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Effect of gemigliptin on cardiac ischemia/reperfusion and spontaneous hypertensive rat models

Nam DH, Park J, Park SH, Kim KS, Baek EB

Diabetes is associated with an increased risk of cardiovascular complications. Dipeptidyl peptidase-4 (DPP-IV) inhibitors are used clinically to reduce high blood glucose levels as an antidiabetic agent. However, the effect...
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A Novel Dorsal Slit Approached Non-Ischemic Partial Nephrectomy Method for a Renal Tissue Regeneration in a Mouse Model

Chun SY, Kim DH, Kim JS, Kim HT, Yoo ES, Chung JW, Ha YS, Song PH, Joung YK, Han DK, Chung SK, Kim BS, Kwon TG

BACKGROUND: Kidney ischemia-reperfusion (IR) via laparotomy is a conventional method for kidney surgery in a mouse model. However, IR, an invasive procedure, can cause serious acute and chronic complications through...
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Dual Effect of Hepatic Macrophages on Liver Ischemia and Reperfusion Injury during Liver Transplantation

Lu TF, Yang TH, Zhong CP, Shen C, Lin WW, Gu GX, Xia Q, Xu N

Ischemia-reperfusion injury (IRI) is a major complication in liver transplantation (LT) and it is closely related to the recovery of grafts' function. Researches has verified that both innate and adaptive...
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Hypoxic Preconditioned Mesenchymal Stromal Cell Therapy in a Rat Model of Renal Ischemia-reperfusion Injury: Development of Optimal Protocol to Potentiate Therapeutic Efficacy

Jang MJ, You D, Park JY, Kim K, Aum J, Lee C, Song G, Shin HC, Suh N, Kim YM, Kim CS

Although previous and ongoing clinical studies have used stromal cells during renal ischemia-reperfusion injury (IRI), there is little consensus regarding the optimal protocol. We aimed to optimize the protocol for...
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Beneficial Role of Hydrogen Sulfide in Renal Ischemia Reperfusion Injury in Rats

Choi EK, Park SH, Lim JA, Hong SW, Kwak KH, Park SS, Lim DG, Jung H

PURPOSE: Hydrogen sulfide (H2S) is an endogenous gaseous molecule with important physiological roles. It is synthesized from cysteine by cystathionine γ-lyase (CGL) and cystathionine β-synthase (CBS). The present study examined...
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Kidney transplantation and ischemic conditioning: past, present and future perspectives

Jung H

Kidney transplantation is one of the treatments for the end-stage renal disease for various reasons. Ischemia-reperfusion injury (IRI) is an important mechanism of injury associated with acute rejection, delayed graft...
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Effect of etoricoxib on experimental oxidative testicular ischemia-reperfusion damage in rats induced with torsion-detorsion

Yapanoglu , Ozkaya F, Yilmaz AH, Mammadov R, Cimen FK, Hirik E, Altuner D

Etoricoxib features antioxidant and anti-inflammatory properties concomitantly, suggesting that it may be beneficial in testicular ischemia reperfusion (I/R) damage. Our aim is to investigate the effects of etoricoxib on testicular...
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Neuroprotection of Dexmedetomidine against Cerebral Ischemia-Reperfusion Injury in Rats: Involved in Inhibition of NF-κB and Inflammation Response

Wang L, Liu H, Zhang L, Wang G, Zhang M, Yu Y

Dexmedetomidine is an α2-adrenergic receptor agonist that exhibits a protective effect on ischemia-reperfusion injury of the heart, kidney, and other organs. In the present study, we examined the neuroprotective action...
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Protective Role of Fucoidan in Cerebral Ischemia-Reperfusion Injury through Inhibition of MAPK Signaling Pathway

Che N, Ma Y, Xin Y

Fucoidan has been reported to exhibit various beneficial activities ranging from to antivirus and anticancer properties. However, little information is available about the effects of fucoidan on cerebral ischemia-reperfusion injury...
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Inhibiting Cytochrome C Oxidase Leads to Alleviated Ischemia Reperfusion Injury

Yang Z, Duan Z, Yu T, Xu J, Liu L

BACKGROUND AND OBJECTIVES: The overall purpose of this study was to investigate the role of cytochrome C oxidase (CcO) in preventing ischemia reperfusion-induced cardiac injury through gaseous signaling molecule pathways. MATERIALS...
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AT1 Receptor Modulator Attenuates the Hypercholesterolemia-Induced Impairment of the Myocardial Ischemic Post-Conditioning Benefits

