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Effects of Long-term Thrombin Inhibition (Dabigatran Etexilate) on Spontaneous Thrombolytic Activity during the Progression of Atherosclerosis in ApoE−/−–LDLR−/− Double-Knockout Mice

Sanda T, Yoshimura M, Hyodo K, Ishii H, Yamashita T

Background and Objectives: Atherosclerosis is characterized by a hypercoagulable state, during which coagulation and fibrinolytic factors are activated simultaneously. However, details regarding the thrombolytic pathway in this context remain unknown....
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Takotsubo cardiomyopathy during ambulatory anesthesia for bladder hydrodistension therapy: A case report

Yamashita , Ishii H, Hirota K, Sato M, Tanabe H, Fukuda K

Stress-induced cardiomyopathy, also referred to Takotsubo cardiomyopathy or apical ballooning syndrome presents in perioperative period. We demonstrated a case of Takotsubo cardiomyopathy recognized after general anesthesia for bladder hydrodistension therapy...
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Perspective beyond Cancer Genomics: Bioenergetics of Cancer Stem Cells

Ishii H, Doki Y, Mori M

Although the notion that cancer is a disease caused by genetic and epigenetic alterations is now widely accepted, perhaps more emphasis has been given to the fact that cancer is...
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Risk factors for non-reaching of ileal pouch to the anus in laparoscopic restorative proctocolectomy with handsewn anastomosis for ulcerative colitis

Emoto S, Hata K, Nozawa H, Kawai K, Tanaka T, Nishikawa T, Shuno Y, Sasaki K, Kaneko M, Murono K, Iida Y, Ishii H, Yokoyama Y, Anzai H, Sonoda H, Ishihara S

Background/Aims: Restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis and handsewn anastomosis for ulcerative colitis requires pulling down of the ileal pouch into the pelvis, which can be technically challenging. We...
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Relationship between serum total carbon dioxide concentration and bicarbonate concentration in patients undergoing hemodialysis

Hirai K, Ookawara S, Morino J, Minato S, Kaneko S, Yanai K, Ishii H, Matsuyama M, Kitano T, Shindo M, Miyazawa H, Ito K, Ueda Y, Watano T, Fujino S, Omoto K, Morishita Y

Background: Few studies have investigated the relationship between serum total carbon dioxide (CO2) concentration and bicarbonate ion (HCO3-) concentration in patients undergoing hemodialysis. We determined the agreement and discrepancy between...
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Significance of Stabilometry for Assessing Postoperative Body Sway in Patients with Cervical Myelopathy

Tanishima , Nagashima , Ishii H, Fukata S, Dokai T, Murakami T, Morio Y

STUDY DESIGN: Prospective study. PURPOSE: To examine the changes in body sway using stabilometry in patients who underwent cervical laminoplasty for cervical myelopathy. OVERVIEW OF LITERATURE: Although the patients of cervical myelopathy...
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Approximation of bicarbonate concentration using serum total carbon dioxide concentration in patients with non-dialysis chronic kidney disease

Hirai K, Minato S, Kaneko S, Yanai K, Ishii H, Kitano T, Shindo M, Miyazawa H, Ito K, Ueda Y, Kaku Y, Hoshino T, Watano T, Fujino S, Ookawara S, Omoto K, Morishita

BACKGROUND: We investigated the relationship between serum total carbon dioxide (CO₂) and bicarbonate ion (HCO₃⁻) concentrations in pre-dialysis chronic kidney disease (CKD) patients and devised a formula for predicting low...
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Influence of Diabetes Mellitus on Surgical Outcomes in Patients with Cervical Myelopathy: A Prospective, Multicenter Study

Tanishima , Mihara T, Tanida A, Takeda C, Murata M, Takahashi , Yamane K, Morishita , Morio Y, Ishii H, Fukata S, Nanjo Y, Hamamoto Y, Dokai T, Nagashima

STUDY DESIGN: Multicenter, prospective study. PURPOSE: To investigate the effects of diabetes mellitus (DM) on surgical outcomes in patients with cervical myelopathy. OVERVIEW OF LITERATURE: To date, few studies have investigated the...
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