- Auditory sensitivity of 40 Hz event related potential in the hearing impaired subjects
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Jang CG, Kim YH, Kim IK, Cho JH
- KMID: 1684384
- Korean J Otolaryngol-Head Neck Surg.
- 1991 Dec;34(6):1169-1174.
No abstract available. -
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- Evodiamine Reduces Caffeine-Induced Sleep Disturbances and Excitation in Mice
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Ko YH, Shim KY, Lee SY, Jang CG
- KMID: 2421720
- Biomol Ther.
- 2018 Sep;26(5):432-438.
- doi: 10.4062/biomolther.2017.146
Worldwide, caffeine is among the most commonly used stimulatory substances. Unfortunately, significant caffeine consumption is associated with several adverse effects, ranging from sleep disturbances (including insomnia) to cardiovascular problems. This... -
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- Strain Differences in the Chronic Mild Stress Animal Model of Depression and Anxiety in Mice
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Jung YH, Hong SI, Ma SX, Hwang JY, Kim JS, Lee JH, Seo JY, Lee SY, Jang CG
- KMID: 2380324
- Biomol Ther.
- 2014 Sep;22(5):453-459.
- doi: 10.4062/biomolther.2014.058
Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in mice that resembles some of the symptoms of human depression. In the present study, we used a... -
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- Repeated Morphine Administration Increases TRPV1 mRNA Expression and Autoradiographic Binding at Supraspinal Sites in the Pain Pathway
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Nguyen TL, Nam YS, Lee SY, Jang CG
- KMID: 2530997
- Biomol Ther.
- 2022 Jul;30(4):328-333.
- doi: 10.4062/biomolther.2022.014
Repeated morphine administration induces tolerance to its analgesic effects. A previous study reported that repeated morphine treatment activates transient receptor potential vanilloid type 1 (TRPV1) expression in the sciatic nerve,... -
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- Inhibitory Effects of Eucommia ulmoides Oliv. Bark on Scopolamine-Induced Learning and Memory Deficits in Mice
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Kwon SH, Ma SX, Joo HJ, Lee SY, Jang CG
- KMID: 2170664
- Biomol Ther.
- 2013 Nov;21(6):462-469.
Eucommia ulmoides Oliv. Bark (EUE) is commonly used for the treatment of hypertension, rheumatoid arthritis, lumbago, and ischialgia as well as to promote longevity. In this study, we tested the... -
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- Spontaneous Acute Subdural Hemorrhage in a Patient with a Tick Borne Bunyavirus-Induced Severe Fever with Thrombocytopenia Syndrome
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Yoo J, Oh JW, Jang CG, Moon JH, Kim EH, Chang JH, Kim SH, Kang SG
- KMID: 2378253
- Korean J Neurotrauma.
- 2017 Apr;13(1):57-60.
- doi: 10.13004/kjnt.2017.13.1.57
We report the first case of severe fever with thrombocytopenia syndrome (SFTS) and a spontaneous acute subdural hematoma (SDH) in Korea. A 79-year-old male presented with fever and thrombocytopenia. On... -
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- Quinpirole Increases Melatonin-Augmented Pentobarbital Sleep via Cortical ERK, p38 MAPK, and PKC in Mice
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Hong SI, Kwon SH, Hwang JY, Ma SX, Seo JY, Ko YH, Kim HC, Lee SY, Jang CG
- KMID: 2170522
- Biomol Ther.
- 2016 Mar;24(2):115-122.
- doi: 10.4062/biomolther.2015.097
Sleep, which is an essential part of human life, is modulated by neurotransmitter systems, including gamma-aminobutyric acid (GABA) and dopamine signaling. However, the mechanisms that initiate and maintain sleep remain... -
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- The Anti-Inflammatory Activity of Eucommia ulmoides Oliv. Bark. Involves NF-κB Suppression and Nrf2-Dependent HO-1 Induction in BV-2 Microglial Cells
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Kwon SH, Ma SX, Hwang JY, Ko YH, Seo JY, Lee BR, Lee SY, Jang CG
- KMID: 2164219
- Biomol Ther.