Li YW, Li YM, Hon Y, Wan QL, He RL, Wang ZZ, Zhao CH

BACKGROUND AND OBJECTIVES: Ischemic post-conditioning (PostC) has been demonstrated as a novel strategy to harness nature's protection against myocardial ischemia-reperfusion (I/R). Hypercholesterolemia (HC) has been reported to block the effect...
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Endogenous Agmatine Induced by Ischemic Preconditioning Regulates Ischemic Tolerance Following Cerebral Ischemia

Kim JH, Kim JY, Jung JY, Lee YW, Lee WT, Huh SK, Lee JE

Ischemic preconditioning (IP) is one of the most important endogenous mechanisms that protect the cells against ischemia-reperfusion (I/R) injury. However, the exact molecular mechanisms remain unclear. In this study, we...
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The optimal duration of ischemic preconditioning for renal ischemia-reperfusion injury in mice

Choi HS, Hwang JK, Kim JG, Hwang HS, Lee SJ, Chang YK, Kim JI, Moon IS

PURPOSE: The aim of the present study was to investigate the protective effects of ischemic preconditioning for different periods of time and to elucidate the optimal safe ischemic preconditioning time...
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The Effect of Ischemic Preconditioning on the Expression of Serum Cytokines after 2 Hours Ischemia and Timely Reperfusion in the Hindlimb of Mice

Jin JH, Kim SJ, Seo Y, Kim S

The large volume of reactive oxygen species are generated during reperfusion after transient or post-procedural ischemia, which leads to cell injury. This ischemia-reperfusion (IR) injury may cause local and even...
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Protective Effects of the Nuclear Factor Kappa B Inhibitor Pyrrolidine Dithiocarbamate on Experimental Testicular Torsion and Detorsion Injury

Kabay S, Ozden H, Guven G, Burukoglu , Ustuner MC, Topal F, Gunes HV, Ustuner D, Ozbayer C

Testicular torsion results with the damage of the testis and it is a surgical emergency. Pyrrolidine dithiocarbamate (PDTC) is a low-molecular-weight antioxidant and potent inhibitor of nuclear factor kappa B...
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Effects of Transplantation with Marrow-Derived Mesenchymal Stem Cells Modified with Survivin on Renal Ischemia-Reperfusion Injury in Mice

Yuzeng Q, Weiyang H, Xin G, Qingson Z, Youlin K, Ke R

PURPOSE: To determine whether renal injury induced by ischemia-reperfusion (I/R) could be further improved by mesenchymal stem cells (MSCs) modified with survivin. MATERIALS AND METHODS: Lentiviral vectors were used to introduce...
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Change of peroxisome proliferator-activated receptor gamma expression pattern in the gerbil dentate gyrus after transient global cerebral ischemia

Lee CH, Won MH

Peroxisome proliferator-activated receptor gamma (PPARgamma) has various actions including the regulation of adipocyte differentiation, lipid metabolism and glucose homeostasis. In the present study, we examined the changes of PPARgamma immunoreactivity...
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Effect of milrinone on the inflammatory response and NF-kB activation in renal ischemia-reperfusion injury in mice

Jung HS, Joo JD, Kim DW, In JH, Roh M, Jeong JT, Noh SJ, Choi JW

BACKGROUND: Milrinone increases intracellular adenosine 3',5'-cyclic monophosphate concentration and enhances vascular relaxation. Nuclear factor-kappa B (NF-kB) plays a key role in inflammatory responses during ischemia-reperfusion (I/R) injury. We aimed to...
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Oxytocin Ameliorates Remote Liver Injury Induced by Renal Ischemia-Reperfusion in Rats

Tas Hekimoglu A, Toprak G, Akkoc H, Evliyaoglu O, Ozekinci S, Kelle I

Renal ischemia-reperfusion (IR) causes remote liver damage. Oxytocin has anti-inflammatory and antioxidant effects. The main purpose of this study was to evaluate the protective function of oxytocin (OT) in remote...
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Activation of Akt/protein kinase B mediates the protective effects of mechanical stretching against myocardial ischemia-reperfusion injury

Kim CH, Hao J, Ahn HY, Kim SW

Akt/protein kinase B is a well-known cell survival factor and activated by many stimuli including mechanical stretching. Therefore, we evaluated the cardioprotective effect of a brief mechanical stretching of rat...
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