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IPA and its precursors differently modulate the proliferation, differentiation, and integrity of intestinal epithelial cells

Ismael S, Rodrigues C, Santos GM, Castela I, Barreiros-Mota I, Almeida MJ, Calhau C, Faria A, Araújo JR

BACKGROUND/OBJECTIVES: Indole-3-propionic acid (IPA) is a tryptophan-derived microbial metabolite that has been associated with protective effects against inflammatory and metabolic diseases. However, there is a lack of knowledge regarding the...
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Maladaptive Behavior and Gastrointestinal Disorders in Children with Autism Spectrum Disorder

Pusponegoro HD, Ismael S, Sastroasmoro S, Firmansyah A, Vandenplas Y

PURPOSE: Various gastrointestinal factors may contribute to maladaptive behavior in children with autism spectrum disorders (ASD). To determine the association between maladaptive behavior in children with ASD and gastrointestinal symptoms...
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