- 2016 May;24(3):268-282.
- doi: 10.4062/biomolther.2015.150
In the present study, we investigated the anti-inflammatory properties of Eucommia ulmoides Oliv. Bark. (EUE) in lipopolysaccharide (LPS)-stimulated microglial BV-2 cells and found that EUE inhibited LPS-mediated up-regulation of pro-inflammatory... -
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- Antineuroinflammatory Effects of 7,3’,4’-Trihydroxyisoflavone in Lipopolysaccharide-Stimulated BV2 Microglial Cells through MAPK and NF-κB Signaling Suppression
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Kim SK, Ko YH, Lee Y, Lee SY, Jang CG
- KMID: 2513480
- Biomol Ther.
- 2021 Mar;29(2):127-134.
- doi: 10.4062/biomolther.2020.093
Neuroinflammation—a common pathological feature of neurodegenerative disorders such as Alzheimer’s disease—is mediated by microglial activation. Thus, inhibiting microglial activation is vital for treating various neurological disorders. 7,3’,4’-Trihydroxyisoflavone (THIF)—a secondary metabolite... -
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- Vaccinium bracteatum Thunb. Exerts Anti-Inflammatory Activity by Inhibiting NF-κB Activation in BV-2 Microglial Cells
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Kwon SH, Ma SX, Ko YH, Seo JY, Lee BR, Lee TH, Kim SY, Lee SY, Jang CG
- KMID: 2351680
- Biomol Ther.
- 2016 Sep;24(5):543-551.
- doi: 10.4062/biomolther.2015.205
This study was designed to evaluate the pharmacological effects of Vaccinium bracteatum Thunb. methanol extract (VBME) on microglial activation and to identify the underlying mechanisms of action of these effects.... -
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- The Memory-Enhancing Effects of Liquiritigenin by Activation of NMDA Receptors and the CREB Signaling Pathway in Mice
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Ko YH, Kwon SH, Hwang JY, Kim KI, Seo JY, Nguyen TL, Lee SY, Kim HC, Jang CG
- KMID: 2429049
- Biomol Ther.
- 2018 Mar;26(2):109-114.
- doi: 10.4062/biomolther.2016.284
Liquiritigenin (LQ) is a flavonoid that can be isolated from Glycyrrhiza radix. It is frequently used as a tranditional oriental medicine herbal treatment for swelling and injury and for detoxification.... -
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- Dependence Potential of Tramadol: Behavioral Pharmacology in Rodents
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Cha HJ, Song MJ, Lee KW, Kim EJ, Kim YH, Lee Y, Seong WK, Hong SI, Jang CG, Yoo HS, Jeong HS
- KMID: 2170599
- Biomol Ther.
- 2014 Nov;22(6):558-562.
- doi: 10.4062/biomolther.2014.064
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance... -
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- 7,8,4′-Trihydroxyisoflavone, a Metabolized Product of Daidzein, Attenuates 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells
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Ko YH, Kim SK, Kwon SH, Seo JY, Lee BR, Kim YJ, Hur KH, Kim SY, Lee SY, Jang CG
- KMID: 2455091
- Biomol Ther.
- 2019 Jul;27(4):363-372.
- doi: 10.4062/biomolther.2018.211
Daidzein isolated from soybean (Glycine max) has been widely studied for its antioxidant and anti-inflammatory activities. However, the protective effects of 7,8,4′-trihydroxyisoflavone (THIF), a major metabolite of daidzein, on 6-hydroxydopamine... -
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- Structure–Activity Relationship and Evaluation of Phenethylamine and Tryptamine Derivatives for Affinity towards 5-Hydroxytryptamine Type 2A Receptor
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Wang S, Zhu A, Paudel S, Jang CG, Lee YS, Kim KM
- KMID: 2539586
- Biomol Ther.
- 2023 Mar;31(2):176-182.
