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Subcutaneous integrin inhibitors may provide more treatment options for patients with moderate-to-severe ulcerative colitis

Yoon H

No abstract available.
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Fecal microbiota transplant via colonoscopy may be preferred due to intraprocedure findings

Cho JM, Pestana L, Pardi R, Pardi DS, Khanna S

No abstract available.
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Stem cell-based therapy for inflammatory bowel disease

Shimizu H, Suzuki K, Watanabe M, Okamoto R

Inflammatory bowel disease (IBD) is an idiopathic, multi-etiological disease characterized by inflammation and mucosal destruction of the gastrointestinal tract. Despite the remarkable advance in immunomodulating therapies, there still remains a...
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A pulmonary nodule in a patient with Crohn's disease

Hokama A, Haranaga S, Sasaki T, Matsumoto , Ohira T, Iraha A, Kinjo T, Nahar S, Fujita J

No abstract available.
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Quantitative histology-based classification system for assessment of the intestinal mucosal histological changes in patients with celiac disease

Das P, Gahlot GP, Singh A, Baloda V, Rawat R, Verma AK, Khanna G, Roy M, George A, Singh A, Nalwa A, Ramteke P, Yadav R, Ahuja V, Sreenivas , Gupta SD, Makharia G

BACKGROUND/AIMS: The existing histological classifications for the interpretation of small intestinal biopsies are based on qualitative parameters with high intraobserver and interobserver variations. We have developed and propose a quantitative...
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Prevalence and risk factors of colorectal cancer in Asia

Wong MC, Ding H, Wang J, Chan PS, Huang J

Globally, colorectal cancer (CRC) is a substantial public health burden, and it is increasingly affecting populations in Asian countries. The overall prevalence of CRC is reported to be low in...
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Evaluation of symptoms and symptom combinations in histamine intolerance

Schnedl WJ, Lackner S, Enko D, Schenk M, Holasek SJ, Mangge H

BACKGROUND/AIMS: Food intolerance/malabsorption, particularly histamine intolerance (HIT), may cause nonspecific functional gastrointestinal and extraintestinal symptoms. We evaluated gastrointestinal and extraintestinal symptoms in patients with HIT. METHODS: In an analysis of outpatients'...
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Adherence to Asacol once daily versus divided regimen for maintenance therapy in ulcerative colitis: a prospective, multicenter, randomized study

Park SK, Park SH, Eun CS, Seo GS, Im JP, Kim TO, Park DI

BACKGROUND/AIMS: A once-daily (OD) regimen of 5-aminosalicylic acid (5-ASA) was easier to comply with than a divided daily (DD) regimen, and that treatment efficacy for ulcerative colitis (UC) was not...
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Endoscopic features of gastrointestinal stromal tumor in the small intestine

Ihara Y, Torisu T, Moriyama T, Umeno J, Hirano A, Okamoto Y, Hori Y, Yamamoto H, Kitazono T, Esaki M

BACKGROUND/AIMS: Gastrointestinal stromal tumor (GIST) is one of the most common types of submucosal tumors (SMTs). Because of GIST's malignant potential, it is crucial to differentiate it from other SMTs....
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Iranian Registry of Crohn's and Colitis: study profile of first nation-wide inflammatory bowel disease registry in Middle East

Malekzadeh MM, Sima A, Alatab S, Sadeghi A, Daryani NE, Adibi P, Maleki I, Vossoughinia H, Fakheri H, Yazdanbod , Taghavi SA, Aghazadeh , Somi MH, Zendedel K, Vahedi H, Malekzadeh R

BACKGROUND/AIMS: A recent study revealed increasing incidence and prevalence of inflammatory bowel disease (IBD) in Iran. The Iranian Registry of Crohn's and Colitis (IRCC) was designed recently to answer the...
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Is stool frequency associated with the richness and community composition of gut microbiota?

