- Dual Specificity Phosphatase 27 Regulates Pluripotency and Meso-Endodermal Differentiation by Interacting with Transcription Factor CP2 Like-1 in Embryonic Stem Cells
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Song S, Heo J, Lee S, Nam YJ, Kim Y, Ju H, Kwon H, Im HJ, Ha SW, Kim HJ, Lee D, Park SJ, Song SH, Park J, Jeong EM, Kim K, Shin DM, Lee S
- KMID: 2574565
- Int J Stem Cells.
- 2025 Nov;18(4):412-425.
- doi: 10.15283/ijsc25047
Transcription factor CP2-like protein 1 (Tfcp2l1), a naïve pluripotency transcription factor, is expressed in both early embryonic and adult tissues, where it enforces pluripotency of embryonic stem cells (ESCs) and... -
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- Stem Cell-Derived Embryo Models: Potential Platforms for Investigating Early Development and Embryotoxicity
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Lee Y, Do JT
- KMID: 2574560
- Int J Stem Cells.
- 2025 Nov;18(4):338-356.
- doi: 10.15283/ijsc25078
Stem cell-derived embryo models (SCDEMs) create opportunities to investigate the morphological dynamics and underlying mechanisms of embryonic development, implantation, and post-implantation progression by recapitulating preand peri-implantation stages in vitro—an area... -
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- Temporal Regulation of Cytokines and Growth Factors for Optimized Hematopoietic-Lineage Specification from Human Pluripotent Stem Cells
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Park J, Koh H, Jeon E, Uh K, Kim S, Lee JH
- KMID: 2574563
- Int J Stem Cells.
- 2025 Nov;18(4):384-400.
- doi: 10.15283/ijsc25020
Human pluripotent stem cells (hPSCs) can be used to investigate hematopoietic development and have the potential to advance cell-based therapies and to facilitate developmental biology studies. However, efficient ex vivo... -
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- Stem Cell R&D in Korea: Yesterday, Today, and Tomorrow — A Paradigm Shift from Therapeutics to Bio-Platforms
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Kim MW, Do JT, Chang YS
- KMID: 2574558
- Int J Stem Cells.
- 2025 Nov;18(4):321-323.
- doi: 10.15283/ijsc25111
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- The Generation of an Induced Pluripotent Stem Cell Line from a Patient with Phenylketonuria
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Yu I, Park H, Lee J, Jeong J
- KMID: 2574566
- Int J Stem Cells.
- 2025 Nov;18(4):426-436.
- doi: 10.15283/ijsc25073
Phenylketonuria (PKU), an autosomal recessive genetic disorder, has been documented to exhibit over 950 distinct mutations. This condition primarily affects the metabolism of phenylalanine, which is affected by a deficiency... -
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- Kap1 Regulates Protein Stability of Nanog by Interfering with Fbxw8-Dependent Ubiquitination
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Moon HJ, Lee N, Lee BS, Park MS, Jung YJ, Kim YS, Kim JH
- KMID: 2574564
- Int J Stem Cells.
- 2025 Nov;18(4):401-411.
- doi: 10.15283/ijsc25023
Nanog is a key transcription factor that regulates the self-renewal and pluripotency of embryonic stem cells (ESCs). Although Kap1 has been demonstrated to regulate the stability of stemness factors, including Oct4... -
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- Recent Applications of Lung Organoid and Lung-on-a-Chip Technologies for Evaluating the Toxicity of Fine Particulate Matter
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Kang M, Kim JY, Kwon CW, Kim WJ, Hong SH
- KMID: 2574561
- Int J Stem Cells.
- 2025 Nov;18(4):357-367.
- doi: 10.15283/ijsc25036
There is mounting epidemiologic and experimental evidence of the harmful effects of exposure to fine particulate matter (PM2.5) on human lung health. However, the current utilization of in vitro two-dimensional... -
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- Unraveling Optimal Dose and Responsive Markers for Human Cord Blood Derived Mononuclear Cells in Alleviating Bronchopulmonary Dysplasia in Neonatal Mice
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Chen J, Chen Y, Du X, He L, Wang Y, Han H, Li Q, Zhou H, Feng Z
- KMID: 2574562
- Int J Stem Cells.
- 2025 Nov;18(4):368-383.
- doi: 10.15283/ijsc25008
Bronchopulmonary dysplasia (BPD), characterized by impaired alveolarization and dysregulated vascularization, is a severe health burden for neonates worldwide. Hyperoxia induced acute lung injury is a major contributor to the progression... -
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- Advances in Cell and Gene Therapy for Rare Disease Treatment
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Baek HJ, Nam Y, Rim YA, Ju JH
- KMID: 2574559
- Int J Stem Cells.
- 2025 Nov;18(4):324-337.
- doi: 10.15283/ijsc25028
A rare disease is generally defined as a medical condition that affects a small proportion of the population, though specific thresholds vary across countries. Despite regional differences, these definitions consistently... -
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