- doi: 10.4062/biomolther.2022.096
Among 14 subtypes of serotonin receptors (5-HTRs), 5-HT 2AR plays important roles in drug addiction and various psychiatric disorders. Agonists for 5-HT 2AR have been classified into three structural groups:... -
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- Abuse Potential of Synthetic Cannabinoids: AM-1248, CB-13, and PB-22
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Hur KH, Ma SX, Lee BR, Ko YH, Seo JY, Ryu HW, Kim HJ, Yoon S, Lee YS, Lee SY, Jang CG
- KMID: 2517156
- Biomol Ther.
- 2021 Jul;29(4):384-391.
- doi: 10.4062/biomolther.2020.212
Currently, the expanding recreational use of synthetic cannabinoids (SCBs) threatens public health. SCBs produce psychoactive effects similar to those of tetrahydrocannabinol, the main component of cannabis, and additionally induce unexpected... -
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- Potential Functional Role of Phenethylamine Derivatives in Inhibiting Dopamine Reuptake: Structure–Activity Relationship
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Kundu D, Zhu A, Kim E, Paudel S, Jang CG, Lee YS, Kim KM
- KMID: 2537587
- Biomol Ther.
- 2023 Jan;31(1):108-115.
- doi: 10.4062/biomolther.2022.047
Numerous psychotropic and addictive substances possess structural features similar to those of β-phenethylamine (β-PEA). In this study, we selected 29 β-PEA derivatives and determined their structure–activity relationship (SAR) to their... -
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- Assessment of the Abuse Liability of Synthetic Cannabinoid Agonists JWH-030, JWH-175, and JWH-176
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Tampus R, Yoon SS, de la Pena JB, Botanas CJ, Kim HJ, Seo JW, Jeong EJ, Jang CG, Cheong JH
- KMID: 2380311
- Biomol Ther.
- 2015 Nov;23(6):590-596.
- doi: 10.4062/biomolther.2015.120
The emergence and use of synthetic cannabinoids have greatly increased in recent years. These substances are easily dispensed over the internet and on the streets. Some synthetic cannabinoids were shown... -
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- The Abuse Potential of α-Piperidinopropiophenone (PIPP) and α-Piperidinopentiothiophenone (PIVT), Two New Synthetic Cathinones with Piperidine Ring Substituent
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Botanas CJ, Yoon SS, de la Peña JB, dela Peña IJ, Kim M, Woo T, Seo JW, Jang CG, Park KT, Lee YH, Lee YS, Kim HJ, Cheong JH
- KMID: 2375031
- Biomol Ther.
- 2017 Mar;25(2):122-129.
- doi: 10.4062/biomolther.2016.241
A diversity of synthetic cathinones has flooded the recreational drug marketplace worldwide. This variety is often a response to legal control actions for one specific compound (e.g. methcathinone) which has... -
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- Evaluation of the Abuse Potential of Novel Amphetamine Derivatives with Modifications on the Amine (NBNA) and Phenyl (EDA, PMEA, 2-APN) Sites
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Custodio R, Botanas CJ, Yoon SS, de la Peña JB, dela Peña IJ, Kim M, Woo T, Seo JW, Jang CG, Kwon YH, Kim NY, Lee YS, Kim HJ, Cheong JH
- KMID: 2395806
- Biomol Ther.
- 2017 Nov;25(6):578-585.
- doi: 10.4062/biomolther.2017.141
Recently, there has been a rise in the number of amphetamine derivatives that serve as substitutes for controlled substances (e.g. amphetamine and methamphetamine) on the global illegal drug market. These... -
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- Four Novel Synthetic Tryptamine Analogs Induce Head-Twitch Responses and Increase 5-HTR2a in the Prefrontal Cortex in Mice
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Abiero A, Ryu IS, Botanas CJ, Custodio RJP, Sayson LV, Kim M, Lee HJ, Kim HJ, Seo JW, Cho MC, Lee KW, Yoo SY, Jang CG, Lee YS, Cheong JH
- KMID: 2507806
- Biomol Ther.
- 2020 Jan;28(1):83-91.
- doi: 10.4062/biomolther.2019.049
Tryptamines are monoamine alkaloids with hallucinogenic properties and are widely abused worldwide. To hasten the regulations of novel substances and predict their abuse potential, we designed and synthesized four novel... -
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