Kwon HJ, Lim JH, Kang D, Lim S, Park SJ, Kim JH

BACKGROUND/AIMS: Recently, a number of studies have reported that the gut microbiota could contribute to human conditions, including obesity, inflammation, cancer development, and behavior. We hypothesized that the composition and...
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Ustekinumab is effective in biological refractory Crohn's disease patients–regardless of approval study selection criteria

Saman S, Goetz M, Wendler J, Malek NP, Wehkamp J, Klag T

BACKGROUND/AIMS: Ustekinumab is effective in active Crohn's disease. In a retrospective study, we assessed the clinical outcome in nonresponders to anti-tumor necrosis factor therapy, and/or conventional therapy and/or the α4β7-integrin...
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Real-time data monitoring for ulcerative colitis: patient perception and qualitative analysis

Walsh A, Matini L, Hinds C, Sexton V, Brain O, Keshav S, Geddes J, Goodwin G, Collins G, Travis S, Peters M

BACKGROUND/AIMS: TrueColours ulcerative colitis (TCUC) is a comprehensive web-based program that functions through email, providing direct links to questionnaires. Several similar programs are available, however patient perspectives are unexplored. METHODS: A...
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Efficacy and safety of abrilumab, an α4β7 integrin inhibitor, in Japanese patients with moderate-to-severe ulcerative colitis: a phase II study

Hibi T, Motoya S, Ashida T, Sai S, Sameshima , Nakamura S, Maemoto A, Nii M, Sullivan B, Gasser Jr , Suzuki Y

BACKGROUND/AIMS: Inhibition of α4β7 integrin has been shown to be effective for induction and maintenance therapy in patients with ulcerative colitis (UC). We investigated the effects of varying doses of...
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Association of visceral adiposity and insulin resistance with colorectal adenoma and colorectal cancer

Jung IS, Shin CM, Park SJ, Park YS, Yoon H, Jo HJ, Kim N, Lee DH

BACKGROUND/AIMS: To examine whether visceral adiposity serves as a risk factor for colorectal cancer (CRC) and colorectal adenomas. METHODS: Two hundred healthy subjects, 200 patients with colorectal adenoma, and 151 patients...
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Risk of surgery in patients with stricturing type of Crohn's disease at the initial diagnosis: a single center experience

Maehata Y, Nagata Y, Moriyama T, Matsuno Y, Hirano A, Umeno J, Torisu T, Manabe T, Kitazono T, Esaki M

BACKGROUND/AIMS: It remains uncertain which patients with stricturing-type Crohn's disease (CD) require early small bowel surgery after the initial diagnosis. We aimed to clarify clinical characteristics associated with the intervention...
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Clinical comparison of low-volume agents (oral sulfate solution and sodium picosulfate with magnesium citrate) for bowel preparation: the EASE study

Kim J, Kim HG, Kim KO, Kim HW, Park J, Byeon JS, Hwang SW, Shin HD, Shin JE, Yang HJ, Lee HS, Jung Y, Cho YS, Joo YE, Myung DS, Huh KC, Ahn EM

BACKGROUND/AIMS: This study compared the efficacy, compliance, and safety of bowel preparation between sodium picosulfate with magnesium citrate (SPMC) and oral sulfate solution (OSS). METHODS: A prospective randomized multicenter study was...
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Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn's disease in Asia

Ooi CJ, Hilmi I, Banerjee R, Chuah SW, Ng SC, Wei SC, Makharia G, Pisespongsa P, Chen MH, Ran ZH, Ye BD, Park DI, Ling KL, Ong D, Ahuja V, Goh KL, Sollano J, Lim WC, Leung WK, Ali RA, Wu DC, Ong E, Mustaffa N, Limsrivilai J, Hisamatsu , Yang SK, Ouyang Q, Geary R, De Silva J, Rerknimitr R, Simadibrata M, Abdullah M, Leong RW, on behalf of the Asia Pacific Association of Gastroenterology (APAGE) Working Group on Inflammatory Bowel Disease and Asian Organization for Crohn's and Colitis

The Asia-Pacific Working Group on inflammatory bowel disease (IBD) was established in Cebu, Philippines, under the auspices of the Asian Pacific Association of Gastroenterology with the goal of improving IBD...
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