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Potential Implications of Long Noncoding RNAs in Autoimmune Diseases

Hur K, Kim SH, Kim JM

Long noncoding RNAs (lncRNAs) are non-protein coding RNAs of more than 200 nucleotides in length. Despite the term “noncoding”, lncRNAs have been reported to be involved in gene expression. Accumulating...
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The Role of Plasmacytoid Dendritic Cells in Gut Health

Won HY, Lee JY, Ryu D, Kim HT, Chang SY

Plasmacytoid dendritic cells (pDCs) are a unique subset of cells with different functional characteristics compared to classical dendritic cells. The pDCs are critical for the production of type I IFN...
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Age-related Autoimmune Changes in Lacrimal Glands

de Souza R, de Paiva C, Alves MR

Aging is a complex process associated with dysregulation of the immune system and low levels of inflammation, often associated with the onset of many pathologies. The lacrimal gland (LG) plays...
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Osteoclasts in the Inflammatory Arthritis: Implications for Pathologic Osteolysis

Jung YK, Kang YM, Han S

The enhanced differentiation and activation of osteoclasts (OCs) in the inflammatory arthritis such as rheumatoid arthritis (RA) and gout causes not only local bone erosion, but also systemic osteoporosis, leading...
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CD72 is a Negative Regulator of B Cell Responses to Nuclear Lupus Self-antigens and Development of Systemic Lupus Erythematosus

Tsubata T

Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease characterized by production of autoantibodies to various nuclear antigens and overexpression of genes regulated by IFN-I called IFN signature. Genetic...
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The Role of Autophagy in Eosinophilic Airway Inflammation

Lee J, Kim HS

Autophagy is a homeostatic mechanism that discards not only invading pathogens but also damaged organelles and denatured proteins via lysosomal degradation. Increasing evidence suggests a role for autophagy in inflammatory...
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Aged Sanroque Mice Spontaneously Develop Sjögren's Syndrome-like Disease

Choi SS, Jang E, Oh YK, Jang K, Cho ML, Park SH, Youn J

Sjögren's syndrome (SS) is a chronic inflammatory autoimmune disorder that affects mainly salivary and lacrimal glands, but its cause remains largely unknown. Clinical data indicating that SS occurs in a...
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