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T cell costimulation by CD28, CTLA-4, and ICOS

Lee KM

T cells play a central role in the initiation and regulation of the immune response to foreign antigens. Full activation of T cells requires the engagement of T cell receptor complex...
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The effect of Korean mistletoe extract M11C (non-lectin components) on IL-1beta release and expression from macrophages

Chang SH, Jun MH, Kang TB, Mun SH, Lee JH, Seong NS, Lee ST, Kim JB, Her E

BACKGROUND: Korean mistletoe (Viscum album) extract has been found to posses immunostimulatory activity. In this study, Korean mistletoe extract, M11C (non-lectin components), was used to know whether this extract might...
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Interferon consensus sequence binding protein: Not essential for interferon alpha-mediated antiviral response to vesicular-stomatitis virus infection in HL-60 cells

Park BK

BACKGROUND: The role of the interferon consensus sequence binding protein (ICSBP), a member of interferon regulatory factor family, in protecting against a vesicular stomatitis virus (VSV) infection has not been...
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Characteristics of B Cell proliferation by polysaccharide fraction of Paeonia japonica miyabe

Park HR, Ham YH, Yee ST, Paik SG, Jo SK

BACKGROUND: Paeonia j ap onica Miyabe is a medicinal plant which has been widely used as a component of blood-building decoctions (Chinese medicinal concept : Bu-Xie). The immunopharmacological characteristics of...
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Association of HIV infection with MICA (MHC class I chain-related A) gene alleles

Kang MW, Wie SH, Kim YR, Lee JS, Pyo CW, Han H, Kim TG

BACKGROUND: A large number of diseases occur in association with specific HLA-B or-C alleles. Recently a new gene, termed maj or histocompatibility complex class I chain-related gene A (MICA), has...
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Nitric oxide-induced immune switching in experimental inflammatory autoimmune diseases

Kwak HJ, Kim HJ, Park JS, Jun CD, Lee MY, Shin TK, Chung HT

BACKGROUND: Nitric oxide (NO) production has been described as a double-edged sword eliciting both pro-and anti-inflammatory effect s in different immune reactions. This work was undertaken to investigate the immunoregulatory...
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Effect of target cell nitric oxide synthesis on the sensitivity to lymphokine-activated killer cell cytotoxicity

Park SI, Park JH, Lee CK, Kim SC, Choi BG, Kwak JY, Yim CY

BACKGROUND: Nitric oxide (NO), a cytotoxic molecule is produced in various tissues including tumor cells during interleukin-2 (IL-2) therapy . Lymphokine-activated killer (LAK) cells are induced during IL-2 therapy, and...
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Study on the expression and detection of the p53 mutation in Korean colon cancer cell lines

Jung JY, Oh SJ

BACKGROUND: Inactivation in p53 tumor suppressor gene through a point mutation and deletion is one of the most frequent genetic changes found in human cancer, with 50% of an incidence....
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Mechanism of aging and prevention

Kim JS

Aging is a senescence and defined as a normal physiologic and structural alterations in almost all organ systems with age. As Leonard Hayflick, one of the first gerontologist s to...
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Study of plasma transforming growth factor-beta 1 level as a useful tumor marker in various cancers

Shin H, Lim CK, Choi IY, Lee DY, Noh DY, Ryu MH, Lee HS, Bang YJ, Park JS, Jin SW

BACKGROUND: Many investigators have found transforming growth factor-1 (TGF-1) to be elevated in tumors. Changes in responsiveness to TGF-1 have been linked to malignant transformation, tumor progression and tumor regression....
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