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Efficient Induction of Th1-type Immune Responses to Hepatitis B Virus Antigens by DNA Prime-Adenovirus Boost

Lee CG, Yang SH, Park SH, Song MK, Choi SY, Sung YC

BACKGROUND: Chronic infection with hepatitis B virus (HBV) affects about 350 million people worldwide, which have a high risk of development of cirrhosis and hepatocellular carcinoma. Treatment of chronic HBV...
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Human Activated Lymphocyte Treated with Anti-CD3, CD16, CD56 Monoclonal Antibody and IL-2

Hong SM, Lee DW, Kang JG, Kim HS, Cho SH

BACKGROUND: Throughtout the last three decades, the therapy of leukemias and lymphoma has set the stage for curative cancer therapy in systemic malignant disease. This was the result of an...
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Immunocell Therapy for Lung Cancer: Dendritic Cell Based Adjuvant Therapy in Mouse Lung Cancer Model

Lee SJ, Kim MJ, In SH, Baek S, Lee H

BACKGROUND: The anti-tumor therapeutic effect of autologous tumor cell lysate pulsed-dendritic cells (DCs) was studied for non-immunogenic and immune suppressive lung cancer model. To test the possibility as an adjuvant...
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p38 Mitogen-Activated Protein Kinase and Extracellular Signal-Regulated Kinase Regulate Nitric Oxide Production and Inflammatory Cytokine Expression in Raw Cells

Choi CH, Kim SH

BACKGROUND: p38 and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase (MAPK) signaling are thought to have critical role in lipopolysaccharide (LPS)-induced immune response but the molecular mechanism underlying the induction...
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IL-18Ralpha Mediated GATA-3 Induction by Th2 Cells: IL-12 Supports IL-18Ralpha Expression in Th2 Cells

Joo IS, Sun MJ, Kim DY, Lee SJ, Ha YM, Cho JJ, Park CS, Ahn HJ

BACKGROUND: IL-18 was originally cloned as a IFN-gamma inducing factor in primed T cells. In synergy with IL-12, IL-18 has been shown to induce strikingly high levels of IFN-gamma production...
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Inhibition of iNOS Expression Via Ursodeoxycholic Acid in Murine Microglial Cell, BV-2 Cell Line

Joo SS, Won TJ, Hwang KW, Lee DI

BACKGROUND: Inflammation in the brain has known to be associated with the development of a various neurological diseases. The hallmark of neuro-inflammation is the activation of microglia, brain macrophage. Pro-inflammatory...
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Interleukin-7 Receptor is Indispensable for Proliferation and Survival in Thymic gamma sigma T Cell Development

Kim DH, Yoon BH, Jung JE, Kim HS, Ko SH, Choi EY, Lee KH, Kim K, Ye SK, Chung MH

BACKGROUND: Interleukin-7 receptor (IL-7R) alpha-deficient mice have small numbers of B cells and alpha beta T cells in periphery, they totally lack gamma sigma T cells. In addition, the V-J...
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