- Lipoxygenase Inhibitory Activity of Korean Indigenous Mushroom Extracts and Isolation of an Active Compound from Phellinus baumii
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Lee SW, Song JG, Hwang BS, Kim DW, Lee YJ, Woo EE, Kim JY, Lee IK, Yun BS
- KMID: 2312743
- Mycobiology.
- 2014 Jun;42(2):185-188.
We investigated a total of 335 samples of Korean native mushroom extracts as part of our lipoxygenase (LOX) inhibitor screening program. Among the mushroom-methanolic extracts we investigated, 35 exhibited an... -
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- Vasorelaxant mechanisms of ketamine in rabbit renal artery
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Jung I, Jung SH
- KMID: 2236255
- Korean J Anesthesiol.
- 2012 Dec;63(6):533-539.
- doi: 10.4097/kjae.2012.63.6.533
BACKGROUND: Ketamine is a non-barbiturate anesthetic agent which has various effects on the cardiovascular system. Among them, ketamine is known for its hypotensive properties. The hypotension is thought to be... -
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- Antihypertensive Angiotensin I-Converting Enzyme Inhibitory Activity and Antioxidant Activity of Vitis hybrid-Vitis coignetiae Red Wine Made with Saccharomyces cerevisiae
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Jang JH, Lee JS
- KMID: 2312631
- Mycobiology.
- 2011 Jun;39(2):137-139.
A Vitis hybrid-Vitis coignetiae red wine was vinified by fermentation of a mixture of a Vitis hybrid-Vitis coignetiae must with Saccharomyces cerevisiae KCTC 7904 at 25degrees C for 10 days.... -
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- Production of the Acetylcholinesterase Inhibitor from Yarrowia lipolytica S-3
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Lee DH, Lee JS, Yi SH, Lee JS
- KMID: 2411404
- Mycobiology.
- 2008 Jun;36(2):102-105.
The acetylcholinesterase (AChE) inhibitor of Yarrowia lipolytica S-3 was maximally produced when it was incubated at 30degrees C for 36 h in an optimal medium containing 1% yeast extract, 2%... -
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- Direct Block of Cloned K+ Channels, Kv1.5 and Kv1.3, by Cyclosporin A, Independent of Calcineurin Inhibition
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Choi BH, Hahn SJ
- KMID: 2071619
- Korean J Physiol Pharmacol.
- 2005 Dec;9(6):353-361.
The interaction of cyclosporine A (CsA), an immunosuppressant, with rat brain Kv1.5 (Kv1.5) channels, which were stably expressed in Chinese hamster ovary cells, was investigated using the whole-cell patch-clamp technique.... -
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- Epi-Leptosphaerin: A New L-Isoascorbic Acid Derivative from Marine Sponges
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Kulkarni R, Jo AR, Kim YH, Na M
- KMID: 2312913
- Nat Prod Sci.
- 2015 Dec;21(4):293-296.
- doi: 10.20307/nps.2015.21.4.293
A new L-isoascorbic acid derivative epi-leptosphaerin (1) and two known compounds leptosphaerin (2), and verongamine (3) were isolated from sponges of the orders Verongida and Thorectidae. Compounds 1 and 2... -
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- Inhibitory Effects of Potassium Channel Blockers on Carbachol-induced Contraction in Rat Detrusor Muscle
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Oh SJ, Ahn SC
- KMID: 1130042
- J Korean Med Sci.
- 2003 Oct;18(5):701-706.
- doi: 10.3346/jkms.2003.18.5.701
We present accidental findings that potassium channel blockers, such as tetraethyl-ammonium (TEA) or 4-aminopyridine (4-AP), inhibit the sustained tonic contraction induced by carbachol in rat detrusor muscle strips. The relatively... -
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- Studies on anticancer effects of extracts caesalpinia sappan on oral carcinoma and osteosarcoma cells
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Lee JS, Kim YG, Kim JH
- KMID: 2328350
- J Korean Assoc Oral Maxillofac Surg.
- 2001 Aug;27(4):281-288.
Anticancer effect of methanol extract of Caesalpinia sappan L. on oral carcinoma (KB) and osteosarcoma (HOS) cells were investigated in this study. In order to elucidate the anticancer mechanism of... -
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- Tamoxifen Induces Apoptosis of Leishmania major Promastigotes in Vitro
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Doroodgar , Delavari M, Doroodgar , Abbasi A, Taherian A, Doroodgar
- KMID: 2374011
- Korean J Parasitol.
- 2016 Feb;54(1):9-14.
- doi: 10.3347/kjp.2016.54.1.9
Tamoxifen is an antagonist of the estrogen receptor and currently used for the treatment of breast cancer. The current treatment of cutaneous leishmaniasis with pentavalent antimony compounds is not satisfactory.... -
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- Production and Characterization of a New alpha-Glucosidase Inhibitory Peptide from Aspergillus oryzae N159-1
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Kang MG, Yi SH, Lee JS
- KMID: 1964229
- Mycobiology.
- 2013 Sep;41(3):149-154.
