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Mechanism Underlying Shikonin-induced Apoptosis and Cell Cycle Arrest on SCC25 Human Tongue Squamous Cell Carcinoma Cell Line

Oh SH, Park SJ, Yu SB, Kim YH, Kim IR, Park BS

  • Int J Oral Biol.
  • 2015 Mar;40(1):51-61.
  • doi: 10.11620/IJOB.2015.40.1.051
Shikonin, a major ingredient in the traditional Chinese herb Lithospermumerythrorhizon, exhibits multiple biological functions including antimicrobial, anti-inflammatory, and antitumor effects. It has recently been reported that shikonin displays antitumor properties...
Identification of the Bacteria Isolated from Oral Cavities in Korea

Choi MH, Park SN, Kook JK

  • Int J Oral Biol.
  • 2015 Mar;40(1):41-50.
  • doi: 10.11620/IJOB.2015.40.1.041
The aim of this study was to identify bacteria isolated from the oral cavities and to determine their antimicrobial susceptibility against eight antibiotics. The bacterial strains were obtained from the...
Effects of Sub Minimal Inhibitory Concentration of Metronidazole and Penicillin on Morphology of Aggregatibacter actinomycetemcomitans: Scanning Electron Microscopy Observation

Kwon YW, Lee SY

  • Int J Oral Biol.
  • 2015 Mar;40(1):35-39.
  • doi: 10.11620/IJOB.2015.40.1.035
Minimal inhibitory concentration (MIC) is the lowest concentration of antibiotics that inhibits the visible growth of bacteria. It has been reported that sub-MIC of antibiotics may result in morphological alterations,...
Staurosporine Induces ROS-Mediated Process Formation in Human Gingival Fibroblasts and Rat Cortical Astrocytes

Lee HG, Kim DS, Moon SA, Kang JW, Seo JT

  • Int J Oral Biol.
  • 2015 Mar;40(1):27-33.
  • doi: 10.11620/IJOB.2015.40.1.027
In the present study, we investigated the effect of staurosporine on the formation of cellular processes in human gingival fibroblasts and rat astrocytes. Staurosporine caused a rapid induction of process...
Hypoxia Inducible Factor-1alpha Directly Induces the Expression of Receptor Activator of Nuclear Factor-kappaB Ligand in MLO-Y4 Osteocytes

Baek K, Park HJ, Baek JH

  • Int J Oral Biol.
  • 2015 Mar;40(1):19-25.
  • doi: 10.11620/IJOB.2015.40.1.019
Osteocytes may function as mechanotransducers by regulating local osteoclastogenesis. Reduced availability of oxygen, i.e. hypoxia, could occur during disuse, bone development, and fracture. Receptor activator of nuclear factor-kappaB ligand (RANKL)...
House Dust Mite Extract Induces PLC/IP3-dependent Ca2+ Signaling and IL-8 Expression in Human Gingival Epithelial Cells

Son GY, Son A, Park W, Shin DM

  • Int J Oral Biol.
  • 2015 Mar;40(1):11-17.
  • doi: 10.11620/IJOB.2015.40.1.011
The gingival epithelium of the oral cavity is constantly exposed to exogenous stimuli such as bacterial toxins, allergens, and thermal changes. These exogenous stimuli are resisted by innate host defense...
Osteocalcin Expression and Mineralization in Developing Tooth of Xenopus laevis

Park JH, Kwon KT, Park BK, Lee YH

  • Int J Oral Biol.
  • 2015 Mar;40(1):1-9.
  • doi: 10.11620/IJOB.2015.40.1.001
Osteocalcin (OC) is the most abundant noncollagenous protein of extracellular matrix in the bone. In an OC deficient mouse, bone formation rates are increased in cancellous and cortical bones. OC...

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