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Insulin autoimmune syndrome associated with alpha-lipoic acid in a young woman with no concomitant disease

Lee SB, Lee MY, You JH, Kim SH, Nam JS

Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia, extremely high serum insulin levels, and high titers of autoantibodies against endogenous insulin, in the absence of exogenous insulin injection. IAS...
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Allergic reaction to recombinant human insulin

Choi SJ, Kwon MK, Park M, Bae SY, Oh HH, Lee JH, Moon JI, Park CS, Won JC, Ko KS, Rhee BD, Kim JM

Insulin-induced allergy is a rare adverse drug reaction since the introduction of recombinant human insulin. However, recombinant insulin-induced allergy is still being reported in 0.1% to 2% of all patients...
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Clinical Features and Causes of Endogenous Hyperinsulinemic Hypoglycemia in Korea

Woo CY, Jeong JY, Jang JE, Leem J, Jung CH, Koh EH, Lee WJ, Kim MS, Park JY, Lee JB, Lee KU

BACKGROUND: Endogenous hyperinsulinemic hypoglycemia (EHH) is characterized by an inappropriately high plasma insulin level, despite a low plasma glucose level. Most of the EHH cases are caused by insulinoma, whereas...
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Insulin autoimmune syndrome induced by methimazole in a Korean girl with Graves' disease

Lee SH, Oh SH, Chung WY

Hypoglycemia was detected in a 15-year-old girl due to loss of consciousness. She was diagnosed with Graves' disease and was being treated with methimazole for the past 4 months. A...
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Recurrent Insulin Autoimmune Syndrome Caused by alpha-Lipoic Acid in Type 2 Diabetes

Bae SM, Bae MN, Kim EY, Kim IK, Seo MW, Shin JK, Cho SR, Jeong GH

Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia caused by insulin autoantibodies in the absence of exogenous insulin administration. Some drugs containing sulfhydryl compounds are known to initiate the...
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Unusually Elevated Serum Insulin Level in a Diabetic Patient during Recombinant Insulin Therapy

Kim S, Yun YM, Hur M, Moon HW

Herein, we report a case of unusually elevated serum insulin level as a result of increased anti-insulin antibody (IA)-bound insulin after continuous subcutaneous insulin infusion therapy. Detecting free insulin (unbound...
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The Effects of Anti-insulin Antibodies and Cross-reactivity with Human Recombinant Insulin Analogues in the E170 Insulin Immunometric Assay

Kim S, Yun YM, Hur M, Moon HW, Kim JQ

BACKGROUND: Insulin assays are affected by varying degrees of interference from anti-insulin antibodies (IAs) and by cross-reactivity with recombinant insulin analogues. We evaluated the usefulness of the E170 insulin assay...
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Spontaneous Hypoglycemia due to Insulin Antibody after Insulin Treatment of Diabetic Ketoacidosis

Chung JO, Cho DH, Chung DJ, Chung MY

Hypoglycemia in diabetic patients is usually caused by excessive exogenous insulin or the administration of an insulin secretagogue relative to the prevailing glucose concentration. Thus, the clinical manifestations of hypoglycemia...
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A Case of Change of Insulin-Specific Antibodies following Desensitization in Insulin Hypersensitivity Patients

  • KMID: 2146040
  • Korean J Asthma Allergy Clin Immunol.
  • 2010 Mar;30(1):63-67.
Although human insulin is widely used, insulin allergy is still an important issue. Desensitization is one of the strategies to overcome insulin allergy, but there are few report concerning the...
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A case of autoimmune insulin syndrome

Kim DJ, Kim NH, Seo JA, Kim SG, Choi KM, Baik SH, Choi DS

  • KMID: 2256511
  • Korean J Med.
  • 2006 Dec;71(6):683-687.
Autoimmune insulin syndrome is characterized by a combination of fasting hypoglycemia, high total serum insulin concentrations, and the presence of autoantibodies to the native human insulin in serum. A healthy...
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Effect of insulin on VEGF synthesis of peritoneal mesothelial cells: possible implications of intraperitoneal insulin on the long-term peritoneal function

Kang DH

  • KMID: 2305952
  • Korean J Med.
  • 2006 Nov;71(5):518-526.
BACKGROUND: Intraperitoneal (IP) insulin administration in peritoneal dialysis (PD) patients has several advantages, including the prevention of major fluctuations of blood glucose and hyperinsulinemia and the formation of insulin antibodies....
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A Case of Autoimmune Hypoglycemia Complicated with Diabetic Ketoacidosis

Shim MS, Kim MY, Kim MJ, Lee Y, Lee BJ, Chung CH, Shin YG

Autoimmune hypoglycemia is characterized by hyperinsulinemia, fasting hypoglycemia, and the presence of insulin auto- antibodies without previous exposure to exogenous insulin. We experienced a case of autoimmune hypoglycemia without diabetes...
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Selective beta-Cell Loss and alpha-Cell Expansion in Islets of Type 2 Diabetic Patients

Cho JH, Lee IK, Yoon KH, Ko SH, Suh SH, Lee JM, Kim SR, Ahn YB, Lee JM, Son HS, Kang MI, Cha BY, Lee KW, Son HY, Kang SK

  • KMID: 2331744
  • J Korean Diabetes Assoc.
  • 2001 Apr;25(2):164-177.
BACKGROUND: It has been reported that a decrease in the beta-cell mass, may play a major role in the development of type 2 diabetes. Some stimuli that cause beta-cell loss...
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Two Cases of hypoglycemia in IDDM patients with insulin antibody

Kim GA, Lee KW, Kim MR, Kim YJ, Jang JN, Bae SK, Son BG

  • KMID: 2461628
  • J Korean Soc Endocrinol.
  • 1996 Jun;11(2):240-246.
Hirata et al. first described the association of insulin antibodies with hypoglycemia attacks and decreased glucose tolerance in a patient who had not previously received insulin injections. Since that time...
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