- doi: 10.5941/MYCO.2013.41.3.149
An alpha-glucosidase inhibitor was developed from Aspergillus oryzae N159-1, which was screened from traditional fermented Korean foods. The intracellular concentration of the inhibitor reached its highest level when the fungus... -
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- Effect of Genistein, a Tyrosine Kinase Inhibitor, on the Cloned Rat Brain Potassium Channel Kv1.5
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Choi BH
- KMID: 2071632
- Korean J Physiol Pharmacol.
- 2006 Oct;10(5):243-249.
The effect of genistein, widely used as a specific tyrosine kinase inhibitor, on rat brain Kv1.5 channels which were stably expressed in Chinese hamster ovary cells was investigated using the... -
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- Effects of Opioids on the Contractility of Isolated Human Pregnant Uterine Muscle
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Yoo KY, Kim HS, Kwak SH, Jeong CY, Im WM
- KMID: 2091565
- Korean J Anesthesiol.
- 2000 Dec;39(6):775-779.
- doi: 10.4097/kjae.2000.39.6.775
BACKGROUND: Effects of fentanyl, sufentanil, meperidine, and morphine on the spontaneous contractility of isolated human pregnant uterine muscle strips were determined. METHODS: Uterine specimens were obtained from normal full-term parturients... -
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- Pancreatic lipase inhibitory activity of taraxacum officinale in vitro and in vivo
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Zhang J, Kang MJ, Kim MJ, Kim ME, Song JH, Lee YM, Kim JI
- KMID: 2139192
- Nutr Res Pract.
- 2008 Dec;2(4):200-203.
- doi: 10.4162/nrp.2008.2.4.200
Obesity has become a worldwide health problem. Orlistat, an inhibitor of pancreatic lipase, is currently approved as an anti-obesity drug. However, gastrointestinal side effects caused by Orlistat may limit its... -
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- In Vitro Activity of Tigecycline Against Orientia tsutsugamushi
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Lee SM, Kwon HY, Im JH, Baek JH, Hwang SS, Kang JS, Chung MH, Lee JS
- KMID: 2374140
- Yonsei Med J.
- 2016 Jul;57(4):1034-1037.
- doi: 10.3349/ymj.2016.57.4.1034
Scrub typhus is a zoonosis caused by Orientia tsutsugamushi (O. tsutsugamushi) occurring mainly in autumn in Korea. The need of new antibiotics has arisen with a report on strains resistant... -
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- Biological Activities and Stability of a Standardized Pentacyclic Triterpene Enriched Centella asiatica Extract
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Puttarak P, Brantner A, Panichayupakaranant P
- KMID: 2312916
- Nat Prod Sci.
- 2016 Mar;22(1):20-24.
- doi: 10.20307/nps.2016.22.1.20
Pentacyclic triterpenes, mainly, asiatic acid, madecassic acid, asiaticoside, and madecassoside are the active constituents of Centella asiatica. A pentacyclic triterpene enriched C. asiatica extract (PRE) was prepared and standardized to... -
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- Inhibitory activity of Euonymus alatus against alpha-glucosidase in vitro and in vivo
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Lee SK, Hwang JY, Song JH, Jo JR, Kim MJ, Kim ME, Kim JI
- KMID: 2313312
- Nutr Res Pract.
- 2007 Sep;1(3):184-188.
The major goal in the treatment of diabetes mellitus is to achieve near-normal glycemic control. To optimize both fasting blood glucose and postprandial glucose levels is important in keeping blood... -
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- Effect of phlorotannins isolated from Ecklonia cava on angiotensin I-converting enzyme (ACE) inhibitory activity
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Wijesinghe WAJP, Ko SC, Jeon YJ
- KMID: 2313504
- Nutr Res Pract.
- 2011 Apr;5(2):93-100.
Inhibition of angiotensin I-converting enzyme (ACE) activity is the most common mechanism underlying the lowering of blood pressure. In the present study, five organic extracts of a marine brown seaweed... -
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- In vitro toxicity of melamine against Tetrahymena pyriformis cells
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Wang Z, Chen L, Al-Kasir R, Han B
- KMID: 1067334
- J Vet Sci.
- 2011 Mar;12(1):27-34.
- doi: 10.4142/jvs.2011.12.1.27
This study assessed the toxicity of melamine against the unicellular eukaryotic system of Tetrahymena (T.) pyriformis exposed to 0, 0.05, 0.25, 0.5, 2.5, and 5 mg/mL of melamine. Cell growth... -
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- Characterization of an Anti-gout Xanthine Oxidase Inhibitor from Pleurotus ostreatus
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Jang IT, Hyun SH, Shin JW, Lee YH, Ji JH, Lee JS
- KMID: 2312763
- Mycobiology.
- 2014 Sep;42(3):296-300.
- doi: 10.5941/MYCO.2014.42.3.296
We selected Pleurotus ostreatus from among several edible mushrooms because it has high anti-gout xanthine oxidase (XOD) inhibitory activity. The maximal amount of XOD inhibitor was extracted when the Pleurotus... -
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- Effects of Cl- channel blockers on the cardiac ATP-sensitive K+ channel
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Kwak YG
- KMID: 2285224
- Korean J Physiol Pharmacol.
- 1999 Jun;3(3):305-313.
To explore whether Cl- channel blockers interact with the ATP-sensitive K+ (KATP) channel, I have examined the effect of two common Cl- channel blockers on the KATP channel activity in isolated rat... -
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