor Z, Koh YS

Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) play important role in immune responses by regulating nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB), type I interferon and inflammasomes. Nod-like receptor...
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Ethical Guidelines for Use of Experimental Animals in Biomedical Research

Cho A, Seok SH

Increasing concerns on animal welfare, the discussion about the necessity and the ethical acceptability of animal experiments is getting important. In this article, we describe ethical issues between the benefits...
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Molecular Methods for Studying the Human Microbiota

Choi YH, Chung J, Na HS

Vast array of microbes colonize to each anatomical environment of human body. Culture based methods are important in investigating the microbial structure, but they are extremely biased in their evaluation...
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Read-through Mutation in the Coat Protein ORF Suppresses Turnip Yellow Mosaic Virus Subgenomic RNA Accumulation

Shin HI, Cho TJ

We have previously observed that a sequence in coat protein (CP) ORF of Turnip yellow mosaic virus (TYMV) is required for efficient replication of the virus. The sequence was predicted...
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Persister Cells: Survival Strategies under Antimicrobiotic Stress

Choi MJ, Ko KS

Persistence is dormant phenotypic variants of regular cells that are tolerant to antibiotics. The persistent cells did not acquire antibiotic resistance genetically, being produced in response to antibiotic stress. Because...
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Cell Culture-based Influenza Vaccines as Alternatives to Egg-based Vaccines

Lee I, Kim JI, Park MS

Influenza viruses have raised public health concerns by seasonal epidemics and intermittent pandemics. Vaccination is considered as the most effective method for preventing influenza infection in humans. Current influenza vaccines...
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Leptin: A Multifunctional Role as an Immunomodulator in Mycobacterial Lung Disease

Song J, Shin SJ, Kim JS

Leptin is a 16 kDa protein which consists of 167 amino acids. Leptin is considered as one of the adipokines, secreted by white adipocytes, and is the product of the...
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The Genetic Characteristics of Multidrug-resistant Acinetobacter baumannii Coproducing 16S rRNA Methylase armA and Carbapenemase OXA-23

Lim J, Cho HH, Kim S, Kim J, Kwon KC, Park JW, Koo SH

Acinetobacter baumannii is a gram-negative organism reported worldwide as a cause of health-care associated infections. Due to its increasing drug resistance, several studies on coproduction of armA and carbapenemase in...
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Epidemiological Relationship of Enterotoxigenic Escherichia coli and Enteroaggregative E. coli Isolated from Patients with Diarrhea in Seoul

Jin Y, Seung H, Oh Y, Jung J, Jeon S, Lee J, Kim C, Choi S, Chae Y

Of total 1,438 specimens of patients with diarrhea in Seoul, 2011, 217 samples (15%) were found pathogenic Escherichia coli that included 192 strains (89%) of enterotoxigenic E. coli (ETEC) and...
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HIV-1 Tat Protein-dependent Cytotoxicity is Attenated by 15-deoxy-Delta12,14-Prostaglandin J2 in Rat Hippocampal Slices: Involvement of the ERK1/2 Signaling Pathway

Lee EO, Yang JH, Kim JH, Woo SY, Chong YH

15-deoxy-delta12,14 prostaglandin J2 (15d-PGJ2) may hold promise in treatment of the pathologies associated with human immunodeficiency virus (HIV) infection of the central nervous system. However, its precise role and neuroprotective...
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