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Expression of Intracellular Single Chain Antibody Specific to Hepatitis B Virus X Protein

Jin YH, Kim HI, Park S

BACKGROUND: Intracellular antibody specific to hepatitis B virus X protein (HBx) might be useful for studying the role of HBx in hepatocellular carcinogenesis and HBV replication. METHODS: With variable region...
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CD30-Mediated Regulation of Cell Adhesion Molecule Expression on Murine T Cells

Nam SY

BACKGROUND: CD30 is a member of TNF receptor family and expressed on lymphocytes and other hematopoietic cells following activation as well as Hodgkin and Reed- Sternberg cells in Hodgkin's lymphoma....
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Characterization of the Monoclonal Antibody Specific to Human S100A2 Protein

Kim JW, Yoon SY, Kim JH, Joo JH, Kim JS, Lee Y, Yeom YI, Choe YK, Choe IS

BACKGROUND: The S100A2 gene, also known as S100L or CaN19, encodes a protein comprised of 99-amino acids, is a member of the calcium-binding proteins of EF-hand family. According to a...
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Regulation of RANTES and MCP Expression in Human Nasal Mucosal Fibroblasts

Ha YC, Cho JJ, Yoo YC, Yang WY

BACKGROUND: Fibroblast functions both as a structural element and as a vital immunoregulatory cell. Fibroblasts regulate inflammation through governing of chemokine expression. In order to elucidate the mechanisms by which...
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CCR7 Ligands Induced Expansion of Memory CD4+ T Cells and Protection from Viral Infection

Eo SK, Cho JG

BACKGROUND: CC chemokine receptor (CCR) 7 and cognate CCR7 ligands, CCL21 (formerly secondary lymphoid tissue chemokine [SLC]) and CCL19 (formerly Epstein-Barr virus-induced molecule 1 ligand chemokine [ELC]), were known to...
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Production of IFN-gamma by TNF-alpha in Macrophages from Tumor Micro Environment; Significance in Angiogenic Switch Control

Pyo SN, Baek S, Kwak JD, Park DS, Joe SJ, Lee HA

BACKGROUND: The role of macrophages in tumor angiogenesis is known to be the production of angiogenic cytokines and growth factors including TNF-alpha. Recently, macrophage also can produce the INF-gamma that...
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Effect of Cyclooxygenase-2 Specific Inhibitor (SC-58635) on the Production of Nitric Oxide and Prostaglandin E2 in Lipopolysaccharide-stimulated Macrophage Cells

Hong SJ, Yang HI, Yoon HJ, Lee MS, Kang HJ, Kim WU, Lee SH, Cho CS, Kim HY

BACKGROUND: Celecoxib, a COX-2 specific inhibitor, has recently been used for the treatment of rheumatoid arthritis. However, the molecular and cellular mechanisms of celecoxib against RA inflammation remain to be...
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In Vitro Effect of Interleukin-11 (IL-11) on Megakaryopoiesis from Umbilical Cord Blood Cells

Lee KK, Kim CK, Lee NS, Kim SJ, Cheong HJ, Lee KT, Park SK, Baick SH, Won JH, Hong DS, Park HS

BACKGROUND: The megakaryopoiesis and platelet production is regulated by several hematopoietc factors such as thrombopoietin (TPO), interleukin-11 (IL-11) and interleukin-3 (IL-3). IL-11 is a potent stimulator of megakaryopoiesis in vivo,...
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Role of Immune Response to Type II Collagen in the Pathogenesis of Rheumatoid Arthritis

Jung YO, Hong SJ, Kim HY

Type II collagen (CII), major component of hyaline cartilage, has been considered as an auto-antigen in rheumatoid arthritis (RA). However, the clinical and biological significances with regard to the CII...
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Role of Nuclear Factor (NF)-kappaB Activation in Tumor Growth and Metastasis

Ko HM, Choi JH, Ra MS, Im SY

BACKGROUND: Platelet-activating factor (PAF) induces nuclear factor (NF)-kappaB activation and angiogenesis and increases tumor growth and pulmonary tumor metastasis in vivo. The role of NF-kappaB activation in PAF-induced angiogenesis in...
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