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microRNAs in Mycobacterial Infection: Modulation of Host Immune Response and Apoptotic Pathways

Agarwal RG, Sharma P, Nyati KK

Our current knowledge of mycobacterial infections in humans has progressively increased over the past few decades. The infection of Mycobacterium tuberculosis causes tuberculosis (TB) disease, which has reasoned for excessive...
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The Interplay between Host Immunity and Respiratory Viral Infection in Asthma Exacerbation

Hossain FM, Choi JY, Uyangaa E, Park SO, Eo SK

Asthma is one of the most common and chronic diseases characterized by multidimensional immune responses along with poor prognosis and severity. The heterogeneous nature of asthma may be attributed to...
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Curcumin Elevates T(FH) Cells and Germinal Center B Cell Response for Antibody Production in Mice

Kim DH, Lee HG, Choi JM

Curcumin is a natural product extracted from Curcuma longa. It has been reported as a potent antioxidant and anti-inflammatory compound. Previous studies have demonstrated that curcumin suppresses pro-inflammatory cytokine production...
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Ubiquitin E3 Ligase Pellino-1 Inhibits IL-10-mediated M2c Polarization of Macrophages, Thereby Suppressing Tumor Growth

Kim D, Koh J, Ko JS, Kim HY, Lee H, Chung DH

Pellino-1 is a ubiquitin (Ub) E3 ligase that plays a role in M1, but not M2a polarization of macrophages. However, it is unknown whether Pellino-1 regulates IL-10-mediated M2c polarization of...
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Neutrophilic Granule Protein Is a Novel Murine LPS Antagonist

Hong J, Qu P, Wuest TR, Huang H, Huang C, Lin PC

Neutrophilic granule protein (NGP) was previously reported as a granular protein of neutrophils in mouse, but the function has not been known clearly. We found the presence of the possible...
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Mesenchymal Stem Cells Ameliorate Renal Inflammation in Adriamycin-induced Nephropathy

Kim HS, Lee JS, Lee HK, Park EJ, Jeon HW, Kang YJ, Lee TY, Kim KS, Bae SC, Park JH, Han SB

Mesenchymal stem cells (MSCs) ameliorate the renal injury in Adriamycin (ADR)-induced nephropathy, but the mechanisms underlying their efficacy remain incompletely understood. In this study, we demonstrated that MSCs increased the...
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Viperin Differentially Induces Interferon-Stimulated Genes in Distinct Cell Types

Kim JJ, Kim KS, Eom J, Lee JB, Seo JY

Viperin is an IFN-stimulated gene (ISG)-encoded protein that was identified in human primary macrophages treated with IFN-γ and in human primary fibroblasts infected with cytomegalovirus (CMV). This protein plays multiple...
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