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Regulatory T Cells in B Cell Follicles

Chang JH, Chung Y

Understanding germinal center reactions is crucial not only for the design of effective vaccines against infectious agents and malignant cells but also for the development of therapeutic intervention for the...
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Immunomodulatory Effects of ZYM-201 on LPS-stimulated B Cells

Lee YE, Kim S, Jung WJ, Lee HS, Kim MY

ZYM-201 is a methyl ester of triterpenoid glycoside from Sanguisorba officinalis which has been used for treatment of inflammatory and metabolic diseases. In this study, immunomodulatory effects of ZYM-201 on...
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Contrasting Roles of Different Endoglin Forms in Atherosclerosis

Jang YS, Choi IH

Endoglin (also known as CD105 or TGF-beta type III receptor) is a co-receptor involved in TGF-beta signaling. In atherosclerosis, TGF-beta signaling is crucial in regulating disease progression owing to its...
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5-aminoimidazole-4-carboxamide Riboside Induces Apoptosis Through AMP-activated Protein Kinase-independent and NADPH Oxidase-dependent Pathways

Wi SM, Lee KY

It is debatable whether AMP-activated protein kinase (AMPK) activation is involved in anti-apoptotic or pro-apoptotic signaling. AICAR treatment increases AMPK-alpha1 phosphorylation, decreases intracellular reactive oxygen species (ROS) levels, and significantly...
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Effects of Endurance Training on the Serum Levels of Tumour Necrosis Factor-alpha and Interferon-gamma in Sedentary Men

Jahromi AS, Zar A, Ahmadi F, Krustrup P, Ebrahim K, Hovanloo F, Amani D

Physical activity could be considered one of the factors that affect the immune system status and function. To find the relation between exercise and cytokines, we examined the possible effects...
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TRIF Deficiency does not Affect Severity of Ovalbumin-induced Airway Inflammation in Mice

Kim TH, Kim DJ, Park JH, Park JH

Allergic asthma is a chronic pulmonary inflammatory disease characterized by reversible airway obstruction, hyperresponsiveness and eosinophils infiltration. Toll-like receptors (TLRs) signaling are closely associated with asthma and have emerged as...
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